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Biomedical subjects

L Kreel

Publications and source records attributed to L Kreel.

At least 91 records · Page 5Linked to original sources

Computed tomographic demonstration of "coronary" collateral vein calcification and patent spleno-renal shunt--a case report.

A case of hepatoma associated with previously treated portal hypertension and calcification of the portal veins, collaterals, and superior mesenteric veins was demonstrated by CT, as was the patent splenorenal shunt and ascites. Computed tomography successfully demonstrated all these aspects of the case by plain scans and the use of angiotomography with rapid sequential sections using the multiple bolus technique of contrast enhancement.

Aged↗

Cryptogenic fibrosing alveolitis: pattern of disease in the lung.

The distribution of disease has been studied in 10 patients with histologically confirmed cryptogenic fibrosing alveolitis by means of computed tomography of the lungs, gallium 67 uptake scintigraphy, and ventilation and perfusion scintigraphy. The findings of computed tomography and scintigraphy showed no correlation with the UICC/Cincinnati grades of the plain chest radiographs, even when these were supplemented with information from lateral and oblique chest films. Computed tomography showed subpleural shadowing in every patient except one who had responded well to corticosteroid treatment. Subpleural shadowing was commoner in the inferior and posterior parts of the lung lobes and was commonest in the posterior lower subpleural areas. The central lung showed three types of change--firstly, a dense shadowing, which was sometimes associated with much increased gallium uptake; secondly, dilated smaller airways with small bullae, suggesting airway disease; and, thirdly, gross bullous change.

Humans↗

The hepatic interlobar fissure: combined in vitro and in vivo study.

A densely echogenic line is seen connecting the right portal vein and the neck of the gallbladder on longitudinal views in at least 70% of sonograms. The origin of the line has been taken to be the fissure between the right and left lobes of the liver, but no documentation has been provided. Intact liver specimens were studied in a water bath; metallic markers were placed to coincide with the line under real-time guidance. The line does, indeed, correspond to the interlobar fissure. Factors affecting visualization include position of the gallbladder neck and orientation of the fissure as well as fat deposition within the fissure.

Adolescent↗

Computed tomography in gastroenterology.

Computed tomography detects mass lesions greater than 2 cm in diameter whether tumours, cysts, abscesses or granulomas but cannot usually distinguish between benign and malignant tumours or between cysts, old haemorrhage or abscess. Accurate localization, however, allows precise percutaneous aspiration or cytology. In gastroenterology it is used for disease in liver, pancreas, biliary system and spleen and, to a much lesser extent, in the gastrointestinal tract. Ultrasonography can frequently produce similar information and is much more readily available and cheaper. For tumour staging, CT is advantageous in showing all organs including soft tissues, lung, bone and subcutaneous tissue. Where ultrasonography fails for technical reasons, CT is invariably recommended and, when doubt exists as to the interpretation with ultrasonography, CT is undertaken (or vice versa). The management of malignant disease is improved by more accurate diagnosis and radiotherapy planning as well as more accurate monitoring of treatment with a non-invasive technique.

Colonic Neoplasms↗

Peripheral and axial measurements of trabecular bone density in patients suspected of idiopathic vertebral osteoporosis.

In 18 patients with idiopathic crush fracture syndrome, iliac trabecular bone volume measured in 8 mm trephine biopsies correlated well with trabecular bone density as estimated in low thoracic or high lumbar vertebrae by computed tomography (CT). The CT of trabecular bone in the radius correlated poorly with the other two measurements, but it discriminated fairly well between patients and age-matched controls. These results suggest that abnormally low trabecular bone density values in the radius may be useful in predicting some patients at risk for crush fractures, but ranking patients in order of severity of axial bone loss after they have acquired a fracture requires measurements on the spine or iliac crest.

Aged↗

Adult idiopathic pulmonary haemosiderosis: a comparison of lung function changes and the distribution of pulmonary disease in patients with and without coeliac disease.

Seven patients with idiopathic pulmonary haemosiderosis were investigated with chest radiographs, pulmonary function tests, computed axial tomograms, and isotope ventilation and perfusion scans. Three of the patients had coeliac disease (CD) and a fourth an abnormal small bowel mucosa under the dissecting microscope which was normal histologically. Five patients showed airflow limitation with a low transfer coefficient. Three of these had air trapping, two of whom had hyperinflation of the lungs, and the third a total lung capacity at the upper limit of normal. Two patients showed a central distribution of radiographic opacities, and the other five had changes throughout the lung fields. The presence or absence of CD showed no relationship to these findings.

Adult↗

Body computed tomography in the diagnosis of malignant melanoma metastases.

The results of body CT examination in 32 cases of histologically proven malignant melanoma are reviewed. In a total of 38 examinations, positive findings were obtained in 27 cases (71%). Metastases were detected in the lungs (6 cases), liver (2 cases), and lymph nodes (26 cases). Local recurrences were recognized in 2 cases. Clinical suspicion of metastases was supported in 19 cases (50%), suspected metastases were not confirmed in 5 cases (15%), and additional evidence of metastasis was obtained in 14 cases (37%). CT was of particular value in demonstrating additional metastases in the lungs and lymphadenopathy in the abdomen and pelvis.

Female↗

Computed tomography attenuation values in fatty liver.

The accuracy of CT diagnosis of increased fat deposition in the liver was assessed in 11 alcoholic patients with suspected fatty liver. Single-energy CT attenuation values were compared with histological assessment of fatty liver and chemical analysis of liver triglyceride concentrations, obtained from liver biopsy specimens. Measured attenuation values showed an inverse correlation with the degree of fatty change assessed histologically (r =--0.90; p Less Than 0.0001) and with that assessed chemically (r=--0.57; p Less Than 0.05). CT scanning may provide a useful non-invasive method for detecting and following patients with fatty liver, particularly when liver biopsy is contraindicated.

Adult↗

Role of computed tomography in the management of infectious disease.

All cases referred for computed tomography (CT) from a 48-bed infectious disease unit over a 3-year period were reviewed. Thirty patients were examined on 45 occasions with head and body cases approximately equal in number. Positive diagnoses were made in 38 examinations (84%), although this included 3 incidental findings. The most common indication for CT was exclusion of cerebral abscess presenting as meningitis (11 cases). The most common disease was tuberculosis (12 cases), although a wide spectrum of disease including four noninfective cases was encountered. CT made a direct contribution to the management of patients with meningitis, encephalitis, cerebral abscess, septicemia, hepatic abscess, tuberculosis, and lymphoma. Although CT was only utilized in a small proportion of patients admitted to this unit, the technique provided valuable information in the management of a number of problematic cases.

Abscess↗

Use of computed tomography to demonstrate the extent of tuberculosis.

A group of 15 patients with tuberculosis was investigated by computed tomography to document the extent of the disease at the time of diagnosis. This was compared with information available from the clinical examination. Of the 33 sites of disease shown by CT (confined to the thorax and abdomen), only 17 had been demonstrated by clinical examination and chest x-ray. In addition, 7 patients had cervical lymphadenopathy (an area not scanned). CT shows tuberculosis to be more extensive than would be appreciated by conventional investigation. We think this argues against classifying the disease according to presenting anatomical site.

Humans↗