Biomedical subjects

L L Yang

Publications and source records attributed to L L Yang.

75 records · Page 5Linked to original sources

PubMedDate not supplied

Neuropsychological and behavioral status of Chinese children with acyanotic congenital heart disease.

Thirty-nine children between the ages of 5 to 8 years (N = 27) and 9 to 14 years (N = 12) who were undergoing cardiac surgery for repair of ventricular or atrial septal defect and 39 controls matched for age, educational level and social class were administered the age-appropriate Chinese versions of the Wechsler Intelligence scales and the Halstead Reitan Neuropsychological test batteries. Parents completed the Achenbach Behavioral Rating Scale. Surgical subjects underwent extracorporeal circulation and hypotensive anesthesia. The intellectual development of children with heart disease was significantly lower than normal controls and showed particular impairment of complex integrative functions of the brain. Parents of surgical subjects also rated their children as having greater behavioral disturbance than did parents of healthy children. Acyanotic heart disease was found to both impact negatively neuropsychological and behavioral functioning.

Adolescent↗

PubMedDate not supplied

Reappraisal of occlusion therapy for severe structural abnormalities of the optic disc and macula.

The visual function of some children with structural defects of the macula or optic nerve has previously been shown to improve with occlusion therapy. The charts of five children, ages 4 to 8 years, who had various types of severe structural abnormalities were reviewed. Two patients had optic nerve hypoplasia; there was one case each of foveal hypoplasia, posterior persistent hyperplastic primary vitreous, and retinopathy of prematurity. All the patients had undergone extensive amblyopia therapy prior to referral. In three children, occlusion therapy had been initiated and continued intensively for several months or longer without recognizing the presence of a severe, underlying structural abnormality. In none of the five children was there any clear-cut evidence of visual improvement. In some cases, the long period of enforced iatrogenic vision impairment resulted in significant psychosocial harm and developmental delay. In all five cases, it was structural changes rather than amblyopia that ultimately accounted for visual loss. The authors stress the importance of a meticulous fundus examination directed at finding organic defects prior to patching. Close, periodic monitoring of visual function should then follow. To spare the child unnecessary psychosocial impairment, it is advisable to follow established recommended thresholds for terminating occlusion therapy.

Amblyopia↗

PubMedDate not supplied

Methemoglobinemia following metoclopramide therapy in an infant.

An infant with persistent vomiting was found to have methemoglobinemia. Review of his history revealed that he had been treated with metoclopramide. No other etiology of the methemoglobinemia was identified. It is concluded that the use of metoclopramide in a sick neonate can cause transient methemoglobinemia. Similar cases reported in the foreign literature are reviewed.

Humans↗