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Biomedical subjects

L Kudrow

Publications and source records attributed to L Kudrow.

At least 19 recordsLinked to original sources
PubMed1992

Cluster headache.

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Cluster Headache↗
PubMed1991

Diagnosis and treatment of cluster headache.

This article classifies cluster headaches as distinct from other types of headaches and gives guidelines for diagnosis and treatment. Explanations of the pathophysiology and pathogenesis of cluster headaches are included also.

Cluster Headache↗
PubMed1990

Association of sustained oxyhemoglobin desaturation and onset of cluster headache attacks.

Ten episodic cluster headache patients in their active cluster period, ten patients in remission and five control subjects were monitored for minute to minute changes in oxygen saturation (SaO2) and pulse rate before and after nitroglycerin (NTG) administration. A transient but significant decrease in SaO2 and increase in pulse rate of 25 minutes duration occurred following NTG in all groups. These changes may reflect physiologic hemodynamic effects of NTG as a smooth muscle relaxant. Subsequently, SaO2 levels and pulse rate recovered to baseline values in remission and control groups. In contrast, SaO2 values in the active cluster group decreased further and after an extended period culminated in cluster headache attacks in 10/10 patients. Three major changes, therefore, distinguished active cluster patients from remission and control groups. First, the magnitude of oxygen desaturation increased after the physiological effects of NTG ceased. Second, oxygen desaturation was sustained for an additional 9 to 30 minutes duration. Third, the hypoxemic state culminated in attacks in all cases. Our findings suggest that the active cluster period may be characterized by an impaired mechanism to autoregulate, and thus compensate, for hypoxemia. It is further proposed that persistence of hypoxemia and the cluster attack onset may share a common mechanism, coupling the two events. We suggest that abnormal central and/or peripheral chemoreceptor activity may be responsible for these events.

Adult↗
PubMed1989

Successful aspirin prophylaxis in a child with chronic paroxysmal hemicrania.

It is generally recognized that indomethacin prophylaxis is the treatment of choice in adults with chronic paroxysmal hemicrania (CPH). Our case report is the first to demonstrate complete control of CPH in a 9 year-old child using small dose aspirin prophylaxis. This case also represents direct observation of the youngest patient with CPH having the earliest reported onset.

Age Factors↗
PubMed1976

[Changes of testosterone levels in the cluster headache syndrome. Preliminary study].

In a preliminary study, plasma testosterone values were obtained by the RIA method from 2 groups of cluster headache males at separate laboratories. Within each group the mean testosterone levels were compared between normal control and cluster patients in active and remission periods. Significantly lower values were consistently obtained from the active cluster patients when compared to either cluster-remission or normal control. The results of this preliminary study are interpreted as revealing a possible association of lowered plasma testosterone levels with the active cluster period in cluster headache syndrome.

Adult↗