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Biomedical subjects

L K Sharma

Publications and source records attributed to L K Sharma.

At least 37 records · Page 2Linked to original sources
PubMed1986

Peritoneoscopy in extrahepatic abdominal diseases.

Results of peritoneoscopy performed under local anesthesia were reviewed in 43 consecutive patients with predominantly extrahepatic disease. Patients with previous laparotomy scars and poor general condition were not refused the benefits of this procedure. Diagnostic accuracy was 84%. Histologic diagnosis was achieved in 42% of patients and cholecystocholangiography under peritoneoscopic guidance in two jaundiced patients. Laparotomy was avoided in 65% of patients, and peritoneoscopy correctly assessed local extent of gastric neoplasia in 76% (16/21). Complications were insignificant. Peritoneoscopy under local anesthesia is a quick, accurate, economic, and safe method for evaluating extrahepatic abdominal disease.

Abdomen↗
PubMed1986

Postoperative wound infection in a pediatric surgical service.

Seventy-two out of 1,325 consecutive pediatric patients (5.43%) developed an operative wound infection in a general pediatric surgery unit. The wound infection rate was observed to be highest in neonates (13.75%) as compared with the children over 5 years of age (2.93%). The increased susceptibility of newborns to wound infection was found to be statistically significant. Patients operated for gastrointestinal problems and solid abdominal neoplasms had the highest wound infection rate.

Adolescent↗
PubMed1986

Obstruction of the third part of the duodenum in tuberculosis.

Extrinsic compression by tuberculous mesenteric nodes is the rarest form of duodenal obstruction and one such case is presented. Radiology is helpful in differentiating various duodenal lesions. Ideal surgical treatment is duodeno-jejunostomy but in some cases only gastroenterostomy is possible.

Duodenal Obstruction↗
PubMed1986

Comparative ultrastructure of cancerous and normal human breast cells: demonstration of cytoskeleton by TEM.

A technique for the study of the cytoskeleton by transmission electron microscopy is described. It preserves cytoplasmic and nuclear ultrastructural details as well as cytoskeletal elements enabling a correlated study. There are no significant differences in organization and distribution of intermediate filaments between cancerous and normal breast cells. Close association between cytokeratin filaments and cell structures has been established from stereotilted images. Cytokeratin filaments in contact with cell structures are in the form of bundles; in the free 'space' of cytoplasm meshworks are organized. The intermediate filament system could possibly be organized for participation in diverse functions in a cell.

Breast↗
PubMed1985

Typhoid enteric perforations.

Forty-five cases of typhoid enteric perforation are presented. The disease was most common in young males. Half of the perforations occurred during the second week of fever. Diagnosis was mainly clinical, supplemented by radiological evidence of pneumoperitoneum and confirmed at laparotomy by the presence of perforations in the terminal ileum. Laboratory investigations including Widal perforations in the terminal ileum. Laboratory investigations including Widal test and blood culture were of little value. All the 45 were managed operatively by simple closure of the perforation(s) and drainage of the peritoneal cavity. Burst abdomen occurred in 9 per cent and fecal fistula in 20 per cent. Overall mortality was 11 per cent--much lower than that reported in the literature in case of management of typhoid enteric perforations.

Adolescent↗