This study describes the age-targeted chemotherapeutic control of geohelminthiasis in the total population (n = 11,500) of the island of Montserrat, West Indies. The intervention programme involved the treatment with single dose albendazole of all children aged 2-15 years (approximately 2500) in 4 sequential cycles at intervals of 4 months. Infection status was monitored by an initial coprological survey of an age-stratified sample (11.5%) of the population, and by surveys of smaller samples (4-5%) after 2 and 4 cycles of treatment (7 and 15 months respectively). The programme delivered treatment to greater than 90% of the target population in each cycle, and reduced the prevalence and intensity of Ascaris lumbricoides and Trichuris trichiura infection in the target age-class. A decline in infection was also observed in the 16-25 year age-class, even though less than 4% of adults received treatment. The study demonstrates that chemotherapy targeted only at children can be implemented within an existing health infrastructure, and can achieve an overall reduction in the prevalence and intensity of geohelminth infection.

Adolescent↗

PubMedDate not supplied

Bone resorption levels by age and menopausal status in 5,157 women.

OBJECTIVE: The purpose of this study was to describe bone resorption activity using a biochemical marker according to the categories of age, menopausal status, and selected drug/supplement use in middle-aged and elderly community-based women. DESIGN: This was a cross-sectional study that assessed urinary cross-linked N-telopeptide of type I collagen (NTx) and used self-report data to group women as premenopausal (Pre), perimenopausal (Peri), postmenopausal without hormone replacement therapy (Post), and postmenopausal with hormone replacement therapy (HRT). RESULTS: Mean NTx values were found to be significantly different by group and controlling for age (p = 0.001), with post hoc tests showing all pairwise group comparisons as significantly different (p = 0.001), except that the Pre and HRT groups were not significantly different. Both the Peri and the Post NTx levels were significantly higher than the Pre and the HRT groups'. NTx values in the Peri group varied with age-the youngest Peri women were similar to Pre women, and the oldest Peri women were similar to Post women. Significantly lower NTx levels were found only in the Post (p = 0.009) and HRT (p < 0.001) groups using diuretics compared with nonuse and only in the HRT group using calcium supplements compared with nonuse (p = 0.006). No differences by thyroid use were found. With a biochemical marker, the results showed that bone resorption activity differences could be demarcated in women according to age, estimated menopausal stage, and selected drug/supplement use. CONCLUSIONS: These results support the usefulness of NTx assessment for indicating bone resorption activity and therefore the potential for osteoporosis or for monitoring the efficacy of antiresorptive therapies.

Adult↗

PubMedDate not supplied

A transcultural knight.

Explore the source record for details and available documents.

Australia↗

PubMedDate not supplied

One year in the life of a woman with premenstrual syndrome: a case study.

Over the course of 1 year (13 menstrual cycles), data were collected on a daily basis using Likert-scale ratings of symptom presence and severity, as well as narrative journal entries. The participant was a 37-year-old healthy woman (mean cycle length = 26.7 days, SD +/- 1.8) with prospectively screened well-defined premenstrual syndrome (PMS), not on hormones or other drugs, and without a psychiatric history. Using the autocorrelation function (ACF), there was evidence for a statistically significant predictive cycle-to-cycle symptom pattern (ACF r = .49, p < .05; Bartlett Band range of significance = +/- .13). Cycle-phase-dependent coexistence of symptoms was noted, along with particular narrative themes, most dramatically exemplified by the theme of death. For this subject, the findings provided evidence for predictive symptom patterns and an effect of symptom presence on her interpretation of her environment and herself.

Adult↗