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Biomedical subjects

L Koch

Publications and source records attributed to L Koch.

At least 55 records · Page 3Linked to original sources
PubMed1984

[A method for the determination of the osmotic fragility of erythrocytes].

A method for registration of the haemolysis of erythrocytes as a measure for their osmotic resistance is presented. The technical realization is performed by means of a cuvette head-piece for holding a filter, which separates the investigation material from water. A cuvette insertion guarantees the regular construction of a haemoglobin gradient, serving as a measure for haemolysis, which is photometrically measured in the Spekol (VEB Carl Zeiss JENA) and registered by means of the compensation tape writer G 1 B 1 (VEB Carl Zeiss JENA). 0.3-0.4 ml investigation material are used. The expenditure of time amounts to about 20 minutes.

Hemoglobinometry↗
PubMed1984

[Interaction of solvent effects on the plasma membrane].

The combined effect of trichloroethylene and butanol on the behaviour of human erythrocytes during haemolysis in hypotensive milieu was investigated in comparison to the individual effects of solvents. In these cases, among others, appeared statistically significant quantitative changes of the maximum of stability. In a common influence of trichloroethylene and butanol and additional stabilisation of the membrane may be the result, which is traced back to various places of effect of the solvents. When 150 mmol/l butanol are used the haemolysis is suppressed by trichloroethylene in its concentration region of 8-10 mmol/l. This effect can be explained by additional inclusion of trichloroethylene in butanol-free lipid classes. When 200 mmol/l butanol are given the haemolysis much increases already at an application of 4 mmol/l trichloroethylene. Here trichloroethylene cannot infiltrate into other still butanol-free lipid classes, in order to evoke an additional stabilisation. On the contrary, in cooperation the decomposition of the crystal structure of the lipids (emulsification) and thus the haemolysis develops. These results refer to the fact that combined effects of solvents are not always to be valuated additively.

Butanols↗
PubMed1978

[Evaluation of exposure level in the handling of explosives].

For the clarification of a supposed case of poisening by handling of explosives containing nitric acid ester in a man who was an expert in performing explosions the proof of the exposition was necessary. By the determination of free nitrite in the blood as well as by measuring of blood pressure and pulse in persons exposed in the same way the intake of nitrated constituents of the explosive could be made clear. The advantage of the determination of free nitrite in the blood in contrast to the determination of the met-Hb is discussed. It is referred to an additional potential endangering by gun fumes and the measures for the protection of labour which are to be derived from this.

Adult↗