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Biomedical subjects

L Laasonen

Publications and source records attributed to L Laasonen.

At least 55 records · Page 3Linked to original sources
PubMed1984

Steroid treatment and aseptic necrosis of the femoral head in renal transplant recipients.

The subject of our study was 546 renal transplant recipients with a graft survival for minimum 12 months. Of these, 29 renal recipients (5.3%) developed aseptic necrosis of the femoral head. The examination revealed that there were no significant differences between the renal recipients with hip necrosis and the control group in the total quantities of administered glucocorticosteroids, whereas there was a highly significant correlation between the two groups in the number of the intravenously administered methylprednisolone pulse doses.

Azathioprine↗
PubMed1983

Angioleiomyoma of the common bile duct.

An 80-year-old woman with angioleiomyoma in the common bile duct is described. Apart from weakness and jaundice, the patient had no signs or symptoms until after endoscopic retrograde cholangiopancreatography, when cholangitis and septicaemia due to Pseudomonas aeruginosa developed. X-ray during endoscopy revealed a tumour obstructing the common bile duct and was assumed to be malignant. Because the patient was so old and her general condition had deteriorated, no treatment was given. Autopsy revealed a benign angioleiomyoma of the common bile duct and suppurative cholangitis, the latter obviously caused by the endoscopy.

Aged↗
PubMed1983

Ultrasonic scanning after percutaneous renal biopsy.

Renal ultrasonic scanning was performed before and after 57 consecutive kidney biopsies in order to assess the value of this method in the diagnosis of complications. One large and six small perirenal haematomas were found, corresponding to an incidence of 13%. This figure is considerably larger than the incidence found with conventional diagnostic methods, but smaller than with computed tomography. One hydronephrosis and a blood clot in the urinary bladder were also diagnosed. No clinically significant complications were missed. We recommend ultrasonography as the first diagnostic procedure when biopsy complications are suspected.

Adolescent↗
PubMed1983

Urography with iohexol. Comparison with metrizoate and iodamide.

Comparisons of the non-ionic medium iohexol with the ionic media Na-Ca-Mg metrizoate and meglumine iodamide, were performed in two separate trials. The difference in diagnostic properties between the media was not significant. There was a significantly lower frequency of subjective sensations after iohexol than after metrizoate, whereas the difference between iohexol and iodamide in this respect was small. Regarding other adverse reactions there was a small advantage in favour of iohexol compared with metrizoate, whereas iohexol caused significantly less adverse reactions than iodamide.

Adolescent↗
PubMed1979

Urography and isotope renography following renal transplantation.

The clinical yield from routine urography following renal transplantation was compared with that from isotope renography. In 50 recipients of renal transplants, 59 urograms and 55 renograms were studied. The most common pathologic finding at urography was renal papillary necrosis (in 6 patients). This condition had no obvious correlation with the further fate of the transplant. There were no other significant pathologic changes. It is concluded that isotope renography can be regarded as sufficient for routine follow-up. One baseline urogram is useful, but additional urographies should be carried out only when clinically indicated.

Creatinine↗
PubMed1979

Interobserver variation in the evaluation of radiologic changes of rheumatoid arthritis.

The variation between four radiologists in the evaluation of hand, wrist, and foot radiographs of rheumatoid arthritis was examined. The recognition of individual radiologic changes varied considerably as judged by the findings of the different observers. Erosion and joint space narrowing were interpreted more uniformly than soft tissue swelling and osteoporosis. When the radiographs were graded from 0 to 5 using standard reference radiographs, more than 90% of them were graded uniformly or with a difference of only one grade. The investigation has shown that when applying grading of rheumatoid arthritis according to standard reference radiographs, the interobserver variation is considerably less than when pure individual radiological changes of rheumatoid arhtritis are considered.

Adult↗
PubMed1978

A new relative contraindication for lumbar myelography.

We have taken myelograms of six patients with grave post-tuberculous thoracic gibbus of the spine and gross deformity of the thoracic cage. Two of these patients suffered violent convulsions and fracture of the neck of the femur. In one patient the myelogram was taken with Conray Meglumine and in another with Dimer X. We suggest that a grave deformity of the thoracic cage is a relative contraindication for lumbar myelography with these water-soluble contrast media. We assume that the reduced tissue oxygenation in these patients results in a lower threshold for convulsions.

Femoral Neck Fractures↗
PubMed1978

Angiography and isotope renography in acute rejection of renal transplant.

Isotope renography and transplant angiography were performed during 37 acute episodes of renal transplant rejection. Renography demonstrated rejection in 70% of the irreversible and 55% of the reversible processes. Angiography, though reliable in irrerversible rejection, was diagnostic in only 30% of the reversible cases. Renography is the method of choice for diagnosing rejection and its accuracy is improved by repitition. Angiography should be reserved for patients whose renal function is not restored by treatment for rejection.

Evaluation Studies as Topic↗
PubMed1977

Renal artery stenosis in hypertensive renal transplant recipients.

Reconstruction of a stenotic renal artery was done on 5 hypertensive renal transplant recipients, all of whom had deterioration of renal function when the stenosis was detected. After reconstruction renal function improved in 4 of the patients. The blood pressure was easier to control in all 5 patients, with 3 becoming normotensive. A high preoperative plasma renin activity returned to normal postoperatively in 4 patients. No recurrences were observed after a followup of more than a year.

Adult↗
PubMed1977

Prognostic value of angiography in early failure of renal transplants.

The angiographic findings in 18 patients with irreversible rejection and in 20 patients who regained satisfactory renal function were compared. In 13 of the 18 patients who lost their transplants the outcome was predictable from the angiographic appearances. The diagnosis of irreversibility was more accurate in patients whose transplanted kidneys never functioned and when angiography was performed not earlier than 4 days after the onset of clinical signs of rejection.

Evaluation Studies as Topic↗
PubMed1977

Early venous filling in transplanted kidneys.

Early venous filling in patients with renal transplants was found in the presence of ischaemic injury, acute rejection, and chronic rejection; thus it cannot be used in differential diagnosis. Early venous filling was present only when the cortical circulation was scored as adequate although when observed in acute or chronic rejection the prognosis for the graft was poor.

Acute Disease↗
PubMed1977

Arterial stenosis in renal transplantation.

Stenosis of the renal artery of the transplant (RAT), is reported with a frequency of 5-10% (Nerstrøm, Ladefoged & Lund 1972, Nilsson, Henriksson & Thoren 1976, Beachley, Pierce, Boykin & Lee 1976). The stenosis is significant if it deteriorates the renal function or elevates the arterial blood pressure. The angiographic impression of a stenosis depends on the projection and it is difficult to correlate the radiological findings with the blood flow. Moreover both renal failure and hypertension might depend on other factors than stenosis of the RAT. The aim of this study was to establish how often a reconstruction of a RAT suspected of being stenotic would benefit the patient.

Graft Rejection↗
PubMed1976

Magnification angiography in the evaluation of transplanted kidneys.

Conventional and magnification angiography were performed on 34 occasions in 31 patients with renal allografts. The differential diagnosis between acute rejection and tubular necrosis was uncertain. In chronic rejection, where vascular abnormalities dominate, the diagnosis was easier. The magnification angiography demonstrated the small intrarenal arteries to better advantage, resulting in a more accurate assessment of the condition.

Acute Disease↗
PubMed1976

Kidney function and compensatory growth of the kidney in living kidney donors.

Pre- and postoperative kidney size and kidney function were studied in 46 living kidney donors aged 20-74 years. Kidney size was measured by planimetry and by estimation of a renal index. Kidney function was assessed by endogenous creatinine clearance and serum creatinine. Planimetry was superior to the renal index for expressing changes in renal size. Compensatory renal hypertrophy took place in donors up to the age of 74, but the greatest changes in renal size were observed in donors of under 40. Total renal function decreased postoperatively to about 77% of the initial level; this change in renal function was inversely correlated with age, but in all subjects studied the function remained within normal limits.

Adult↗
PubMed1975

An X-ray study on the acute action of diphenoxylate on the intestinal motility in volunteers.

The intestinal inhibitory activity of 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidine-carboxylic acid ethyl ester (diphenoxylate) after a single oral dose of 5 mg was studied in 10 volunteers with X-ray diagnostic methods. The diphenoxylate treatment lengthened the transit time of the barium sulphate to caecum from 3.2 to 4.3 h. The X-ray cinematography showed the slower duodenal emptying in 5/10 of the subjects, but only in 1 of these the velocity of the peristaltic wave was clearly decreased. The results demonstrate directly the acute inhibitory action of diphenoxylate on intestinal motility with the dose used generally 3--4 times daily for the symptomatic treatment of diarrhoea.

Adult↗