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Biomedical subjects

L I Rose

Publications and source records attributed to L I Rose.

At least 55 records · Page 3Linked to original sources
PubMed1981

Androgen abnormalities in acne vulgaris.

Thirty-six women with acne vulgaris who consulted gynecologist with complaints of hirsutism, infertility, menorrhagia, or oligomenorrhea were evaluated for an androgen abnormality with assays for testosterone (T), androstenedione (A), and dehydro-epi-androsterone (DHEA). Forty-eight percent of the DHEA measurements were elevated and 61% of the patients had elevation of one or more of the three measurements. The frequency of abnormal androgen levels remained relatively constant regardless of the severity of the presenting signs and symptoms. This study calls attention to the high frequency of an androgen abnormality in acne patients who also have evidence of hirsutism, menstrual irregularity, and/or infertility. Consideration should be given to assaying DHEA, T, and A levels in an effort to discover those patients who have a systemic endocrine disorder, of which acne manifests as a sign.

Acne Vulgaris↗
PubMed1981

Mesocricetus auratus: a new animal model for studying diabetes mellitus in pregnancy.

To document the feasibility of using Syrian hamsters to study diabetic pregnancies, mature virgin hamsters (Mesocricetus auratus) were given a single injection of streptozotocin, inseminated the third succeeding ovulation following the injection, and the fetuses examined 1 day prior to delivery (Day 15 post-conception). A dose-response to streptozotocin was observed with an optimum dose of 56 mg/kg body weight. A significantly elevated serum glucose (459 +/- 34 mg/dl versus 160 +/- 15 mg/dl; p less than 0.01) was observed concomitantly with a decrease in maternal weight change 4.89 +/- 9.2 versus 32.5 +/- 5.8 g; p less than 0.05). Fetuses from treated dams were significantly smaller (24.3 +/- 0.9 mm versus 27.4 +/- 0.9 mm; p less than 0.05) and lighter, and 47% of all treated animals demonstrated fetal death and resorption. Conception rates were, however, unaffected. Therefore, diabetes was induced well in advance of conception in this species, eliminating the diabetogenic drug as a factor in the fetal effects while maintaining the benefits of large numbers for evaluation.

Animals↗
PubMed1980

The effect of long-distance running on plasma immunoreactive glucagon levels.

Twelve highly conditioned long-distance runners were studied to determine the effects of marathon (42 km) and 10,000 m running on plasma immunoreactive glucagon (IRG), serum immunoreactive insulin (IRI), and serum glucose (G) levels. Blood samples were drawn just prior to and immediately upon completion of the run. Marathon running resulted in no significant change in G, IRI, or IRG levels. After running 10,000 m, plasma IRG levels did not change significantly, while IRI and G increased significantly. In evaluating the pooled data from both runs, a significant inverse correlation was observed between delta G and delta IRG. This relationship between delta G and delta IRG suggests that glucagon plays a role in maintaining normal blood glucose levels during strenuous exercise.

Adult↗
PubMed1979

delta 4-3-Ketosteroid 5 alpha-oxidoreductase in human uterine leiomyoma.

Homogenates of human endometrial, myometrial, and leiomyoma tissues were incubated with (1,2,6,7-3H)-testosterone, and 3H-dihydrotestosterone was subsequently identified, indicating the presence of the enzyme delta 4-3-Ketosteroid 5 alpha-oxidoreductase. The enzyme activity of leiomyoma was higher than that of endometrial and myometrial tissue, while endometrial activity was higher than myometrial activity. The results raise the possibility that 5 alpha-reduced androgens may play a role in the pathophysiology of uterine leiomyoma.

3-Oxo-5-alpha-Steroid 4-Dehydrogenase↗
PubMed1979

Gonadotropin profiles in fed and fasted obese women.

Five obese women were studied before and at the end of a prolonged fast to determine the effect on luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and on the response to luteinizing hormone--releasing factor (LRF). Although baseline serum LH values declined from a mean value of 9.1 to 6.5 m.I.U. per milliliter measured at the end of the fast, these changes in mean serum level were not statistically significant. However, the integrated LH secretion did decline when measured at the end of the fasts (p less than 0.05). FSH secretion did not change. LRF-stimulated LH and FSH values showed augmented stimulation at the end of the fast. Pulsatile gonadotropin secretion patterns remained normal. Prolonged fasting appears to alter the baseline LH secretion and the pituitary response to exogenous LRF.

Adult↗
PubMed1979

The partial adrenocortical hydroxylase deficiency syndrome in infertile women.

Eighteen infertile women desiring conception were selected for additional diagnostic studies on the basis of clinical evidence of hyperandrogenism characterized by acne and/or facial hirsutism. These 18 patients underwent stimulation tests with adrenocorticotropic hormone which demonstrated the presence of partial adrenocortical hydroxylase deficiences. All patients were then placed on glucocorticoid suppression therapy. Ten patients conceived and, of these, six required no therapy other than prednisone. Four conceived using a combination of prednisone and clomiphene therapy. Of othe eight patients who did not conceive, seven had other significant infertility factors. Therefore, of the patients without other significant fertility factors, 91% conceived. This study demonstrates that partial adrenocortical enzyme defects play a significant role in some women with clinical evidence of hyperandrogenism, and, in such women, either glococorticoid therapy alone or in combination with clomiphene is indicated.

Adolescent↗
PubMed1979

Therapy of adrenocortical hydroxylase deficiencies in acne vulgaris.

Twenty women with acne vulgaris who presented to a gynecologist's office with the complaints of hirsutism, infertility, menorrhagia, or oligomenorrhea were subjected to a 24-hour cosyntropin (ACTH) infusion to detect partial 11- or 21-adrenocortical hydroxylase deficiencies. All patients demonstrated enzymatic defects and were placed on prednisone therapy. The six patients with moderate acne either showed improvement of their acne or conceived. Of the 14 patients with mild acne, seven showed improvement of their acne or conceived; whereas, the remainder showed no improvement. Patients with acne and gynecologic signs and symptoms should be evaluated for the presence of 11- or 21-adrenocortical hydroxylase deficiencies.

Acne Vulgaris↗
PubMed1979

Gonadotropin, estradiol, and testosterone profiles in homosexual men.

The authors evaluated the gonadotropin-testosterone-estradiol profiles of four homosexual men and four heterosexual men by a multiple-sampling technique. Although there was extensive overlap between the two groups, the homosexual subjects had higher estradiol levels than the heterosexuals (70.3 +/- 19.8 versus 56.8 +/- 10.7 pg/ml) and lower FSH values (5.1 +/- 1.0 versus 13.2 +/- 3.4 mIU/ml). Testosterone and luteinizing hormone levels were comparable in the two groups. These observations suggest that there may be subtle differences in gonadotropin and estradiol secretion in homosexual subjects that can be detected only by repeated sampling.

Adult↗
PubMed1978

Panhypopituitarism resulting from Hodgkin's disease of the nasopharynx.

Nasopharyngeal involvement by Hodgkin's Disease is rare and may result in deafness, headaches, nasal obstructions and other symptoms. Compression of the pituitary gland with resultant panhypopituitarism has not been reported in nasopharyngeal Hodgkin's Disease. This paper documents a patient in whom Hodgkin's Disease of the nasopharynx eroded the bony sella turcica and compressed the pituitary gland causing anterior pituitary insufficiency. The patient presented with a skull x-ray and history compatible with a pituitary neoplasm. The diagnosis was established only by surgical exploration.

Bone Diseases↗
PubMed1978

The effect of E. coli L-asparaginase on oral glucose tolerance and insulin release in man.

To study the effect of E. Coli L-asparaginase on glucose tolerance and insulin release, 6 patients with neoplastic disease were subjected to 3 hour oral glucose tolerance tests with simultaneous measurement of serum immunoreactive insulin (IRI) levels before and following the intravenous administration of 5000 I. U. L-asparaginase/day for 4 days. Five of the patients exhibited a significant deterioration in glucose tolerance; however, no change was noted in their fasting glucose and IRI levels. The deterioration in glucose tolerance was associated with a decrease in the amount of insulin secreted in the first 30 minutes after the oral glucose load. The total amount of insulin released during the 3 hour test remained unchanged. These studies suggest that L-asparaginase can cause a deterioration of glucose tolerance without accompanying fasting hyperglycaemia. This may be due, in part, to a decrease in glucose-induced insulin release during the first thirty minutes following oral glucose.

Adult↗
PubMed1978

Reduction of testosterone to 5 alpha-dihydrotestosterone by human and rat uterine tissues.

Incubations of adult rat uterine tissue and human endometrial and myometrial homogenates with [1,2,6,7-3H]testosterone resulted in the formation of 5 alpha-[3H]dihydrotestosterone. The rat uterine homogenates showed higher activity than the minced tissue. The activity in human tissue was found to be less than rat tissue on a per unit weight basis. The human endometrium has been found to possess significantly higher activity than myometrium. These results support the hypothesis that androgens may exert their effect on uterus via 5 alpha-reduced metabolites.

3-Oxo-5-alpha-Steroid 4-Dehydrogenase↗
PubMed1977

Insulin-dependent diabetes mellitus. Sudden onset following hypophysectomy in an acromegalic patient.

A euglycemic woman with acromegaly contracted conspicuous hyperglycemia two hours following transphenoidal hypophysectomy. Insulin therapy was initiated and has by necessity been continued. The development in the immediate postoperative period of blood glucose levels ranging from 300 to 500 mg/dl was totally unexpected, as the levels on the preoperative oral glucose tolerance test were normal. No explanation for this sudden development of hyperglycemia is apparent. Therefore, frequent monitoring of the blood glucose level is necessary in all acromegalic patients following hypophysectomy, even if they are euglycemic prior to surgery.

Acromegaly↗