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Biomedical subjects

L Koulischer

Publications and source records attributed to L Koulischer.

114 records · Page 7Linked to original sources
PubMedDate not supplied

The hamster test in a series of 120 infertile patients.

The value of a test based on penetration of human sperm into zona-free hamster ova is evaluated by the authors. Rudak's technique was used in 120 infertile patients. The Authors affirm that the hamster test is at present the only practical functional test for the evaluation of the fertilizing capacity of human spermatozoa and that it will probably be more widespread in the future.

Adult↗
PubMedDate not supplied

[Germ cell tumour and pseudohermaphroditism. Histological and cytogenetic study (author's transl)].

The case report is that of a 15 years old boy presenting with unilateral undescended testis and hypospadias. Surgical exploration disclosed an absence of regression of the Müllerian system and an intra-abdominal gonad replaced by a seminoma. There are arguments to suspect that the seminoma arose from a gonadoblastoma controlateral testis biopsy disclosed a germ cell abnormality consistent with an in situ neoplastic transformation. It is emphasized that all forms of cryptorchidism must be explored surgically and that apparently normal gonads left in place in cases of unilateral gonadic dysgenesis, must be attended with extreme care.

Adolescent↗
PubMedDate not supplied

[Origin and sites of action of inhibin (author's transl)].

Mice testis in organ culture (31 degrees C) produce a steroid free substance which inhibits FSH secretion by rat pituitary cells. Histologically, Sterloti cells alone remain normal after a few days in culture. A hypothalamic action of inhibin is demonstrated in vitro. The intraglandular content in LHRH is inversely related to the amount of inhibin present in the culture medium. In the testis, DNA synthesis is depended of inhibin. This is demonstrated by studies of the incorporation of tritiated thymidine in testicular DNA in vivo and in vitro. In conclusion, inhibin is produced by Sertoli cells and acts not only at this pituitary level but also on the hypothalamus and the testis.

Animals↗