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Biomedical subjects

L Hudson

Publications and source records attributed to L Hudson.

117 records · Page 7Linked to original sources
PubMedDate not supplied

Screening for Chlamydia trachomatis at a university health service.

Chlamydia trachomatis is the most common sexually transmitted infection in the United States. The aim of this study was to determine the prevalence of Chlamydia in college family planning patients and to identify diagnostic indicators associated with Chlamydia. A thorough history and physical examination was performed, including culture for gonorrhea, cancer (papanicolaou test), and Chlamydia trachomatis. Chlamydia occurred in 12.6% of 419 subjects. The lack of signs and symptoms and the possibility of inaccurate historical data limit the clinical predictability of chlamydial infections. Routine screening of college women is recommended.

Adolescent↗
PubMedDate not supplied

The computed tomographic enhancement pattern of the normal canine pituitary gland.

Dynamic computed tomography (CT) of the pituitary gland was performed on four healthy male dogs of similar size, weight and age. The pituitary gland region was first identified on lateral scout and transverse non-contrast images. After localization, water soluble iodinated contrast medium was administered intravenously as a bolus at a dose of 1 ml/lb using a pressure injector at an injection rate of 10 ml/sec and a total of 40 post contrast images of the pitutary gland were acquired. No images were made after 400 seconds. The same pituitary region was imaged in each slice. The slice thickness was 1.5 mm, with a two second scan time and an eight second delay between images (resulting in images every ten seconds). The contrast medium injection and initial image were acquired simultaneously, resulting in a non-contrast enhanced initial image. At the completion of the CT scan, a region of interest (ROI) was drawn around the pituitary gland and time density data were obtained. The mean pituitary Hounsfield number was plotted as a function of time. A bi-exponential least squares model was used to derive the best fitting line through the data. The mean relative peak increase in pituitary Hounsfield Units (HU) was 65.9% +/- 2.1%. After the initial increase there was a decrease in pituitary Hounsfield number with a half-time of 16.1 seconds, followed by a slower phase with a half-time of 16.5 minutes. The mean pituitary gland HU value during the period of gradual opacity decline was 35.0% +/- 4.4% above that of the pre-contrast image. Establishing the enhancement pattern in the canine pituitary gland is the precursor to the clinical application of dynamic CT of the pituitary gland to diagnose pituitary microadenomas and/or small macroadenomas before they become exceptionally large.

Animals↗
PubMedDate not supplied

Aberrant crypt foci in the colonic mucosa of rats treated with a genotoxic and nongenotoxic colon carcinogen.

Aberrant crypt foci (ACFs) are putative preneoplastic lesions in the colonic mucosa identified by examining methylene blue-stained whole mounts of colon. ACFs have been previously described in rats treated with genotoxic colon carcinogens. This study determined whether or not a nongenotoxic colon carcinogen could induce ACFs and compared the morphology of these ACFs with those induced by a genotoxic colon carcinogen. Six-wk-old Fischer-344 rats were administered dextran sulfate (DSS, nongenotoxin) in the drinking water or azoxymethane (AOM, genotoxin) by single subcutaneous injection. Rats were sacrificed at 9 and 14 wk after study initiation. Colons were fixed and stained with methylene blue, and the mucosal surface of transilluminated whole mounts was examined with a microscope. The number of ACFs and number of crypts per focus (multiplicity) were recorded. Representative ACFs were processed into glycol methacrylate for hexosaminidase enzyme histochemistry and sections of the remaining colon containing ACFs were embedded in paraffin for morphologic evaluation. In whole mounts, ACFs from AOM- and DSS-treated rats had elongated slit-to-oval-shaped lumens surrounded by a thickened and intensely stained epithelium. DSS-induced aberrant crypts differed from those induced by AOM in that they were frequently larger, tended not to form discrete foci circumscribed by normal crypts, and were located adjacent to ulcers. Total ACFs and large foci (4 or more crypts/focus) were significantly more numerous in AOM-treated rats at both time points. Histologically, DSS-induced ACFs had segmental to diffuse loss of hexosaminidase activity, mucin depletion to increased prominence of goblet cells, and marked distortion of crypt architecture. AOM-induced ACFs had diffuse loss of hexosaminidase activity, variable depletion of mucin, and less distortion of crypt architecture. Variable degrees of epithelial dysplasia were seen in ACFs with both carcinogens, but dysplasia was more severe in DSS-induced ACFs. Colonic mucosal neoplasms were induced by both carcinogens. In subchronic studies, the ACF assay may be a useful method to improve the identification and characterization of xenobiotic-induced changes in colonic mucosal crypts.

Animals↗
PubMedDate not supplied

A can-do diploma.

Explore the source record for details and available documents.

Child Day Care Centers↗
PubMedDate not supplied

The Tavistock study of young doctors: report of the pilot phase.

A consultant psychotherapist and an academic psychologist have talked in detail to SHOs about the satisfactions and dissatisfactions of the junior doctor's working life. Sometimes unexpected, the findings point to issues of serious concern.

Burnout, Professional↗