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Biomedical subjects

L Jerome

Publications and source records attributed to L Jerome.

At least 19 recordsLinked to original sources
PubMed2001

Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia.

Complex genetic and biochemical interactions between HOX proteins and members of the TALE (i.e., PBX and MEIS) family have been identified in embryonic development, and some of these interactions also appear to be important for leukemic transformation. We have previously shown that HOXA9 collaborates with MEIS1 in the induction of acute myeloid leukemia (AML). In this report, we demonstrate that HOXB3, which is highly divergent from HOXA9, also genetically interacts with MEIS1, but not with PBX1, in generating AML. In addition, we show that the HOXA9 and HOXB3 genes play key roles in establishing all the main characteristics of the leukemias, while MEIS1 functions only to accelerate the onset of the leukemic transformation. Contrasting the reported functional similarities between PREP1 and MEIS1, such as PBX nuclear retention, we also show that PREP1 overexpression is incapable of accelerating the HOXA9-induced AML, suggesting that MEIS1 function in transformation must entail more than PBX nuclear localization. Collectively, these data demonstrate that MEIS1 is a common leukemic collaborator with two structurally and functionally divergent HOX genes and that, in this collaboration, the HOX gene defines the identity of the leukemia.

Acute Disease↗
PubMed1994

A comparison of American and Canadian teachers' knowledge and attitudes towards Attention Deficit Hyperactivity Disorder (ADHD).

The purpose of this study was to compare and contrast American and Canadian teachers' knowledge and attitudes regarding ADHD. Both samples completed a self report questionnaire. The first part determined the demographic background of the teachers. The second section consisted of 20 true/false questions concerning ADHD intended to assess teachers' general knowledge of the essential concepts involved in the diagnosis and treatment of the disorder. The results indicated that both samples had little in-service training regarding ADHD. Despite this, most teachers regarded ADHD as a valid diagnosis with educational implications and wanted more formal training. While most teachers did well on knowledge-based questions regarding the etiology and educational implications of the condition, many still perceived non-medical therapies such as diets as being effective. Many regarded the condition as being outgrown at adolescence. Significantly, only 14% of the teachers had been involved in the diagnosis and ongoing monitoring of mediation by outside professionals. The implications of improved in-service training for all professionals involved with children with ADHD are discussed.

Adolescent↗