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Biomedical subjects

L Karalliedde

Publications and source records attributed to L Karalliedde.

25 records · Page 2Linked to original sources
PubMed1988

Acute organophosphorus insecticide poisoning in Sri Lanka.

Records of 92 cases of acute organophosphorus (OP) insecticide poisoning were analysed. Of the patients 91% were under 30 years of age and 86% were males. The common agents were Dimethoate, Methamidophos, Malathion, Monocrotophos and Fenthion. Poisoning was due to ingestion with suicidal intent in the majority. In addition to the acute cholinergic features, the other important manifestations were delayed onset respiratory paralysis and delayed polyneuropathy. The overall mortality was 18%.

Adolescent↗
PubMed1988

Pattern of acute poisoning in a medical unit in central Sri Lanka.

One hundred and seventy nine cases of acute poisoning constituting 1.1% of all admissions to the medical unit over 3 years were analysed. Eighty-three per cent of the patients were under 30 years of age and 72% were males. The common agents were: OP insecticides in 51%, kerosene oil in 12%, rat poison in 8% and drugs in 8%. Ingestion with suicidal intent was the common mode of poisoning. The overall mortality was 16%. The results from four other major centres in Sri Lanka are presented for comparison.

Acute Disease↗
PubMed1988

Acute organophosphorus insecticide poisoning during pregnancy.

Intoxication with organophosphorus insecticides following ingestion with suicidal intent in two patients who were in the second and third trimesters of pregnancy is reported. Successful management of the cholinergic and intermediate phases of poisoning enabled each pregnancy to proceed to term and end in normal vaginal delivery of a healthy baby.

Adult↗
PubMed1987

Neurotoxic effects of organophosphorus insecticides. An intermediate syndrome.

Acute neurotoxic effects during the cholinergic phase of organophosphorus insecticide poisoning and delayed neurotoxic effects appearing two to three weeks later are well recognized. We observed 10 patients who had paralysis of proximal limb muscles, neck flexors, motor cranial nerves, and respiratory muscles 24 to 96 hours after poisoning, after a well-defined cholinergic phase. The compounds involved were fenthion, monocrotophos, dimethoate, and methamidophos. Four patients urgently required ventilatory support. The paralytic symptoms lasted up to 18 days. A delayed polyneuropathy later developed in one patient. Three patients died. Electromyographic studies showed fade on tetanic stimulation, absence of fade on low-frequency stimulation, and absence of post-tetanic facilitation, suggestive of a postsynaptic defect. This neuromuscular junctional defect may have been the predominant cause of the paralytic symptoms, with neural and central components contributing to various degrees. Our patients appeared to have a distinct clinical entity (a so-called intermediate syndrome) that developed after the acute cholinergic crisis and before the expected onset of the delayed neuropathy.

Adult↗