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Biomedical subjects

L J Cohen

Publications and source records attributed to L J Cohen.

At least 55 records · Page 3Linked to original sources

Suicide and schizophrenia: data from a prospective community treatment study.

This article reports the analysis of prospectively gathered data on eight young adults who committed suicide during an ongoing longitudinal study of long-term treatment of schizophrenia in the community. Young adult men with an early onset of psychiatric illness were identified as a high-risk subgroup. At the time of admission to the study, the subjects who eventually committed suicide reported significantly more distress and tended to be less satisfied with their lives than the other subjects. Specifically, baseline measures of self-reported subjective distress were consistently predictive of later suicide, whereas interviewer-rated measures and postbaseline assessments were not.

Adolescent↗

A modern parable.

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Acute Kidney Injury↗

Mother's helper.

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Euthanasia↗

Benign lymphocytic angiitis and granulomatosis: a case report with evidence of an autoimmune etiology.

Benign lymphocytic angiitis and granulomatosis (BLAG) is characterized by dense benign-appearing infiltrates of mature lymphocytes, plasma cells, and histiocytes within the pulmonary parenchyma and vasculature. The disorder typically is restricted to the lungs and has a good prognosis. The authors report a patient with BLAG and involvement of lung, kidney, and prostate. This is the first report of prominent systemic distribution in this disease. Another unique feature of this case was the presence of serum antinuclear antibodies and evidence of immune complex deposition in both lung and kidney, suggesting an underlying autoimmune disorder. An association of this entity with lymphomatoid granulomatosis (LG) has been suggested, and the prominent genitourinary disease in this patient may be indicative of a transitional stage leading to LG. An autoimmune state may be the underlying stimulus for the development of BLAG and LG.

Antibodies, Antinuclear↗

Spontaneous aorto-caval fistula Report of 2 cases.

Spontaneous aorto-caval fistulas are uncommon. Two cases are presented, and the angiographic findings are discussed. The diagnosis may be confirmed by simultaneous opacification of an abdominal aortic aneurysm and the inferior vena cava.

Aged↗

An unusual movement disorder associated with neuroleptic treatment: tardive dyskinesia?

This case report describes a chronically psychotic man presenting signs of a movement disorder exacerbated by neuroleptic treatment and repeatedly diagnosed as tardive dyskinesia. However, this movement disorder differed from classical tardive dyskinesia both in the nature of specific symptoms and in their relationship to neuroleptic treatment. Closer examination revealed evidence of neurolgical disorder preceding the earliest neuroleptic treatment. Although the nature of this disorder remains unclear, serious doubt exists whether it properly deserved a diagnosis of tardive dyskinesia, which opened the way for medicolegal dispute. The numerous ramifications of tardive dyskinesia speak for restrictive use of this diagnosis and for clear diagnostic criteria.

Adult↗

The unstated problem in a psychological testing referral.

There is a manifest and a latent content to many psychological testing refereals. Although a diagnostic problem is usually the stated reason for the referral, the unstated and more basic reason frequently has to do with problems the therapist is encountering in attempting to deal with a difficult treatment situation. The testing psychologist who responds at the manifest level alone may not help and at times may even be a hindrance.

Adolescent↗

Sonography of hepatic amebic abscesses.

The spectrum of gray scale ultrasonographic patterns are described as seen in 17 hepatic amebic abscesses in eight patients. Of the abscesses 16 had a lower gray tone than the adjacent normal liver. In patients with multiple lesions, generally there was a reciprocal relation between abscess size and echogenicity and a direct relation between internal echogenicity and through transmission. The results in these eight patients suggest a role for ultrasound both in the diagnosis and treatment of hepatic amebic abscesses.

Adult↗

Development of an animal model for Mycoplasma-related reproductive failure.

Pregnant hamsters and mice were injected ip with various doses of Mycoplasma hominis, M fermentans, and M arthritidis, all of which may have a potential role in human or animal reproductive failure. Inoculations were made near the completion of each trimester, and the products of conception were removed by hysterectomy 24 hr before anticipated delivery. Resorptions and birth defects were tabulated. Preliminary data on 1869 fetuses indicate that BALB mice merit further evaluation as a possible model for mycoplasma-related reproductive failure.

Animals↗

Bibliotherapy. The therapeutic use of books for women.

Bibliotherapy is the use of literature to help heal. It can be an effective intervention for nurse-midwives to use with clients. Presented is a discussion of how to do bibliotherapy and an annotated bibliography of resources.

Bibliotherapy↗

Comorbid personality impairment in body dysmorphic disorder.

Personality impairment was evaluated in 17 body dysmorphic disorder (BDD) patients undergoing a treatment study of clomipramine versus desipramine. Semistructured interviews were administered using both categorical (Structured Clinical Interview for DSM [SCID II]) and dimensional (Dimensional Assessment of Personality Impairment [DAPI]) methods. Personality measures were also correlated with a range of clinical variables (severity of BDD and depressive symptoms, age, duration of illness, and response to treatment). A secondary aim of the study was to provide preliminary validation for the DAPI. Consistent with previous studies, BDD patients showed considerable personality pathology. By SCID II, patients met criteria for a mean of 2.53 personality disorder diagnoses; 87% of patients met criteria for at least 1 diagnosis and 53% for more than 1. Cluster C diagnoses were the most common. Mean scores for the DAPI were 2.63 (3 = mild impairment) to 6.41 (7 = severe impairment), averaging 5.26 (5 = moderate). With regard to the DAPI, the results provided preliminary evidence of good reliability and validity. Moreover, both personality measures were highly intercorrelated. Although SCID II diagnoses correlated with baseline depression (Hamilton Rating Scale for Depression [HRSD]) scores, there were few other significant correlations between personality and other clinical variables. Of note, however, treatment responders demonstrated less personality impairment than nonresponders. The finding that personality measures were highly intercorrelated but, on the whole, not well correlated with other clinical measures supports the distinct and dissociable nature of personality phenomena in BDD. Despite the small sample size, these results suggest that personality impairment appears to be significant factor in BDD and may even play a role in treatment response.

Adult↗