Search PubMed⌕ Search

Biomedical subjects

L J Grobler

Publications and source records attributed to L J Grobler.

At least 19 recordsLinked to original sources
PubMed2001

The pathomechanism of spondylolytic spondylolisthesis in immature primate lumbar spines in vitro and finite element assessments.

STUDY DESIGN: Immature Chacma baboon (Papio ursinus) spine specimens were used to determine load-displacement behavior as related to disc injury. This was accomplished through the application of A-P shear force until failure of FSUs with pars defects. Several finite element models (FEMs) of the FSU were developed to study the mechanism of slippage in immature baboon lumbar spines. OBJECTIVES: The purpose was to show that spondylolisthesis (olisthesis) always occurs through the growth plate using a model similar to immature human lumbar spines. Using FEMs, the roles of facet orientation, pars interarticularis thickness, and a weak growth-plate in producing slippage were examined. SUMMARY OF BACKGROUND DATA: Progression from spondylolysis (lysis) to olisthesis occurs, most often, during the adolescent growth spurt. The biomechanical literature dealing with the slippage mechanism in the immature lumbar spine does not provide a clear understanding and is sparse. METHODS: Several groups of FSUs were subjected to A-P shear force until failure. The results provided displacement at failure as a function of disc injury and flexion-extension fatigue. A bilateral pars defect was created in each specimen prior to application of A-P shear force using an MTS machine. Failure sites were assessed radiographically and histologically. A nonlinear 3-D FEM of the intact L4-L5 was created from CT scans. The model was modified to predict the effects of a pars fracture, a thin pars, a weak growth plate, and facet orientation on the shear load through the growth plate and stresses in the pars. RESULTS: Experimentally, failures always occurred through the growth-plate in the disc intact and disc-incised groups. In the intact FEM, the growth plate carried21% of the applied A-P shear force. The load increased when the facets were more sagittally oriented. The effect of thin pars and/or weaker growth plate was an increase in stresses in the pars. Changes in the load through the growth plate were minimal. CONCLUSIONS: The weakest link in immature baboon lumbar functional spinal units (FSUs) with lysis during an A-P shear load was the growth plate, between the cartilaginous and osseous end plates. Surgeons may assess this lesion on MRI views, thereby predicting the possible development and preventing progression of olisthesis. Finite element model results predict that more sagittally orientated facets and/or a pars fracture are prerequisites for olisthesis to occur.

Age Factors↗
PubMed1999

Stability analysis of an enhanced load sharing posterior fixation device and its equivalent conventional device in a calf spine model.

STUDY DESIGN: An in vitro test of calf spine lumbar segments to compare biomechanical stabilization of a rigid versus a dynamic posterior fixation device. OBJECTIVES: To compare flexibility of a dynamic pedicle screw fixation device with an equivalent rigid device. SUMMARY OF BACKGROUND DATA: Dynamic pedicle screw device studies are not as prevalent in the literature as studies of rigid devices. These devices contain the potential to enhance load sharing and optimize fusion potential while maintaining stability similar to that of rigid systems. METHODS: Load-displacement tests were performed on intact and stabilized calf spines for the dynamic and rigid devices. Stability across a destabilized L3-L4 segment was restored by insertion of either a 6 mm x 40 mm dynamic or rigid pedicle screw fixation device across the L2-L4 segment. The screws then were removed, 7 mm x 45 mm pedicle screws of the opposite type were inserted, and the construct then was re-tested. Axial pull-out tests were performed to assess the likely effects of pedicle screw replacement on the load-displacement data. RESULTS: Results indicated a 65% reduction in motion in flexion-extension and a 90% reduction in lateral bending across the destabilized level for both devices, compared with intact spine values. Reduction in axial rotation motion was much smaller than in other modes. Axial pull-out tests showed no weakening of the bone-screw interface. CONCLUSIONS: Both devices provided significant stability of similar magnitudes in flexion, extension, and lateral bending. In axial rotation, the devices only could restore stability to levels similar to those in an intact spine. The dynamic device offers a design that may enhance load sharing without sacrificing construct stability.

Animals↗
PubMed1999

Predictors of surgical outcome in degenerative lumbar spinal stenosis.

STUDY DESIGN: A prospective, observational study. OBJECTIVES: To identify outcome predictors of surgery for degenerative lumbar spinal stenosis. SUMMARY OF BACKGROUND DATA: Degenerative lumbar spinal stenosis is the most frequent indication for spine surgery in the elderly. More than 25% of surgical patients have a poor outcome, yet little is known about factors that predict the outcome of surgery. METHODS: Surgery was performed on 199 patients with degenerative lumbar spinal stenosis, and they were observed for 2 years after surgery in four referral centers. Surgery consisted of decompressive laminectomy with or without arthrodesis. Outcomes included validated measures of symptom severity, walking capacity, and satisfaction with the results of surgery. Potential predictors of outcome included sociodemographic factors and physical examination, as well as radiographic, psychological, social, and clinical history variables. RESULTS: The proportion of patients with severe pain decreased from 81% before surgery to 31% by 2 years afterward. The most powerful preoperation predictor of greater walking capacity, milder symptoms, and greater satisfaction was the patient's report of good or excellent health before surgery. Low cardiovascular comorbidity also predicted a favorable outcome. CONCLUSIONS: Patient's assessments of their own health and comorbidity are the most cogent outcome predictors of surgery for spinal stenosis.

Aged↗
PubMed1998

The pathomechanism of isthmic lumbar spondylolisthesis. A biomechanical study in immature calf spines.

STUDY DESIGN: Anterior shearing force was applied to immature calf lumbar functional spinal units until failure. OBJECTIVES: To clarify the mechanism of slippage in immature calf lumbar spines with pars defects as a first step to understand the mechanism of spondylolisthesis in pediatric human lumbar spines. SUMMARY OF BACKGROUND DATA: Progression from lysis to olisthesis occurs during the adolescent growth spurt. However, the mechanism of slippage in the immature lumbar spine has not yet been understood clearly. METHODS: Bilateral pars defects were created at the rostral vertebra. The specimens then were assigned to one of the two groups: functional spinal units with intact disc (n = 5) and with disc dissected (n = 5). In the former group, the disc was left intact, whereas in the disc dissected group, the anterior longitudinal ligament and 75% of the anterior-to-posterior depth of the disc were incised along the mid-disc plane. Using a uniaxial MTS machine (MTS System, Minneapolis, MN), anteroposterior shearing force was applied to each specimen. Failure load and displacement at failure were calculated from the load--displacement curve. Failure sites also were assessed radiographically and histologically. RESULTS: The five functional spinal units in the intact disc group failed at 973.8 +/- 78.1 N, whereas specimens in the disc dissected group failed at 986.4 +/- 124.2 N. The data showed no significant differences between the two groups. All the specimens showed displacement through the growth plates on radiographs. Histologically, failure was observed to occur between the superior growth plate and osseous endplate of caudal vertebra, indicating that this site is the weakest link. CONCLUSIONS: The results suggest that in the pediatric immature lumbar spine with pars defects, slippage may occur between the growth plate and osseous endplate.

Animals↗
PubMed1998

Reliability of axial landmarks for pedicle screw placement in the lower lumbar spine.

STUDY DESIGN: Measurements were made on transverse-plan, computed tomography scans from three different patient groups. OBJECTIVE: To describe the correlation between two previously described pedicle screw entry points to the pedicle axis and the predicted frequency of pedicle breakthrough from the use of a 6.5-mm screw placed parallel to the pedicle axis. SUMMARY OF BACKGROUND DATA: Fluoroscopic assistance improves the accuracy of pedicle screw placement. Whether this is a result of improved accuracy of the starting point or correct directional guidance is unclear. No morphologic studies have been done to assess the accuracy of previously described entry points. METHODS: Computerized digitizing and mathematic superimposition of the images from computed tomography scans of the low lumbar spine were used to quantify facet and pedicle anatomy and the correlation between two previously described entry points and the pedicle axis. RESULTS: The two previously described entry points are significantly medial to the pedicle axis. They are most medial at the L5 pedicle in patients with L4 degenerative spondylolisthesis. CONCLUSIONS: The two previously described entry points for pedicle screws in the low lumbar spine that were studied here are not reliable and tend to direct screw placement medial to the pedicle axis enough to lead to a substantial frequency of pedicle breakthrough for screws parallel to this axis. Surgeons implanting screws should take this tendency into account and use alternative methods to obtain accurate entry to the pedicle.

Adolescent↗
PubMed1998

Neurocentral synchondrosis fracture in immature spines associated with pedicle screw type fixation devices.

The purpose of this study is to clarify the weak point in immature lumbar vertebrae associated with pedicle screw instrumentation. Ten immature thoracic and lumbar vertebrae were collected from calf spines. After installation of 6- and 7-mm-diameter pedicle screws into the pedicles of each specimen, pullout force was applied to the screw using the uniaxial MTS system until failure. Tightening torque during installation was measured. From the load-displacement curve, failure load was calculated and failure site was confirmed by radiographs. Inner pedicle diameters were measured after the pullout test, and percent fills of the pedicle screw were calculated. Mean tightening torque was 1.4 or 2.1 (Nm), mean failure load was 852.5 or 1,015.0 (N), and mean percent fill was 81.4 or 93.5% for 6- or 7-mm screws, respectively. Tightening torque and percent fill in 7-mm screws were significantly (p < 0.01) greater than that in 6-mm screws; however, failure load showed no significant difference (p = 0.10) between the two screw groups. Failure by screw pullout occurred at the screw-bone interface or through the neurocentral synchondrosis (NS). NS fractures were observed in 20% of 6-mm screws, 60% of 7-mm screws, and 40% overall, whereas interface failures occurred in 80% of 6-mm screws, 40% of 7-mm screws, and 60% overall. In NS fracture group, tightening torque (p < 0.05) and percent fill (p < 0.01) were significantly greater than in the interface failure group. The results led us to conclude that the mechanism of the NS fracture is unclear. However, NS fracture could be one of the conceivable complications associated with pedicle screw fixation in the immature spine.

Animals↗
PubMed1998

Back and leg pain in older adults. Presentation, diagnosis, and treatment.

Back and leg pain in the older population are of diagnostic and therapeutic importance for both primary and tertiary care providers. Careful assessment of the clinical presentation, potential differential diagnosis, and treatment options are essential to optimize outcome results. Well-proven conservative treatment modalities always should be the first regimen after confirmatory diagnostic studies. The available surgical treatment options must be used judiciously for the correct indications in suitable patients. A team approach in taking care of this group of patients is both essential and rewarding.

Aged↗
PubMed1997

Lumbar laminectomy alone or with instrumented or noninstrumented arthrodesis in degenerative lumbar spinal stenosis. Patient selection, costs, and surgical outcomes.

DESIGN: A prospective, multicenter observational study. OBJECTIVES: 1) Identify correlates of the decision to perform arthrodesis in patients undergoing laminectomy for lumbar spinal stenosis. 2) Compare symptoms, walking capacity, and satisfaction 6 and 24 months after laminectomy alone and laminectomy with noninstrumented and with instrumented arthrodesis. BACKGROUND DATA: Few prospective studies have compared outcomes of laminectomy alone or laminectomy with noninstrumented or with instrumented arthrodesis in patients with degenerative lumbar spinal stenosis. There is uncertainty regarding the optimal use of arthrodesis and instrumentation. METHODS: Two hundred seventy--two patients undergoing--surgery for degenerative lumbar stenosis by eight surgeons at four centers were included in the study cohort. Of these, 37 had noninstrumented and 41 had instrumented arthrodesis. Logistic regression identified factors associated with arthrodesis. The principal outcomes-health status, walking capacity, back and leg pain, and satisfaction with surgery-were assessed 6 and 24 months postoperatively with univariate and multivariate techniques. Outcomes also were assessed in a restricted cohort of patients with at least 5 mm spondylolisthesis and/or 15 degrees scoliosis. Hospital costs were obtained from a computerized hospital cost accounting system. RESULTS: The major predictor of the decision to perform arthrodesis was the individual surgeon (P = 0.0001). Noninstrumented arthrodesis was associated with superior relief of low back pain at 6 months (P = 0.004) and 24 months (P = 0.01). This difference persisted in multivariate analyses, with borderline statistical significance. There were no significant differences in the other outcomes across treatment groups. Mean hospital costs of laminectomy alone and noninstrumented and instrumented arthrodesis were $12,615, $18,495, and $25,914, respectively (P = 0.0001). CONCLUSION: Findings were limited by the small number of participating surgeons, modest sample size that produced P values of borderline significance, and nonrandomized design. With these caveats in mind, the authors conclude: (1) The individual surgeon was a more important correlate of the decision to perform arthrodesis than clinical variables such as spondylolisthesis. (2) Noninstrumented arthrodesis resulted in superior relief of back pain after 6 and 24 months. (3) Instrumented arthrodesis was the most costly option. These results highlight the need for randomized controlled trials and cost effectiveness analyses of lumbar arthrodesis and instrumentation in patients with degenerative lumbar spinal stenosis.

Aged↗
PubMed1997

Comparing Mersilene* tape and stainless steel wire as sublaminar spinal fixation in the Chagma baboon (Papio ursinus).

The development of segmental instrumentation has been a major advancement in the treatment of spinal problems, but the use of sublaminar stainless steel wire (SSW) has not been without untoward effects. This study reports a comparison of Mersilene* tape (MT) and stainless steel wire (SSW) used for sublaminar fixation in the Chagma baboon (Papio Ursinus). A similar comparative study has not been reported, although the local effects of sublaminar SSW in the spinal canal have previously been described. The adult Chagma baboon was selected as the experimental animal due to its partial upright posture and spinal anatomy, similar to that of the human. Six levels of the thoracolumbar spine were instrumented with custom designed Harrington hooks and regular one-quarter inch threaded rods used as a distraction system. The four intervening laminae were fixed to the rods using doubled-over, eighteen gauge sublaminar SSW in six cases and five millimeter MT in six cases. Computed axial tomography used to measure the AP diameter of the bony spinal canal revealed the AP space occupied by the SSW and MT to be 32 percent and 14.8 percent respectively. In the MT group, the overlying dura mater was found to be totally intact and revealed no signs of abnormal tissue response. A well-formed connective tissue membrane consisting of dense connective tissue surrounded the MT and was found to consist of more mature fibers than that found in the SSW group. The dura-implant interface was examined histologically and a distinct membrane was identified between the dura and the superficial aspect of the MT's, as well as intervening between the two MT's. Following removal of the MT, in contrast to the SSW, it was apparent that the underlying dura was not injured, most probably due to the soft consistency of the Mersilene* tape and the well-formed overlying membrane. On clinical grounds the fixation in both groups was adequate but the MT group formed a well-circumscribed membrane that made removal of the MT easier and potentially safer. The AP space occupied by the spinal implant was also found to be less with MT as opposed to SSW.

Animals↗
PubMed1995

Clinical correlates of patient satisfaction after laminectomy for degenerative lumbar spinal stenosis.

STUDY DESIGN: Prospective multicenter observational study of the outcome of surgery for degenerative lumbar spinal stenosis. OBJECTIVES: To identify correlates of patient satisfaction with the results of surgery. SUMMARY OF BACKGROUND DATA: Little published information exists on correlates of patient satisfaction after surgery for spinal stenosis. METHODS: Preoperative and 6-month follow-up data for 194 patients were analyzed. Associations between preoperative variables and satisfaction with the results of surgery were examined in univariate and multivariate models. RESULTS: In multiple linear regression models that adjusted for the effects of age, gender, individual surgeon, number of interspaces decompressed, whether a fusion was performed, depression score, and overall level of pain, the predominance of back (as opposed to leg) pain, greater comorbidity, and worse preoperative functional status were associated with lower patient satisfaction. The regression model explained just 15% of the variance in patient satisfaction. CONCLUSIONS: Patients bothered predominantly by back pain preoperatively and those with greater medical comorbidity and functional disability are significantly less satisfied with the results of surgery for degenerative lumbar spinal stenosis.

Aged↗
PubMed1994

Multidirectional stability of the Graf system.

STUDY DESIGN: To assess the biomechanical influences of the Graf fixation system on the spine, motion segments were tested. In normal spines, destabilized and restabilized with the Graf system conditions, the range of motion and flexibilities were found under various loading conditions. OBJECTIVES: These results should explain how the Graf Fixation system affects the biomechanical response of a motion segment. METHODS: Motion segments (L2-3) and (L4-5) were subjected to these loading conditions: compressive loading, flexion-extension, lateral bending, and axial rotation moments. During the loading, the main and coupled motions were measured, and flexibilities were computed. The position of the balance point in axial loading was also determined. The motion segments were tested under three conditions: intact, destabilized, and restabilized. The destabilization consisted of a bilateral total laminectomy (pedicle-to-pedicle). Restabilization was affected with the Graf stabilization system, consisting of polyester bands between pedicle screw implants. RESULTS: The total laminectomy significantly changed the balance point location by moving it forward. The restabilized motion segment had a balance point more similar to normal conditions. The mean compressive compliance was significantly less after application of the Graf system compared with destabilization. The range of motion for flexion-extension and axial rotation was significantly reduced for the main motion with the Graf system. For lateral bending, the main and coupled rotations were affected significantly, with lateral bending and flexion-extension motion reduced and axial rotation increased after restabilization. Restabilization decreased the flexibility of the destabilized motion segment for all of the moments. CONCLUSIONS: The Graf fixation system reduced the range of motion and the flexibility values in some loading conditions. These results only assess the immediate stabilization characteristics of this implant system in cadaveric material. Further research should address the fatigue characteristics.

Biomechanical Phenomena↗
PubMed1994

L4-5 isthmic spondylolisthesis. A biomechanical analysis comparing stability in L4-5 and L5-S1 isthmic spondylolisthesis.

The authors have previously reported that the L4-5 isthmic spondylolisthesis lesion often progresses more than the L5-S1 lesion in adult patients. This biomechanical study compares the in vitro stability of the L4-5 isthmic spondylolisthesis lesion compared with the L5-S1 isthmic lesion. The authors also analyzed the role of the L5 iliolumbar ligament as a contributing factor to stability. Six fresh frozen human cadaveric specimens (L4 to the sacrum including the iliolumbar ligamentous complex) were tested by applying 10 Nm flexion-extension moments. Sagittal plane motion was measured with the specimens intact and after sequential transection of the pars interarticulares at L4 and L5 and finally with the iliolumbar ligaments cut at L5-S1. L4-5 and L5-S1 both showed significant increases in rotation with the pars defect compared with normal (L4-5 = +2.0, L5-S1 = +3.2 degrees). Decreased translation of L5-S1 occurred with pars defect at this level. There were no significant differences at the L5-S1 level after sectioning of the iliolumbar ligament. Calculating the percentage difference from normal, L4-5 with a pars defect exhibited significantly greater relative motion compared with L5-S1 with the same defect; 12% more rotation, 33% more shear, and 43% more axial translation. The iliolumbar ligament did not appear to contribute to these differences because there was no significant change in the L5-S1 kinematics after its transection. These results support the hypothesis that L4-5 pars defects are more unstable than L5-S1 lesions. The iliolumbar ligament could not be implicated as the major contributing factor in these differences.

Biomechanical Phenomena↗
PubMed1994

Osteophyte formation in the vertebral column: a review of the etiologic factors--Part II.

Osteophyte formation in the vertebral column is a well documented phenomenon that is poorly understood. The most commonly identified etiologic factors are degeneration and altered mechanics of the spine, either of which in turn have been considered to be a result of the natural aging process or the pathogenesis of spinal disease. In Part I [Contemporary Orthopaedics, 29(1): 31-37, 1994], the process of osteophyte formation was reviewed. In Part II, the sequential and consequential changes from the finely interwoven events of aging, degeneration, mechanical instability, and disease are described.

Adolescent↗
PubMed1993

Decompression for degenerative spondylolisthesis and spinal stenosis at L4-5. The effects on facet joint morphology.

Anatomic variations exist in the facet joint orientation, shape, and size at L4-5. This morphology is further modified by degenerative changes in spinal stenosis and degenerative spondylolisthesis. This study explored the morphologic alteration of "pedicle-to-pedicle" decompression on the facet joints in normal patients, spinal stenosis patients, and degenerative spondylolisthesis patients. Using computerized digitization, computed tomographic scan images of the facet joint at L4-5 and the medial border of the pedicle at L5 were superimposed. The facet joint orientation, coronal dimension, percentage, and absolute reduction in coronal dimension after pedicle-to-pedicle decompression, and residual coronal dimension after decompression at L4-5 were measured for the three groups. There is a significantly reduced coronal dimension of the facet joint in degenerative spondylolisthesis patients compared with spinal stenosis and normal patients (P < 0.01). The average reduction of the facet joint coronal dimension is 34% (SD 30%) in degenerative spondylolisthesis, and 36% (SD 25%) in spinal stenosis. The smaller preoperative coronal dimension in degenerative spondylolisthesis leads to a significantly reduced residual coronal dimension in degenerative spondylolisthesis compared with normal patients (5.9 mm [SD 4.3 mm] vs. 9.3 mm [SD 3.5 mm]), respectively. Wide variations in facet joint reduction and residual facet joint coronal dimension exist. The significantly reduced coronal dimension after decompression in degenerative spondylolisthesis may be correlated to a trend to further anterior displacement if it is treated with decompression alone. Case-specific assessment of residual facet joint morphology after decompression in both spinal stenosis and degenerative spondylolisthesis patients should be integrated into decisions about fusion for stability at the L4-5 level.

Aged↗
PubMed1993

Postoperative spondylolisthesis at L4-5. The role of facet joint morphology.

Thirty-three patients underwent decompression without fusion at the L4-5 level for spinal stenosis or degenerative spondylolisthesis. Using preoperative and 1-year postoperative lateral lumbar spine radiographs, the incidence of postoperative spondylolisthesis of greater than 5% was found to be 58%. Computed tomographic scans were used to analyze the presurgical facet joint morphology and facet joint-pedicle spatial relationship. This allowed calculation of the facet joint orientation for each side; the coronal dimension of each facet joint; the amount of the facet joint coronal dimension removed if a decompression was performed up to the medial border of the L5 pedicle (facet joint reduction); and the residual coronal dimension of facet joint after such a decompression (residual facet joint). The lateral radiographs were analyzed for presurgical disc height and the presence of traction spurs or spondylophytes. A well-maintained disc height was associated with an increase slip (7.47%) compared with those cases with a narrow or complete loss of disc space before surgery (4.84% P < 0.1 trend). Presence of spondylophytes was associated with a reduced tendency to slip. When spondylophytes were controlled for there was a significant relationship between slip of greater than 10% and sagittal facet joint orientation. Although there was a lesser residual facet joint after decompression in the group that slipped these values were not statistically significant. This study suggests that the development of postoperative spondylolisthesis is related to facet joint orientation and dimensions, rather than the absolute amount of joint removed. The stabilizing effects of reduced disc height and spondylophytes were confirmed.

Aged↗