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Biomedical subjects

L Judkiewicz

Publications and source records attributed to L Judkiewicz.

64 records · Page 4Linked to original sources
PubMedDate not supplied

[Familial occurrence of Glanzmann thrombasthenia].

Glanzmann's thrombasthenia, known also as Glanzmann's disease, is an autosomally inherited hemorrhagic disease with unique abnormalities of platelet functions. Authors present a large family in which Glanzmann's disease was diagnosed in the father and two sons. An analysis of platelet membranes enabled diagnosis of Glanzmann's thrombasthenia type II. A decrease in clot contractibility, fibrinogen binding to blood platelets, and decreased glycoprotein IIb and IIIa levels with marked impairment of GP IIb and IIIa complexes formation were characteristic for affected family members. One daughter died 8 days after birth with the symptoms of hemorrhagic diathesis. Mother and remaining three sons are healthy without the signs of Glanzmann's disease.

Adolescent↗
PubMedDate not supplied

[Subcutaneous injections and intravenous infusion of sodium salt of heparin in the treatment of thrombosis of deep veins of the lower extremities].

Ninety-four patients with deep vein thrombosis of inferior limbs were randomly allocated to receive sodium heparin either by subcutaneous injections or by continuous intravenous infusion for six days. No significant difference was observed in the therapeutic efficiency as judged by phlebographic examinations and in rate of symptomatic pulmonary embolism between the two groups. There was one instance of major bleeding in the subcutaneous group. Minor bleedings occurred in 10 of the 48 patients treated with subcutaneous heparin and in 13 of the 46 patients receiving intravenous heparin. The results showed that subcutaneous injections of sodium heparin are as effective and safe as continuous intravenous infusion of this drug in the treatment of deep vein thrombosis.

Adult↗
PubMedDate not supplied

[Heart valve prosthesis, anticoagulants and pregnancy].

Patients with artificial valve prostheses require lifelong anticoagulation treatment. The risk of thrombotic complications increases greatly in pregnancy. Anticoagulant treatment in pregnant women with artificial heart valve prostheses in one of the most controversial problems in medical practice as anticoagulants which are beneficial and safe for the mother may by hazardous for the fetus. Recommended procedure is to administer heparin subcutaneously at last during the first 14 weeks and the last 2 weeks of gestation and coumarin derivates throughout the second and third trimesters. In asymptomatic or mildly symptomatic women who are willing to follow a strict regimen of antithrombotic prophylaxis in pregnancy the risk is not associated with an increased morbidity or mortality in the mother or fetus. Hence, recommendations against pregnancy in women with artificial heart valves are not always justified.

Coumarins↗
PubMedDate not supplied

[Platelet aggregation in migraine and other headaches].

In 43 patients with migraine, 20 with Horton's headaches, 13 with trigeminal neuralgia and 50 healthy subjects the circulating platelet aggregates were determined by the method of Wu and Hoak. Moreover, in 23 patients with migraine, 8 with Horton's headache and 21 healthy subjects spontaneous platelet aggregation was determined in platelet-rich plasma with a transmission aggregometer. It was found that the aggregation coefficient was much lower in patients with migraine and Horton's headache than in the control group. In the group with migraine the per cent of spontaneous aggregation in 8 patients differed significantly from the mean value which was similar to that in the control group or in the group with Horton's headache. In the light of these results the authors conclude that significant changes of platelet aggregation occur in migraine and Horton's headache.

Blood Platelets↗
PubMedDate not supplied

Reaction of lymphocytes to phytohemagglutinin in vitro in hereditary microspherocytosis.

The authors report results of investigations on PHA-stimulated blastic transformation of lymphocytes in hereditary microspherocytosis. In 25 patients with this disease including 12 splenectomized cases and 13 non-splenectomized ones a significant decrease of the blastic and mitotic indexes was observed in relation to a control group of 20 subjects. No statistically significant differences were noted, however, between the cases before and after splenectomy. The results indicate that splenectomy is not the only factor impairing blastic transformation in these patients. The authors suggest that in microspherocytosis changes exist not only in the erythrocyte membrane, but that similar changes in the lymphocyte cell membrane may impair the response to phytohemagglutinin (PHA).

Adolescent↗