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Biomedical subjects

L Iversen

Publications and source records attributed to L Iversen.

At least 91 records · Page 5Linked to original sources
PubMed1991

Reduced neutrophil LTB4 release in atopic dermatitis patients despite normal fatty acid composition.

Propositions about an abnormal fatty acid metabolism in atopic dermatitis patients prompted us to compare the phospholipid fatty acid composition and LTB4 release of neutrophils from 15 atopic dermatitis patients, as well as the adipose tissue triglyceride fatty acid composition, to that of 15 healthy controls matched by age, gender, and smoking habits. We found no differences in the tissue fatty acid composition between the two groups. The release of leukotriene B4 from Ca-ionophore-stimulated neutrophils in patients was on the average only 42% (p less than 0.001) of that measured in the control group, despite the very similar arachidonic acid contents of these cells. Our study does not support the assumption of an abnormal fatty acid desaturation in atopic dermatitis patients. Rather, the capacity to release and/or convert arachidonic acid into leukotrienes in neutrophils appears to be affected by this disease.

Adipose Tissue↗
PubMed1989

Hospital admissions before and after shipyard closure.

To determine the effect of job loss on health an investigation was made of admissions to hospitals in 887 men five years before and three years after the closure of a Danish shipyard. The control group comprised 441 men from another shipyard. The information on hospital admissions was obtained from the Danish national register of patients. The relative risk of admission in the control group dropped significantly in terms of the number of men admitted from the study group from 1.29 four to five years before closure to 0.74 in the three years after closure. This was especially true of admissions due to accidents (1.33 to 0.46) and diseases of the digestive system (4.53 to 1.03). For diseases of the circulatory system, particularly cardiovascular diseases, the relative risk increased from 0.8 to 1.60, and from 1.0 to 2.6 respectively. These changes in risk of illness after redundancy are probably a consequence of a change from the effects of a high risk work environment to the effects of psychosocial stresses such as job insecurity and unemployment.

Accidents↗
PubMed1988

Participation in a follow up study of health among unemployed and employed people after a company closedown: drop outs and selection bias.

This article presents an analysis of study loss in a three year longitudinal study of 1816 employees at two Danish shipyards, one of which closed just before the start of the study. The aim of the study was to elucidate the health consequences of a company closedown and the subsequent job loss. The study population responded to an identical questionnaire in 1983, 1984 and 1985. The participation rate in 1983 was 73%. The percentage of drop outs in 1984 and 1985 was 15-20% of the total numbers responding in the first year. We examined this study loss in relation to the characteristics of the respondents, using the first round of data collection as a baseline. In a multivariate analysis, age and seniority at the shipyard were the only variables that were significantly associated with non-participation in 1984 and 1985. It is concluded that the drop outs did not appear to introduce a serious risk of selection bias in 1984 and 1985. A comparison between drop outs and late respondents in 1984 and 1985 did not support the supposition that information about late respondents can be extrapolated to drop outs.

Adolescent↗
PubMed1987

Unemployment and mortality in Denmark, 1970-80.

Relative mortality in the period 1970-80 was studied among Danish men and women who were unemployed and employed on the day of the 1970 census. The study population consisted of the total labour force in the age range 20-64 on 9 November 1970--that is, about 2 million employed and 22,000 unemployed people. Relative mortality was analysed by a multiplicative hazard regression model (as a natural extension of the standardised mortality ratio) and a multiplicative regression model with extra-Poisson variation. A significantly increased death rate (40-50%) was found among the unemployed after adjusting for occupation, housing category, geographical region, and marital state. Analysis of five main causes of death showed increased mortality from all causes, but especially from suicide or accidents. In areas where the local unemployment rate was comparatively high the relative mortality among the unemployed was lower. The increased mortality among the unemployed was interpreted as a consequence of health related selection as well as increased susceptibility associated with the psychosocial stress of unemployment.

Adult↗
PubMed1986

Alcohol consumption among laid-off workers before and after closure of a Danish ship-yard: a 2-year follow-up study.

The daily consumption of alcohol in a study of a population of Danish ship-yard workers laid off in relation to unexpected closure, was measured in 1976 (7 months before being laid off) and in 1978 (1 1/2 year after being laid off). The study population (N = 88) consisted mostly of skilled male workers. Data in 1976 and 1978 were collected in exactly the same manner. The main findings were that the unemployed workers were more likely to reduce their alcohol consumption than the reemployed workers in the same population-controlling for age. The study brings no evidence which could support the popular belief of a causal relation between unemployed and use of alcohol.

Alcohol Drinking↗
PubMed1981

Inhibition of [3H]GABA binding to postsynaptic receptors in human cerebellar synaptic membranes by carboxyl and amino derivatives of GABA.

Fifty synthetic analogues of GABA were tested for their ability ot interact with GABA receptors, using [3H]GABA binding to human cerebellar membranes as an in vitro model. The most active compounds were found to be aliphatic and heterocyclic aminosulphonic acids. Compounds with highly substituted nitrogen atoms were only weakly active unless a long alkyl chain, which can interact with the postsynaptic membrane, was present. It was concluded that a pyramidal nitrogen atom is favoured fro binding of GABA analogues to human cerebellar membranes.

Cerebellum↗