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Biomedical subjects

L Hellgren

Publications and source records attributed to L Hellgren.

At least 73 records · Page 4Linked to original sources
PubMed1976

Betamethasone-I7, 2I-dipropionate ointment: an effective topical preparation in lichen ruber planus.

A clinical evaluation was carried out in 19 patients with lichen ruber planus to assess the effectiveness of 0.05% betamethasone-17,21-dipropionate ointment in the treatment of patients whose lesions had developed resistance to prolonged treatment with 0.1% betamethasone-17-valerate ointment. The new steroid ointment was substituted for the previous preparation and applied at the same frequency, once or twice daily, for 2 to 3 weeks. The results at the end of the betamethasone-17,21-dipropionate period were classified as better in 14 (73.7%) and equal in the remaining 5 patients.

Administration, Topical↗
PubMed1976

Lichen ruber planus in occupational groups in total populations.

Distributed on 66 occupational groups (and 170 individual occupations) the prevalence of lichen ruber planus within the groups was determined by examining nearly every person in the total populations of 39,418 persons in five different areas in Sweden. The prevalence of l.r.p. in the total population was 0.3 per cent for males and 0.1 per cent for females. When l.r.p. prevalences were compared between different occupational groups, disturbing influences from age differences between the groups were eliminated by the standard population method. The indices calculated by aid of computer were used for direct ranking of the occupational groups from those with the highest to those with the lowest prevalences. In 33 of the 66 occupational groups (and in 129 of 170 individual occupations) no l.r.p. was found. In 24 male and 6 female occupational groups an overaverage high prevalence of l.r.p. was found. In two occupational branches, i.e. agriculture and forestry work (male agricultural workers, farmers, gardeners, garden workers and forest workers) and engineering and building metal work (steel-workers, plate-workers, machine and engine repairers, machine and engine mechanics, engineering workers, plumbers, metal workers) an overaverage high prevalence of l.r.p. was found in nearly all occupational groups. The results indicate that l.r.p. is more prevalent in occupational groups, in which the work dirties the skin (with i.e. soil, oil, cement dust), while in occupational groups with "clean work" the disease was less prevalent. However, there were exceptions. 67.7% of the males, 55.5% of the females had their debute lesions on the lower legs; in 21% of the males and 22.2% of the females the l.r.p. lesions debuted on the wrists. These are areas liable to exposure for different chemical substances and trauma.

Dermatitis, Occupational↗
PubMed1976

Induction of generalized pustular psoriasis by topical use of betamethasone-dipropionate ointment in psoriasis.

Three patients with chronic discoid psoriasis are described as having a generalized pustular eruption provoked by the topical use of betamethasone-dipropionate ointment (0.05%) over extensive skin areas for two or three weeks. All the lesions were nearly healed when the rash erupted. It is suggested that the potent topical steroid was absorbed through the damaged psoriatic skin, resulting in a systemic effect and a generalized pustular psoriasis (GPP). It was estimated that the patients absorbed at least 1.5 mg betamethasone per day during the application period.(i.e. 3 tablets of CelestonaR 0.5 mg). Just as steroids systemically are contraindicated in chronic discoid psoriasis by the risk of GPP, potent topical steroids must be avoided over large psoriatic skin areas.

Aged↗
PubMed1976

Studies on fatty acids in pus of psoriasis pustulosa palmo-plantaris.

Thin-layer chromatography was used to find out if there were any quantitative differences in fatty acid content in pus from the palmar pustules in ten patients with psoriasis pustulosa palmo-plantaris (PPP) before and after long-term tetracycline therapy. No significant differences were found, indicating that it was not possible to correlate the good therapeutic effect of antibiotics reported in PPP with a decrease in the fatty acid content of pus from the pustles. However, the series was small and investigations are now in progress to establish whether small differences of significance can be demonstrated in a larger series. By combined gas chromatography and mass spectrometry the fatty acids of pus in patients with psoriasis pustulosa palmo-plantaris were analysed. Stearic and palmitic acids were found to be predominant.

Chromatography, Gas↗
PubMed1975

Infrared spectroscopy for tracing of topically applied ointment vehicles and active substances on healthy skin.

Infrared spectroscopy was used to trace active substances and ointment vehicles applied on the skin. Vaseline and lanoline could be traced after 8 hrs but not olive oil. From the active substances, ethyl-4-amino-benzoate (5 per cent), clioquinol (5 per cent), parabenes (15 per cent), 5,7-dichlor-8-hydroxy-2-methyl-chinolin (5 per cent), balsam of Peru (25 per cent) and pyroleum pini (12 per cent) could be traced 1 hr after application but had disappeared after 8 hrs. Ethylenediamine (1 per cent), chlorcresol (1 per cent), pyroleum lithantracis (5 per cent), were not traceable after 1 hr, and curiously neither neomycine sulphate in spite of its high concentration (20 per cent). The reaction of the skin surface lipids, after application of different substances, was deduced from the spectra. Clioquinol and pyroleum lithantracis seem to give rise to hydrolysis of the triglycerides, the free fatty acids being clearly identifiable. It is felt that infrared spectroscopy can be used as an effective method to trace different substances such as potent allergens on healthy or diseased skin.

Balsams↗
PubMed1975

Comparison of allergenicity of a perfume in animals (guinea pig maximization test) and in humans (usage test).

Using the Guinea Pig Maximization Test, the sensitization rate of a perfume was shown to be 10 per cent, which means a mild allergenicity rate. A usage sensitization trial was performed with the same perfume included in a soap, on 300 persons for 2-3 months. Seventy-five of these, all house-wives, were randomly selected and tested epicutaneously, after the trial. One woman reacted allergically towards the perfume. This means a sensitization rate of 1.3 per cent, which is a maximum value, as she could, theoretically, have been sensitized before.

Animals↗
PubMed1975

double-blind"double-bind.

In a double-blind trial over a 2-week period in 34 patients with psoriases vulgaris, clobetasol propionate cream was shown to be more effective than betamethasone valerate cream. In a further 16 patients whose psoriasis had not responded to betamethasone valerate ointment, treatment with clobetasol propionate ointment was substituted. Fourteen of the 16 patients experienced a rapid improvement of their lesions.

Adolescent↗
PubMed1975

Incontinentia pigmenti achromians (Ito).

A case of incontinentia pigmenti achromians syndrome with associated abnormalities occurring in a 21-year-old woman is reported. Since birth she has had whorling macular, hypopigmented areas on the skin of the lateral, anterior, and posterior aspects of the trunk. Histopathological picture: the melanocytes in the depigmented areas are slightly reduced in number. Some of the associated abnormalities that she exhibits, such as coarse curly hair on her scalp, and pigmented spots in her left iris, have never before been described. Other of her symptoms--thick lips and myopia--have been reported earlier. The patient's mother, 15-year-old sister and 9-year-old brother showed, from birth, brown hyperpigmented maculae on the left halves of their bodies.

Abnormalities, Multiple↗
PubMed1975

[Comparison between 2 steroid dosage forms in psoriasis and eczema].

This trial was designed to evaluate the clinical effect of a new Topical steroid, the desoximetasone (test name A 41 304 from Hoechst Aktiengesellschaft). A randomized, double-blind, right-left comparative trial has been carried out in 22 patients with atopic dermatitis and on 24 patients with psoriasis. As a comparative drug, a betamethasone 17-valerate preparation, being the strongest on the market, has been used. The new compound showed a better effect on both indications, the difference being significant (p less than 0,005) on psoriasis.

Adolescent↗