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Biomedical subjects

L J Jensen

Publications and source records attributed to L J Jensen.

28 records · Page 2Linked to original sources
PubMed1985

Prophylactic vancomycin versus placebo in arterial prosthetic reconstructions.

Vascular reconstructive surgery with the placement of prosthetic material caudal to the diaphragm is occasionally associated with postoperative wound infection. These infections often lead to amputation and can be lethal. Only a few published reports contain information on the value of prophylactic antibiotic treatment with these operations, but its use is common throughout the world. To investigate this problem, a prospective, double blind, randomized study of vancomycin versus placebo in 128 vascular graft operations caudal to the diaphragm was conducted from June, 1982 to July, 1984. The difference in infection rate was significant (2 p = 0.0008) in favor of the vancomycin group. Fourteen wound infections (21.2%) were found in the placebo group, 3 of which (4.5%) were prosthesis infections. Among the 62 vancomycin-treated patients, one case of superficial wound infection (1.6%) and no cases of prosthesis infection were found. The most common pathogen was Staphylococcus aureus. The study has demonstrated that vancomycin, a narrow spectrum antibiotic, in an ultra-short regimen (one gram one hour before surgery and one gram 4 hours later) is an effective prophylactic agent against postoperative wound infection. Temporary and, in most cases, doses-related side effects were seen in 7.9% of the patients treated with vancomycin.

Arteries↗
PubMed1985

Prosthetic graft infections: a review of 720 arterial prosthetic reconstructions.

Six-hundred-and-three patients who underwent 720 vascular prosthetic graft operations caudal to the diaphragm were studied retrospectively. Wound complications appeared in 99 patients. Prophylactic antibiotics were not used. Serous secretion was found after 27 arterial graft procedures (3.8%), superficial wound infection after 41 (5.7%), and prosthetic graft infection after 31 (4.3%). Of the 31 patients with prosthetic graft infection, 10 recovered (32%). Four of these patients recovered after removal of the Staphylococcus aureus-infected prosthesis. Three received a replacement prosthesis with systemic antibiotic treatment and closed antibiotic irrigation, and one patient's prosthesis was replaced with an autologous vein graft with antibiotic treatment. Twelve patients (39%) underwent amputation and 9 died. The frequency of graft occlusion was greater when the prosthesis was infected with Staphylococcus aureus than with other microorganisms. The aggressive approach used in the 4 above-mentioned cases could be a treatment modality in prosthetic graft infection with Staphylococcus aureus, especially because of the high incidence of graft occlusion associated with these microorganisms.

Amputation, Surgical↗
PubMedDate not supplied

Three views of microbial genomes.

We describe here GenomeAtlases as a method for visualising three different aspects of complete microbial chromosomes: repeats, DNA structural characteristics, and base composition. We have applied this method to all publicly available genomes, and find a general strand preference of global repeats. The atlas for the Mycoplasma genitalium genome is presented as an example, and results from all three views are consistent with known characteristics of the genome.

Base Composition↗