Search PubMed⌕ Search

Biomedical subjects

L I Shevchenko

Publications and source records attributed to L I Shevchenko.

25 records · Page 2Linked to original sources
PubMedDate not supplied

[Status of glycolysis in newborns with hypoxia].

An incriase has been shown in the blood content of lactate, NADH2, pyruvate, activity of lactatedehydrogenase in hypoxic newborn infants, which fact is believed to have a positive character. Under conditions of deficient supply of tissues with oxygen activization of glycolysis is of compensatory character. The results obtained should be regarded as a positive factor aimed to make up for the fund of NADH2, a potential energy product securing ATP synthesis through aerobic mechanism.

Apgar Score↗
PubMedDate not supplied

[Effect of new hemocorrectors on heart mitochondrial oxidation in hemorrhagic shock].

In experimental model of hemorrhagic shock, the influence of new hemocorrectors, succinasole and sucksivil (1,4-naphtoquinone) on rabbit myocardial mitochondrial oxidation was studied. Both substances improved function of myocardial mitochondria. Administration of new hemocorrectors increased duration of life of animals subjected to hemorrhagic shock, improved hemodynamics, metabolism, normalized myocaidla mitochondrial functions and increased positive effect of shock therapy.

Animals↗
PubMedDate not supplied

[Determination of fibrinogen concentration in blood plasma by the sulfite precipitation method].

Two methods using thrombine and sulfite were compared for estimation of fibrinogen concentration in blood plasma. Both methods produced the same results in estimation of fibrinogen in donor blood plasma. If blood plasma contained high amount of products of fibrinogen and/or fibrin degradation, the efficiency of thrombin method was decreased; on the other hand, final concentration of sulfite did not precipitate fragment D of fibrinogen from human blood plasma. Presence of heparin did not influence on the sulfite method but the polysaccharide might interfere in the thrombin method. Some experiments require to use both these methods for evaluation of fibrinogen in blood plasma.

Fibrinogen↗
PubMedDate not supplied

[Determination of fibrin and fibrinogen split products by their anticoagulant activity].

A new diagnostic method to determine fibrinogen and fibrin splitting products is based on the fact that high-molecular fragments acting as specific inhibitors of fibrin self-assembly compose these products. Fibrinogen and fibrin splitting products are detected and determined quantitatively by prolongation of coagulation time in the test with the standard monomeric fibrin. The number of units of anticoagulating activity in the studied urine are the results of the determinations. Sensitivity of the method if necessary may be increased by adding of a certain amount of the fibrinogen and fibrin splitting products to the test that makes a favourable background for the action of the products. The method is rather sensitive, reliable and simple. It may be used in ordinary clinical laboratories. The method proved to be quite satisfactory when testing renal diseases at the clinic. It is of great significance for early detection of the transplanted kidney rejection. The new method is compared with the known immunological method which consist in determination of the inhibitory effect of the fibrinogen and fibrin splitting products on agglutination of erythrocytes of specific antibodies; the erythrocytes being subjected to "tanning" and "loading" with fibrinogen. A satisfactory correlation is found between the results of two methods.

Adult↗