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L J Faling

Publications and source records attributed to L J Faling.

49 records · Page 3Linked to original sources

Differentiation of pleural and pulmonary lesions using computed tomography.

We report an analysis of computed tomography (CT) of the thorax in 75 patients with combinations of pleural and parenchymal disease or complex pleural shadows. These patients were among more than 300 with pulmonary disease examined by this method. Twenty-eight percent of the 75 scans within this group were classified as high value, contributing information which was not available from other clinical or roentgenographic data, and which directly altered the management, diagnosis, or prognosis of these patients. Forty percent of the scans were classified as of intermediate value, contributing to better understanding of the case but with no major influence on patient management or prognosis. Thirty-two percent of the scans added no additional information to the chest roentgenograms. Thirty-seven percent of the 46 scans done specifically to differentiate pleural from parenchymal disease were classified as of high value, but only 14% of the scans in patients with pleural fluid loculations or pleural masses were placed in this category. We conclude that thoracic CT provided information not otherwise available in one third of the patients with complex combined pleural and parenchymal disease examined in our series.

Adult↗

Quantitative tracheal bacteriologic and cytologic studies in patients with long-term tracheostomies.

Quantitative aerobic and anaerobic cultures were performed on 28 tracheal aspirates from 16 clinically stable patients with tracheostomies. There were an average of six isolates per specimen, and the mean bacterial concentration was 106.9 organisms per milliliter. The numerically dominant bacteria were aerobic and facultative gramnegative bacilli. Anaerobic bacteria were recovered from just nine specimens (32 percent); and, when present, these organisms were found in relatively low concentrations. Repeat cultures obtained 30 to 60 days later from the same patients showed substantial changes in flora, but the numerically dominant species tended to persist. Cultures of saliva and throat swabs collected at the time of tracheal aspiration showed that there was little correlation between the bacteriologic findings from the upper and lower airways. Cytologic studies indicated a mean of 12,900 cells per cubic millimeter of tracheal aspirate, with polymorphonuclear leukocytes being the predominant forms. No correlation could be found between the concentrations of polymorphonuclear leukocytes and quantitative bacterial counts. These studies indicate that tracheal aspirates from patients with stable tracheostomies harbor a complex, predominantly aerobic flora which is subject to change and bears little relationship to the flora of the adjacent upper airways. Our results also suggest that neither quantitative bacterial cultures nor cytologic analysis of these specimens would be helpful in distinguishing colonization from overt infection requiring antibiotic treatment.

Aged↗

Observations on the medical efficacy of computed tomography of the chest and abdomen.

In a retrospective study of 687 computed tomographic (CT) examinations of the chest and abdomen performed over a 1 year period, 16% of the examinations produced information not otherwise available which altered patient diagnosis, prognosis, or therapy. Sixteen thoracotomies and 18 laparotomies were avoided as a result of information available only from CT examinations. CT was of particular value in the evaluation of mediastinal masses, in the assessment of suspected or proven lung cancer, and in the evaluation of pleural and extrapleural masses. It was of notable clinical value in evaluating patients with intraabdominal abscesses, pancreatic disease, staging of malignancies for radiation therapy and surgery, and excluding the presence of suspected masses.

Abdomen↗

A prospective randomized trial of combination vindesine and cisplatin versus single-agent vindesine in advanced non-small cell lung cancer.

Antineoplastic agents, used alone or in combination, are capable of achieving objective remissions in advanced nonsmall cell lung cancer. Response rates have been modest, however, and responses are generally not durable. Furthermore, the toxicity of some regimens has been substantial, creating a narrow therapeutic ratio and a questionable impact on survival. The addition of cisplatin (DDP) to cyclophosphamide and doxorubicin (Adriamycin) resulted in major response rates that were superior to those obtained with cyclophosphamide or doxorubicin used alone or in combination. Vindesine (DVA) was evaluated in several phase II trials that demonstrated reproducible limited antitumor activity in nonsmall cell lung cancer. Gralla et al combined DVA with DDP in regimens of varying DDP dosage and noted a response rate of about 43%.

Antineoplastic Combined Chemotherapy Protocols↗

The diagnosis of unsuspected esophageal perforation by computed tomography.

The successful management of esophageal perforation requires prompt diagnosis and surgical intervention. The hazards of delayed recognition of esophageal perforation have been recently emphasized. A case of unsuspected esophageal perforation detected by computerized tomography of the chest (CT) is described and illustrated. CT is an effective technique for displaying mediastinal and complex pleural-parenchymal abnormalities and often provides information which is of diagnostic value.

Carcinoma, Squamous Cell↗