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Biomedical subjects

L Hunter

Publications and source records attributed to L Hunter.

89 records · Page 5Linked to original sources
PubMed1975

Effect of albumin on serum digoxin radioimmunoassays.

The use of certain commerically available radioimmunoassay kits for measurement of digoxin results in errors in the determined digoxin concentration of patients when these kits are used according to manufacturers' directions. One factor that is, in part, responsible for these errors is a difference between standards and samples with respect to albumin concentration. Three of the four kits investigated showed a significant inverse relationship between the albumin concentration in the sample and the binding of radiolabeled digoxin by its antibody when the albumin concentration was varied over an extended range. It is apparent, however, that differences in albumin concentration do not completely explain the observed variations in the assay values.

Binding Sites, Antibody↗
PubMed1974

Carcinoembryonic antigen (CEA) monitoring in the management of radiotherapeutic patients.

We have measures serial carcinoembryonic antigen (CEA) titers in 92 patients, randomly selected from the patient population of a Radiotherapeutic Clinic, to correlate with clinical and follow-up evaluation. 57 out of 92 patients had positive CEA levels (2.5 ng/ml) or 62 percent of proven cancer patients. In this series, 67 percent (63/92) showed positive correlation between the curves of CEA levels and the clinical evaluation of disease activity. A simple computerized program was designed with the data collection directed to identifying parameters and trends of different groups. Breast CA showed 89 percent correlation; lung carcinoma showed 80 percent large bowel 75 percent, and other organs showed less. This assay is a prototype study of human response to therapy in relation to tumor antigen and host response, as measured by a nonspecific tumor associated antigen.

Breast Neoplasms↗
PubMedDate not supplied

Development of a single component of a performance evaluation protocol. The faculty impression score.

The issues of uniformity, consistency, and fairness in the measurement of behavioral skills constitute the ongoing debate of clinical evaluation. Evaluation tools, particularly those that propose to measure observed phenomena, have been judged to be limited in validity or reliability and are, therefore, more subjective than is desirable. Nurse-midwifery educators are challenged to identify or develop clinical and professional performance instruments, and to achieve interfaculty reliability in their application. In addition, nurse-midwifery educational programs that make use of nonsalaried and/or off-site preceptors to contribute to student education must accept the dual challenges of development of clinical teaching skills and also the consistent application of the program's evaluation instruments and methods. The development of the "faculty impression score" as a supplemental, but critical, element within a behaviorally anchored, criterion-referenced evaluation protocol is presented.

Attitude of Health Personnel↗
PubMedDate not supplied

New path for health-care leadership: clinical systems management. CLMA Clinical Systems Management Task Force.

This article sets forth a concept and an action plan to support the educational needs for the clinical systems manager. This article describes the roles, competencies, and tasks of the clinical systems manager and defines specific intermediate and long-term steps. Clinical systems management is umbrella terminology used to describe an array of related jobs including, but not necessarily limited to, multidepartmental or interdisciplinary management, regional or health system-wide laboratory management, and traditional laboratory management. In general, clinical systems management recognizes the emergence of new jobs, with the primary responsibility of leading the integration of clinical services within health-care systems.

Data Collection↗
PubMedDate not supplied

The preparticipation physical examination for athletics: a critical review of current recommendations.

The preparticipation physical examination (PPE) has become the standard of care for the millions of high school students in the United States as they prepare for athletic participation. These assessments are intended to identify medical conditions that may affect safe and effective participation in organized sports. The PPE has become an integral aspect of the athletic and sports medicine system during the last three decades. Over time, the PPE has been revised, largely based upon the recommendations of large medical organizations. Several primary and secondary goals have been presented to be accomplished through the PPE. One particular goal of these assessments is to identify individuals with underlying cardiovascular disease, a significant cause of acute sudden cardiac death in high school and college athletes. While current research continues to demonstrate that the PPE has no effect on the overall morbidity and mortality rates in athletes, other objectives may be fulfilled by these examinations. In order to improve the ability of these examinations in fulfilling their primary objectives, instruments that have better results in preventing the injuries and deaths associated with athletic participation should be developed and investigate.

Adolescent↗
PubMedDate not supplied

Household context and youth smoking behaviour: prevalence, frequency and tar yield.

Labour Force Smoking Survey data were used to examine the impact of household environment on the smoking behaviour of youth and young adults. Three indicators of older adult smoking behaviour were used to classify the smoking environment of households. The indicators were smoking prevalence, the mean number of cigarettes smoked per day, and the mean tar yield of cigarettes. Within households, the probability that a young person smokes, how much they smoke, and the type of cigarette they smoke is closely associated with the smoking behaviour of older adults in the household. Household smoking patterns contribute to the overall exposure of family members to the hazards of cigarette smoking and may influence the outcome of smoking cessation programs. Smoking cessation and prevention programs should consider the potential effect of family and household environments.

Adolescent↗
PubMedDate not supplied

Cryptosporidia-positive rates of avian necropsy accessions determined by examination of auramine O-stained fecal smears.

Fecal smears from 112 avian necropsy accessions representing 431 birds were stained with auramine O and examined for Cryptosporidium oocysts by fluorescence microscopy. Stained Cryptosporidium oocysts fluoresced bright yellow-green and were easily differentiated from extraneous material by their uniform small size (approx. 5 micron) and morphology. The rates of cryptosporidia-positive accessions were 27.3% (9/33) of broilers, 10% (3/30) of broiler breeders, and 5.9% (1/17) of layers. Further analyses of available data for various risk factors that may have influenced rates of cryptosporidia-positive samples in broilers, broiler breeders, and layers failed to show significant relationships. However, it was apparent that positive samples were clustered within accessions and not scattered throughout the population sampled. This survey also resulted in the first reported identification of Cryptosporidium oocysts from a budgerigar, macaw, and tundra swan.

Aniline Compounds↗