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Biomedical subjects

L L Miller

Publications and source records attributed to L L Miller.

At least 127 records · Page 7Linked to original sources
PubMed1977

Physical and behavioral aspects of sexual maturation in male golden hamsters.

Male golden hamsters (Mesocricetus auratus) were examined from 3 to 9 wk of age for morphological, physiological, and behavioral indices of sexual maturation. Although each of the eight variables selected for measurement displayed a unique developmental profile, a principal-components analysis of these variables resulted in the extraction of two principal components, one tentatively labeled physical and gross behavioral maturation (accounting for 66% of the total variance) and the other designated perfection of mounting orientation (accounting for an additional 12% of the variance). This result indicates that puberty in the male hamster is best viewed as two independent processes, rather than as a unitary process, or as an arbitrary term applied to a variety of unrelated developmental phenomena. Advantages of using multi-variate composite scores and selected univariate measurements are discussed; as are methods of comparing developmental changes in different variables. A second experiment confirmed an unexpectedly early onset of androgen secretion and an unusual pattern of body weight gain.

Age Factors↗
PubMed1976

Cognitive performance in conversion hysteria.

In order to test some neurobiologically based assumptions pertaining to attention and memory dysfunction in conversion hysteria, a series of tasks was given to 17 hospitalized patients with hysterical conversion reaction and to a control group of nonpsychotic patients under conditions of nonstress and stress. The results indicated significant differences in performance between hysteria and control subjects. The former group, in comparison to controls, had heightened suggestibility, greater field dependency, and greater impairment of recent memory and vigilance-attention. A discriminant analysis indicated the feasibility of using such tests as objective diagnostic criteria for hysteria.

Adult↗
PubMed1976

Direct effects of glucagon on protein and amino acid metabolism in the isolated perfused rat liver. Interactions with insulin and dexamethasone in net synthesis of albumin and acute-phase proteins.

The isolated rat liver perfused for 12 hours at pH 7.10 with a suspension of bovine erythrocytes in Krebs-Ringer bicarbonate buffer containing 3 per cent bovine serum albumin has been used as a test system to study effects of glucagon and of dexamethasone in the presence and absence of insulin on net biosynthesis of rat serum albumin, fibrinogen, alpah1-acid glycoprotein, alpha2-(acute phase) globulin, and haptoglobin. Quantitative measurement of perfusate glucose, amino acid nitrogen, and urea affords a basis for determining net glucose and nitrogen balance in the perfusion system. Although the dose of dexamethasone (total 1.0 mug.) used was insufficient to induce synthesis of alpha2-acute phase globulin, net syntheses of albumin, fibrogen, alpha1-acid glycoprotein, and haptoglobin were increased. Glucagon given with dexamethasone depressed albumin and haptoglobin synthesis markedly, but not that of fibrinogen and alpha1-acid glycoprotein. Glucagon with dexamethasone markedly enhanced ureogenesis and glycogenolysis and elicited an exaggerated negative nitrogen balance. The unfavorable effects of glucagon on albumin and haptoglobin synthesis and on nitrogen balance were reversed by giving insulin simultaneously. It is emphasized that insulin is essential for positive nitrogen balance.

Animals↗
PubMed1975

Serum antitrypsin synthesis by the isolated perfused rat liver.

The isolated perfused rat liver synthesizes antitrypsin activity in a linear fashion as long as 24 hr. The rate of synthesis may be ten times the rate necessary for physiologic levels in vivo. These data are compatible with the liver as the principal site of synthesis of serum antitryptic activity in the rat. The antitrypsin activity of the rat perfusate resembles that of normal human plasma in liability to heat (56 degrees) and to acid (below pH 6) and in apparent molecular size (elution from Sephadex G-200).

Animals↗