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Biomedical subjects

L J Milne

Publications and source records attributed to L J Milne.

At least 37 records · Page 2Linked to original sources
PubMed1982

Disseminated aspergillosis occurring in patients with respiratory, renal, and hepatic failure.

Respiratory, renal, and hepatic insufficiency developed in five patients who had been admitted to hospital for a variety of reasons. Although in four cases Aspergillus had been isolated from tracheal secretions before death, the significance of this finding was not fully appreciated, and in all five the diagnosis of aspergillosis was made at necropsy. Since treatment has to be started early if it is to be effective, patients with any combination of respiratory, renal, and hepatic failure should have their tracheal secretions examined daily. If Aspergillus is cultured, and hyphae are present in a fresh smear, and the patient has features of a generalised infection without an obvious site of infection, treatment for aspergillosis should be considered.

Acute Kidney Injury↗
PubMed1982

A clinical study of econazole cream in the treatment of fungal skin infections.

An open assessment of the efficacy of econazole nitrate (Pevaryl) cream in the treatment of 140 patients with proven dermatomycoses was conducted at five university health centres. Specimens were obtained from 129 patients at the end of treatment and 121 (93.8 per cent) showed no evidence of fungi. After a further month without treatment 108 patients reattended and, of these, 98 (90.9 per cent) remained clinically and mycologically free from infection. Trichophyton rubrum and Epidermophyton floccosum were the fungi most frequently isolated, and the distribution of species and areas of the body affected were similar for all five centres.

Dermatomycoses↗
PubMed1981

Prevalence of Yeast and fungi other than Candida albicans in the vagina of normal young women.

Yeasts and fungi other than Candida albicans were isolated from the vagina of 86 out of 1498 women (5.7 per cent) who attended a family planning clinic and they comprised 27.7 per cent of all fungal species obtained. These fungi were significantly more common in women aged 35 years and over and in those who used the diaphragm than in others. They were no more common in women with an abnormal vaginal discharge on examination than in others; and they were no more common in women with genitourinary symptoms than in women without.

Adolescent↗
PubMed1979

Vaginal microbial flora in normal young women.

Vaginal swabs were taken from 1498 women attending a family planning clinic. The flora was assessed in the absence of any information about the women to whom the swabs related. Yeasts and fungi were present in 311 women (21%) and were no more prevalent among "pill" users than others. Candida albicans was significantly associated with vulval itching and with a vaginal discharge described as heavier than normal or curdy on clinical examination, though these abnormalities were present in only a minority of women with the organism. Trichomonas vaginalis was found in 14 women (1%) and was associated with abnormalities of vaginal discharge in all but one. Gram-negative anaerobic bacilli were significantly more common in women with a troublesome vaginal discharge and those who used an intrauterine device than others. No associations were found between fungi other than C albicans or the other bacteria sought and either symptoms or clinical abnormalities of vaginal discharge.

Adolescent↗
PubMed1978

Mycetoma.

Explore the source record for details and available documents.

Actinomycetales↗
PubMed1976

Beclomethasone dipropionate aerosol and oropharyngeal candidiasis.

In a survey of 400 consecutive patients with chronic asthma treated with beclomethasone dipropionate aerosol (up to 400 mug/day) the prevalence of oropharyngeal thrush was 4-5%. The prevalence of this complication was not significantly related to sex, age, duration of treatment with beclomethasone or concurrent treatment with prednisolone. Yeasts were isolated from throat swabs in about 60% of all patients and in 48% of normal controls. Thus, although a diagnosis of oropharyngeal thrush was recorded only when the presence of characteristic lesions in the pharynx was associated with a positive culture, there was a large number of patients and controls without thrush who harboured yeasts in the throat. One in 3 patients with thrush complained of sore throat or hoarseness, but 1 in 4 patients without thrush had similar symptoms. These findings suggest that, although treatment with beclomethasone dipoprionate aerosol undoubtedly can cause oropharyngeal thrush, this condition is not an inevitable result of colonization of the oropharynx by yeasts, nor is it necessarily associated with symptoms.

Adolescent↗
PubMed1974

Beclomethasone dipropionate and oropharyngeal candidiasis.

A survey of 936 patients attending a respiratory diseases unit outpatient department was performed to assess the incidence of oropharyngeal candidiasis in patients inhaling beclomethasone dipropionate in daily doses of 400 mug or less. Throat swabs from 209 (41%) patients treated with beclomethasone were positive on culture for yeasts compared with positive swabs from 77 (27.2%) patients not receiving corticosteroid therapy either orally or by inhalation. Clinical oropharyngeal thrush, confirmed by culture, was detected in 28 (5.5%) patients inhaling beclomethasone, one (0.7%) patient receiving treatment with oral prednisolone, and two (0.7%) patients not being treated with corticosteroids.

Administration, Oral↗