In this research one case of chronic myelogenous eosinophilic leukemia (pbe) transformed into myeloblastic crisis in male patient aged 24, efficiently treated chemotherapy with following performing allogenic bone marrow transplantation was represented. The patients was admitted to the Department of Hematology with the cause of increased leucocytosis (up to 19.9 x 10(9)/l), eosinophilia (up to 15.3 x 10(9)/l), enlarged percentage of eosinophillic granulocytes in bone marrow, splenomegaly, anaemia and thrombocytopenia. Cytogenetic tests did not reveal any chromosomal disturbances, and PCR test did not detect bcr/abl rearanzation. After 7 monthly period of chronic phase of disease there was appeared symptoms of blastic acceleration myelogenous disease i.e. enlargement of splenomegaly, intensification of anaemia and thrombocytopenia, very fast increasing leucocytosis in short time together with presence of myeloblasts in blood and bone marrow smear tests. Blastic acceleration pbe with eosinophils dominant in bone marrow was confirmed by flow cytometry. Induction chemotherapy according to schedule HAR (Hydroxyurea--H, Arabinoside Cytosine--A, Doxorubicin--R), consolidation and irradiation of spleen allowed to receive complete remission. The patients was undergone allogenic bone marrow transplantation (allo-BMT) from related donor (younger brother). The follow-up with the period 18 months after allo-BMT has not revealed the relapse of disease.

Adult↗

PubMedDate not supplied

[Intracellular cAMP concentration in isolated cells of white blood cell series of peripheral blood and bone marrow in healthy subjects and patients with different proliferative syndromes].

The level of cAMP was determined in isolated cells from bone marrow and peripheral blood of healthy subjects and patients with proliferative syndrome (acute and chronic myeloid leukaemia and chronic lymphatic leukaemia). In the investigations tritiated cAMP (3H-cAMP) was used and for binding of endogenous as well as exogenous cAMP protein isolated from bovine muscles was used. The mean cAMP level in peripheral blood granulocytes of healthy subjects was 27.90+/-3.82 pmol/10(7) cells and in normal lymphocytes it was from 11 to 18 pmol/10(7) cells. Much higher concentrations of cAMP: 56.4+/-16.25 and 52.7+/-11.02 pmol/10(7) cells were observed in myelocytes and metamyelocytes isolated from the bone marrow of healthy subjects. Lowering of cAMP concentration (below 4 pmol/10(7) cells) was observed in the lymphocytes of patients with chronic lymphatic leukaemia, while a higher cAMP concentration (above 90 pmol/10(7) cells) was found in the myeloblasts of patients with acute myeloid leukaemia.

Bone Marrow↗

PubMedDate not supplied

[Skin changes in Hodgkin's disease. Case report].

A case of Hodgkin's disease was observed in the Warsaw Institute of Haematology. Involvement of the skin developed ++during uncontrolled and refractory pathological process, despite multiple changes of cytostatic programmes. The histological type of the lesions, nodular sclerosis, suggested a milder course of the disease.

Adult↗

PubMedDate not supplied

[Long-term follow-up of children with chronic idiopathic thrombocytopenia after splenectomy].

On the ground of follow-up extended over many years the effectiveness was analysed of splenectomy in 93 children with idiopathic thrombocytopenia. Good and very good results of splenectomy were achieved in 84.95% of the cases treated surgically, in 15.05% no remission developed. In 27 splenectomized children recurrences appeared from 1 to 18 years after splenectomy. In 77.8% of cases the recurrences were transient, while in the remaining children qualified into the group with absent remission recurrences persisted throughout the whole follow-up period. In 3 children with unsatisfactory result of splenectomy accessory spleen was removed during repeated laparotomy, in two of them cure was obtained. No greater complications connected directly with the operation were noted. Severe viral and bacterial infections from 2 to 3 years after splenectomy developed in 3 children (3.23%) in 2 cases they were the cause of death (2.15%). Of decisive importance for good prognosis in children with this disease treated by splenectomy was normalization of platelet count immediately after the operation, preoperative disease duration not longer than 12 months, age below 10 years at the time of splenectomy, female sex, and spleen-liver index over 3.4.

Adolescent↗

PubMedDate not supplied