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Biomedical subjects

L Huyghens

Publications and source records attributed to L Huyghens.

43 records · Page 3Linked to original sources
PubMed1985

Acute and chronic intoxication with carbromal preparations.

An important number of acute intoxications can be ascribed to the abuse of, until now, non-prescription carbromal preparations. Prolonged use of these drugs also leads to chronic intoxication with bromide accumulation. The clinical features and treatment of three suicidal Obral overdoses and of two patients presenting with bromism are presented. Laboratory findings, from admission to recovery, consist of qualitative TLC and quantitative HPLC drug assays in body fluids and the determination in plasma of the two competing ions chloride and bromide. The high frequency of acute intoxications and carbromal induced bromism stresses the need to bring these preparations under prescription.

Acute Disease↗
PubMed1985

Eisenmenger's syndrome and pregnancy.

The Eisenmenger's syndrome (E.S.) was redefined by Wood (1958) as pulmonary hypertension with reversed or bidirectional shunt at the aortopulmonary, ventricular or atrial level. This eponym is applicable to 12 different congenital cardiac lesions. Pregnancy in patients with E.S. is a particularly hazardous situation in respect to the prohibitive features of maternal and perinatal mortality (Gleicher et al., 1979; Jones & Howitt, 1965; Neilson et al., 1971).

Adult↗
PubMed1983

Cost evaluation of infections in intensive care.

The study deals with one aspect of cost benefit analysis of infection control, namely the measurement of extra costs incured by patients who acquired nosocomial infections (NI) in intensive care units (ICU). The consequences of NI are expressed in terms of length of stay, extra drug and antibiotic costs, extra sterile supply used and mortality. Infected patients stayed at the ICU twice as long as non - infected patients, the mean cost of antibiotics prescribed was four times higher, the mean value of other drugs and infusion fluids was approximately 1 1/2 times higher. Three methods for measuring cost are compared: the physician's assessment method, comparison of infected patients with all non - infected patients and matched control analysis.

Cost-Benefit Analysis↗
PubMedDate not supplied

Recurrent pulmonary embolism: importance, diagnosis, management and prevention.

Pulmonary emboli, even small, cause irreparable lung damage. Recurrent pulmonary emboli further increase the amount of non functional lung tissue and may result in incapacitating respiratory disease or death. It is therefore mandatory that the disease be correctly diagnosed and adequately treated. As prevention is better than cure, every patient presenting with clinical signs of deep venous thrombosis (DVT) should be correctly explored. The site and size of thrombosis must be visualized preferably with contrast venography with imaging of the veins of the limbs, iliac veins and vena cava. Risk factors such as obesity, immobilization etc. must be taken into account. Underlying disease such as heart disease and venous insufficiency must be treated. Malignancy must be looked for as in a recent series of patients with primary DVT which were studied, 15% presented with an up till then unknown malignant disease. In patients presenting with recurrent DVT this percentage rose to 20%. When a patient presents with DVT of the femoro-iliac vena cava axis, aggressive treatment must be adopted. Fibrinolysis or if this is contra-indicated, thrombectomy will be used. A vena cava filter may be necessary and longterm anticoagulation is mandatory. The same rationale is applicable in cases of pulmonary embolus whether it is a primary event or a recurrence.

Angiography↗