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Biomedical subjects

L J Weber

Publications and source records attributed to L J Weber.

At least 37 records · Page 2Linked to original sources

Comparative oxygen affinity of fish and mammalian myoglobins.

Myoglobins from rat, coho salmon (Oncorhynchus kisutch), buffalo sculpin (Enophrys bison) hearts, and yellowfin tuna (Thunnus albacares) red skeletal muscle were partially purified and their O2 binding affinities determined. Commercially prepared sperm whale myoglobin was employed as an internal standard. Tested at 20 degrees C, myoglobins from salmon and sculpin bound O2 with lower affinity than myoglobins from the rat or sperm whale. Oxygen binding studies at 12 degrees C and 37 degrees C suggest that this difference is adaptive, permitting myoglobins from cold-adapted fish to function at physiologically relevant temperatures. Taken together, purification and O2 binding data obtained in this study reveal a previously unrecognized diversity of myoglobin structure and function.

Animals↗

Effects of neuromuscular blocking agents and acetylcholinesterase inhibitors on the response of pectoral fin muscle of the sculpin (Enophrys bison) to indirect stimulation.

The neuromuscular junction of the buffalo sculpin (Enophrys bison) was characterized in situ by examining the effects of various neuromuscular blocking agents and acetylcholinesterase inhibitors (ACHE-I) on pectoral muscle response to indirect stimulation. The injection of either d-tubocurarine (350 micrograms/kg) or alpha-bungarotoxin (alpha-Butx) (1 mg/kg) resulted in a flaccid paralysis. The depolarizing agents, succinylcholine (11 micrograms/kg) and decamethonium (42 micrograms/kg), produced a spontaneous contraction. The administration of the ACHE-I, diisopropyl fluorophosphate (DFP), and eserine resulted in responses which were contrary to those expected based on similar experiments using mammalian skeletal muscle. Twitch potentiation did not occur and the ability to maintain a tetanic response was not abolished even after the administration of clearly lethal concentrations of ACHE-I.

Acetylcholinesterase↗

Infant treatment decisions: ethics and cost.

Though society has been conditioned to believe that cost should not enter into medical care decisions, moral reasons do exist for considering cost in treatment decisions. Ethicists traditionally have distinguished between ordinary, or morally obligatory, means of preserving life and extraordinary, or morally optional, means. Treatment that offers a reasonable hope of benefit to the patient without excessive pain, expense, or other inconvenience would be considered ethically ordinary. Treatment that can not be obtained without excessive expense, which could greatly burden the patient's family and deprive them of other goods, could be legitimately withheld. The principle of proportionality, which requires balancing the probability and extent of potential harm against the probability and extent of good, also has been applied to medical care decisions. It has been used to focus attention on the cost of technologies and policies. Some have argued, however, that the individual patient--not a larger social good--should be the physician's only concern. Society should recognize that doing everything possible to save everyone who might survive leaves fewer resources to meet the needs of the poor and the disadvantaged. One way to limit the costs of intensive care, therefore, would be to limit the availability of neonatal treatment facilities. Infants would thus have to be selected for treatment according to prospects for survival or other medical indicators. Before society cuts back on infant care, however, it must address the question of justice. Since many low-birth weight babies are born to poor families, withholding infant treatment in some cases might increase, rather than reduce, the inequalities that already exist in health care delivery.(ABSTRACT TRUNCATED AT 250 WORDS)

Abnormalities, Multiple↗

Health care institutions face issues of justice, need.

Health care facilities, although founded to provide important services, should not rest content. Commitment to justice requires continued efforts in furthering cost containment, patients' dignity, equitable compensation, and full participation in decision making and in combating racism and sexism.

Freedom↗