Effect of testosterone polydimethyl-siloxane implants upon sperm production, libido and accessory sex organ function in rabbits.
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Biomedical subjects
Publications and source records attributed to L L Ewing.
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Regulation of testosterone secretion is presumably mediated by interstitial cell-stimulating hormone (ICSH). However, there is little information on the actions of other chemical messengers in regulating testosterone secretion. We have shown that follicle-stimulating hormone augments testosterone secretion stimuated by ICSH in rabbit testes perfused in vitro with an artificial medium.
The soluble fraction of rat testis homogenates is rich in enzymes catalysing the phosphorylation by ATP of many different proteins. The phosphorylation of certain histones, and also of a homogeneous basic protein from guinea-pig seminal-vesicle secretion, is markedly enhanced by 3':5'-cyclic AMP. Various factors affecting these reactions as catalysed by partially purified testicular enzyme preparations are described, and their possible physiological significance is discussed.
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