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Biomedical subjects

L L Hart

Publications and source records attributed to L L Hart.

At least 19 recordsLinked to original sources
PubMed1998

Small-cell lung carcinoma: an analysis of 194 consecutive patients.

The treatment of small-cell lung carcinoma (SCLC) requires the careful combination of chemotherapy and radiation therapy. To understand the factors involved in the outcome of these patients, the authors undertook a study of patients treated for limited stage SCLC. The charts of 194 consecutive patients treated at our facilities between 1986 and 1994 were reviewed. All patients underwent thoracic radiation therapy (TRT), 50% received prophylactic cranial irradiation (PCI), and all but one received chemotherapy. The probability of survival at 5 years was 14%, and the disease-free survival (DFS) was 17%. Patients receiving a combination of platinum and etoposide (PE) and Cytoxan (Bristol-Myers, Evansville, IN, U.S.A.), Adriamycin (Adria Laboratories, Dublin, OH, U.S.A.), and Vincristine (Eli Lilly, Indianapolis, IN, U.S.A.) (CAV) experienced a DFS at 3 years of 31%, versus 14% for CAV only and 18% for PE only (p = 0.004). In a multivariate survival analysis, only PCI (p = 0.001), having received PE and CAV (p = 0.01), and response to treatment (p = 0.001) were significant. Radiation dose and field size did not influence outcome. The combination of PE and CAV chemotherapy produced the best results in our series. Unanswered questions regarding the optimal TRT dose, field size, and timing of TRT await the results of ongoing randomized trials.

Adult↗
PubMed1996

Discrimination learning decreases perceived similarity according to an objective measure.

UNLABELLED: Initial identification discriminations between two sizes and between two slants produced better overall performances on subsequent size and slant same-different discriminations, respectively. This size- and slant-specific transfer was due to an improvement on only the different pairs. Time-duration identification discriminations with the identical stimuli and response assignments improved neither overall same-different performances nor performances on different pairs. A good performance on different pairs relative to same pairs should indicate a low perceived similarity. The literature indicates that A-X and B-Y pairings produce a positive transfer on an A-versus-B discrimination when X and Y are relatively low in similarity, and also indicates that a low perceived (not physical) similarity improves discrimination learning. An increase in salience should have also improved performance on the same pairs. THE CONCLUSION: the initial discriminations decreased the perceived similarity of parts (size or slant). This decrease resembles perceptual contrast. A discrimination between two parts also seems to increase the extent to which each part is apprehended as a separate group. Therefore, the conclusion accords with the position that two groups are associated with contrast, including for visibility.

Adult↗