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Biomedical subjects

L J Friedman

Publications and source records attributed to L J Friedman.

10 recordsLinked to original sources
PubMed1991

Three cases of paraphilias responsive to fluoxetine treatment.

Three cases are presented in which fluoxetine was employed in the apparently successful treatment of paraphilia, a disorder which has been difficult to treat pharmacologically. Therapeutic benefit may have been related to the efficacy of fluoxetine in the treatment of obsessive compulsive disorders or to direct effects on sexual activity, or both.

Adult↗
PubMed1985

Cone antagonism along visual pathways of red/green dichromats.

We have measured thresholds for bichromatic test-mixtures in red/green dichromats. Our results provide strong evidence for cone-antagonistic coding along the dichromats' detecting pathways. The threshold behavior of the isolated dichromatic pathways is consistent with that predicted by Opponent Colors Theory. We compare these threshold data with the dichromats' judgments of "blue/yellow" hue equilibria, which we obtained in supra-threshold color-cancellation experiments. The results are consistent with the hypothesis that both sets of data are mediated by the same dichromatic cone antagonistic pathway.

Adaptation, Ocular↗
PubMed1984

Temporal integration of the pi 1/pi 3 pathway in normal and dichromatic vision.

Stiles' pi 1 and pi 3 mechanisms are thought to reflect adaptation events at two sites in a single pathway, the first site controlled by the short-wavelength cones alone, the second site controlled by opposing signals from these cones vs the other cone classes. We examined this pathway's temporal integration under conditions that yield the full gamut of possible adaptation states at the two sites. Critical duration of the pi 1/pi 3 pathway was always about 200 msec. In addition, we examined the pi 1 and pi 3 mechanisms of dichromatic vision. Our results suggest that protanopic and deuteranopic vision are characterized by a pi 1/pi 3 pathway similar to that in normal color vision.

Color Perception↗