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Biomedical subjects

L J Grota

Publications and source records attributed to L J Grota.

At least 73 records · Page 4Linked to original sources
PubMed1975

Effects of early experience and dexamethasone on adrenocortical reactivity.

This investigation tested the hypothesis that changes in circulating adrenocortical hormones mediate the long term effects of shocking infant rats. Dexamethasone administered through the mothers' milk was used to block adrenocortical responses to peripheral shock stimulation by the young. Control experiments indicated that the dexamethasone was present in the pups as early as 2 days after the mothers began drinking water containing dexamethasone. Shock reduced adrenocortical reactivity under conditions where the mother and the young were capable of an adrenocortical response to the shock, where either the mother or the young could have a response, and where neither the mother nor the young could have an adrenocortical response to this early stimulation. These data do not support the hypothesis that a pituitary-adrenocortical response of either the mother or the young mediates the effects of stimulation in infancy on subsequent adrenocortical reactivity.

Adrenal Cortex↗
PubMed1975

Localization of immunoreactive androgen in testicular tissue.

Immunohistochemical localization of androgen in the testes of both rat and squirrel monkey has been performed using an antiserum specific to testosterone and certain related androgens. The bound antibodies were visualized by coupling with antigammaglobulin labeled either with fluorescein isothiocyanate or with a horseradish peroxidase-diaminobenzidine technique. The highest concentration of androgen was found in the interstitial tissue but a significant amount was also present in the seminiferous tubules in the layer adjacent to the tubular wall. Very small amounts of androgen were localized in the tubular wall. This restricted localization in the tubules might indicate either de novo synthesis or active uptake of steroids intermediate in the biosynthesis of testosterone in the seminiferous tubules.

Animals↗
PubMed1972

Differential susceptibility of male and female mice to encephalomyocarditis virus: effects of castration, adrenalectomy, and the administration of sex hormones.

Male mice have been noted to be more susceptible to encephalomyocarditis (EMC) virus than female animals. Castration of male mice abolished this difference and resulted in enhanced resistance similar to that of female mice. This increase in resistance in castrated males could be eliminated by adrenalectomy. Adrenalectomy alone increased susceptibility in male mice but not in female mice. The administration of a long-acting preparation of testosterone markedly increased susceptibility both in castrated male and female mice, as well as in intact females. Testosterone also had a similar effect in immature mice of both sexes. On the other hand, estradiol, but not progesterone, increased susceptibility to EMC virus in castrated mice of both sexes. These data indicate that testicular, ovarian, and adrenal hormones may influence resistance to EMC virus in the mouse and may be critical determinants of the clinical outcome of infection with this virus.

Adrenal Glands↗