Bupropion and compulsive behavior.
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Attention Deficit Disorder with Hyperactivity↗
Biomedical subjects
L K Jacobsen
Publications and source records attributed to L K Jacobsen.
Interviewing prepubertal children about suicidal ideation and behavior.
OBJECTIVE: Much of the literature on assessment of suicidal children has focused on identifying risk factors associated with suicidal ideation and behavior in this population. Unique problems encountered in interviewing prepubertal children about suicidal ideation and behavior are examined in this paper. METHOD: Observations of problems encountered in interviewing prepubertal children about suicidal ideation and behavior were gleaned in the context of interviews of children admitted to a child psychiatry inpatient unit and interviews of the parents of these children. RESULTS: Unique problems include difficulties in assessment of suicidal intent, impact of cognitive development, particularly of the concept of death, interaction between current emotional state and memory of previous suicidal episodes, characteristics of play associated with suicidal states, effects of parents' attitudes toward assessment on information gathering, and the impact of certain risk factors on cognition and behavior during the interview. CONCLUSION: Interviewing children about suicidal ideation and behavior necessitates that the clinician attend to multiple elements of the interview simultaneously. These interviews are further complicated by the stressful thoughts and feelings that can be raised in both clinician and child in reaction to exploring the child's suicidal ideation and behavior. Additional research is needed to refine the process of reliable interviewing of children about suicidal ideation and behavior and to develop instruments both to quantitate the different elements of these interviews and to guide the clinicians conducting them.
Adolescent↗
Clozapine in the treatment of a young adolescent with schizophrenia.
Although recent reports have suggested that clozapine may be efficacious in the treatment of adolescents with schizophrenia, few studies have examined the use of clozapine in patients younger than 17 years of age. We describe highly successful trials of clozapine conducted in a 13-year-old girl and her cousin, both of whom developed severe symptoms of schizophrenia, which were refractory to neuroleptic medication, at the ages of 11 and 13 years, respectively. The pharmacology of and clinical experience with clozapine are reviewed.
Adolescent↗
Naloxone challenge as a biological predictor of treatment outcome in opiate addicts.
Thirty seven consecutive applicants to methadone maintenance were assessed for depression and for level of opiate dependence using a 0.8-mg naloxone challenge. Nineteen of the applicants met DSM-III-R criteria for current major depression. At 3-month follow-up, high naloxone challenge test (NCT) scores at intake (high levels of opiate addiction) were found to predict poor program retention and elevated symptoms of depression at follow-up. Reports of heavy current drug use at intake were also associated with poor program retention and with high frequencies of positive urine screens for illicit substances during treatment. Level of addiction and reported amount of drug use at intake independently predicted program retention with a multiple correlation of 0.46 (P less than .01). Although NCT predicted depression at follow-up, depression at intake did not significantly predict treatment outcome, and NCT score predicted outcome independently of psychopathology.
Arousal↗
Severity of precipitated opiate withdrawal predicts drug dependence by DSM-III-R criteria.
Drug diagnoses in DSM-III-R are based on the dependence syndrome concept which hypothesizes that dependence on drugs is defined by behavioral and physiological changes but is separate from the social problems related to drug use. Previous studies provide support for the dependence syndrome in drug use; however, no study has examined whether biological indications of addiction are related to the dependence syndrome. The present study tests this relationship in 52 opiate addicts who were administered the Naloxone Challenge Test. The severity of withdrawal was correlated positively with the opiate dependence score, derived from the number of DSM-III-R criteria met. We also found that opiate withdrawal was inversely related to cocaine dependence and unrelated to any other drug use. Opiate withdrawal was not correlated with a global measure of social problems or to frequency or length of drug use. Our results support the validity of the dependence syndrome in opiate addiction because dependence is correlated with severity of withdrawal, is fairly specific to the drug, and is not related to social problems.
Adult↗