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Biomedical subjects

L J Findley

Publications and source records attributed to L J Findley.

136 records · Page 8Linked to original sources
PubMed1977

Nomifensine in parkinsonism.

1. The effect of nomifensine was compared with that of placebo in a double-blind crossover study in patients with parkinsonism. 2. Of the 29 patients who entered the study, three were previously untreated and 26 continued their L-DOPA or other antiparkinsonian therapy, or both, during the trial. 3. Clinical assessments were made at fortnightly intervals throughout the study. 4. The most noticeable improvement during active treatment--namely, tremor, facial expression and finger flexion were moderate in extent. 5. When placebo was substituted for active drug a significant deterioration of physical signs and functional disability occurred (P less than 0.001). 6. Elderly patients fared less well than younger patients, and the most common adverse effect was involuntary movements.

Aged↗
PubMed1976

Nomifensine in parkinsonism.

Nomifensine, a tetrahydroisoquinolone antidepressant which facilitates dopaminergic and noradrenergic transmission, was studied in 28 Parkinsonism patients most of whom were also receiving conventional medications. Double-blind evaluations revealed a moderate therapeutic action at a mean dose level of 150 mg daily. Adverse reactions were encountered, similar to those identical by levodopa.

Aged↗
PubMed1975

Interactions of levodopa with inhibitors of monoamine oxidase and L-aromatic amino acid decarboxylase.

Drug interactions between levodopa, tranylcypromine, and carbidopa have been studied in 4 patients with idiopathic parkinsonism. Pressor responses were induced by a combination of levodopa and tranylcypromine. These hypertensive reactions were inhibited by carbidopa, indicating that they are mediated at the periphery. Very small doses of levodopa induced an improvement in parkinsonism when patients were concomitantly taking carbidopa and tranylcypromine, but adverse reactions were prominent.

Adult↗
PubMedDate not supplied

Effect of doxapram on obstructive sleep apnea.

To determine whether treatment with a respiratory stimulant, doxapram hydrochloride, would improve obstructive sleep apnea, we administered the drug to four patients with this disease. Subjects were given a bolus of doxapram, 0.5 mg X kg-1 lean body mass, followed by a 1 mg X min-1 infusion throughout the night on one night and placebo another night. Doxapram produced improvement in the average oxyhemoglobin desaturation during apneic and hypopneic episodes and decreased average apnea length, but did not change the average number of oxyhemoglobin desaturations per hour of sleep or sleep efficiency. We conclude that doxapram, when administered at levels known to increase ventilatory drive, does not decrease the number of disordered breathing events during sleep but does cause termination of these events at higher levels of oxyhemoglobin saturation.

Adult↗
PubMedDate not supplied

Carotid sinus hypersensitivity in patients referred with possible epilepsy.

Four patients with recurrent transient loss of consciousness, all of whom had previously undergone extensive non-invasive cardiological investigations, were referred for neurological opinion. All were found to exhibit a resting bradycardia and a cardioinhibitory response to carotid sinus stimulation. All were referred for cardiological opinion but only two patients were considered by their respective cardiologists to warrant pacemaker implantation. Those who did not receive a pacemaker continue to suffer from their symptoms. The clinical management of these patients highlights an apparent divergence of opinion amongst cardiologists on the treatment of carotid sinus hypersensitivity and emphasises that, unless the ECG and blood pressure responses to carotid sinus stimulation are observed in patients with histories of unexplained episodes of altered consciousness, carotid sinus hypersensitivity will be missed as a possible cause of symptoms. The presence of unexplained bradycardia may suggest carotid sinus hypersensitivity.

Adult↗