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Biomedical subjects

L Jacobson

Publications and source records attributed to L Jacobson.

At least 217 records · Page 12Linked to original sources
PubMed1978

Transcutaneous Po2 monitoring in neonatal intensive care.

The transcutaneous Po2 monitoring technique was applied in 20 newborns. The method proved reliable during hypoxemia, normoxemia and hyperoxemia, with a high correlation between Ptco2 and Pao2 in simultaneously obtained arterial samples. Although Ptco2 reliably reflects changes in Pao2, occasional arterial samples are still required for establishing the relationship between Ptco2 and Pao2, especially in patients with impaired circulation. When this relationship has been determined, the therapist may rely on the recorded Ptco2 level for hours, given that the energy supply required to maintain the electrode at a preset temperature level remains constant. A considerable difference between Ptco2 and Pao2 or a change in the energy supply level to the electrode may alert the therapist to check the patient's circulatory status. The Ptco2 technique is now fully developed and can be recommended for use in neonatal intensive care.

Blood Gas Analysis↗
PubMed1977

[pH analysis].

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Acidosis↗
PubMed1977

Monitoring of transcutaneous PO2 in the fetus and mother during normal labor.

Transcutaneous PO2 (tcPO2) measurement is a non-invasive method which gives continuous information about central PO2. The method has previously been testes primarily on newborns and adults, and reports on the applicability of the method on the fetus during labor are still scanty and restricted to case reports. This paper reports on a systematic study of intrapartum fetal and maternal tcPO2-monitoring. The material is comprised of 19 parturients, the majority being nulliparae. All fetal presentations were vertex. The tcPO2 recordings averaged one hour in duration (Tab. I). FHR was recorded simultaneously. In 12 cases the electrode was affixed with glue, and in 7 cases a suction device was used for fixation. The electrode was attached when the cervix was dilated 4 to 6 cm. The mean tcPO2 was 20 mm Hg in the beginning of the registration, and showed a small decline in level throughout labor reaching 14 mmHg at the end of the registration period (Fig. 5). These values are in good agreement with those found by other authors in previous investigations. In some of the present cases, very low tcPO2 values were recorded. The relevance of these low tcPO2 values is unclear, and it is impossible to determine to what extent these tracings have true physiological relevance versus might be due to technical factors.

Electrodes↗
PubMed1977

Transcutaneous monitoring of PO2 in different skin areas in the neonate and in the scalp of the fetus during labor - methodological and physiological observations.

The reliability and physiological significance of continuous non-invasive PO2 recording by means of skin electrodes was studied by comparing simultaneous tracings from different skin areas in a series of 40 newborns with normal labor and birth. A new measuring equipment - the Radiometer prototype unit TPM 1 - was used. In addition, the applicability of the method to the fetus was tested in a primary series of 11 labor cases. Certain technical and physiological factors that can influence the tracings were identified.

Electrodes↗
PubMed1975

Influence on fetal carbohydrate and fat metabolism and on acid-base balance of glucose administration to the mother during labour.

Parturients during normal labour were given glucose. The maternal-fetal difference of glucose increased with increasing maternal glucose level. Glucose load caused a rapid early response of maternal insulin release. A parallel rise in plasma lactate and pyruvate occurred in both fetus and mother. The basal maternal hydroxybutyrate and glycerol concentrations decreased significantly during glucose load. The study demonstrated that at term, components of lipid metabolism in fetal and maternal plasma-in contrast to glucose -vary independently. No major disturbances of the fetal acid-base balance were found.

Acid-Base Equilibrium↗
PubMed1975

Intravascular coagulation in pregnancy--treatment with heparin.

Two pregnant women with a history of miscarriages or premature labour are described. In the 25-27th week of pregnancy routine examinations showed high levels of FDP in serum. Subsequent extensive coaggulation studies revealed a positive ethanol gelation test, low levels of firbrinogen, plasminogen, alpha2-macroglobulin and P&P and high level of AHF related protein for the stage of pregnancy, i.e. finding indicating abnormal proteolysis with activation of the coagulation and fibrinolytic system. Continuous intravenous heparin treatment caused the coagulation system to return to normal throughout the rest of pregnancy. Both women gave birth to healthy babies without any complications. But the placenta showed numerous infarcts. The heparin treatment may have prevented later developing of placental dysfunction.

Adult↗