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Biomedical subjects

L J Rubinstein

Publications and source records attributed to L J Rubinstein.

At least 145 records · Page 8Linked to original sources
PubMed1970

Extraneural metastases in ependymoma of the cauda equina.

A case of ependymoma of the cauda equina, presumably originating from the filum terminale in a girl aged 17 at the onset of illness, eventually developed remote metastases in the lungs, pleura, and one para-aortic lymph node. This case is compared with three other previously reported examples. The unusual features in the present instance were (1) the total length of the clinical history, amounting to 29 years; (2) the development, six years after the removal of the original spinal tumour, of another ependymomatous mass in the fourth ventricle, interpreted as a rostral metastasis that seeded via the cerebrospinal fluid; and (3) the demonstration of anaplastic cytological changes at the primary site, interpreted as the result of irradiation. The salient aspects of this and the three other reported cases are briefly reviewed, and the pathway of distant dissemination, resulting from venous permeation at the primary site, is emphasized.

Adolescent↗
PubMedDate not supplied

Regulatory idiotopes, parallel sets and internal image of the antigen within the polyfructosan-A48 idiotypic network.

The study of the A48 idiotype anti-beta 2----6-polyfructosan immune response was used as a tool to investigate the various postulates of the immune network theory. The results of this study have shown: that only certain idiotopes, designated as regulatory idiotopes, play a role in idiotype-regulated immune responses; that some of the A48 idiotopes were expressed on a myeloma protein with unknown binding activity (MOPC173) and on MOPC167, a phosphorylcholine-binding myeloma protein; that one out of six monoclonal antiidiotypic antibodies tested carried the internal image of the antigen and could elicit an antibacterial levan immune response in mice treated at birth with bacterial levan or polyclonal anti-A48Id antibodies.

Animals↗