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Biomedical subjects

L Hellgren

Publications and source records attributed to L Hellgren.

At least 37 records · Page 2Linked to original sources
PubMed1983

A virus-like particle associated with psoriasis.

Virus-like particles were demonstrated by electron microscopy of specimens from psoriatic plaques. Cell cultures established from plaques released particles, showing the morphological features of a retrovirus, for a prolonged period. The particles had a buoyant density of 1.17 g/cc and contained a surface protein of Mr 70,000 which bound to concanavalin A and therefore probably was of glycoprotein nature. A major internal protein of Mr 30,000 and two minor proteins of Mr 18,000 and 15,000 were detected. The composition of the proteins therefore resembled that of murine C-type retrovirus. Patients with psoriasis release virus-like particles in their urine which have a different morphology to the particles from cell cultures. A similar difference could be observed in particles from cell cultures after treatment with normal urine. Patients with psoriatic arthritis had serum immune complexes. The complexes contained distorted particles which could not be identified as virions on a morphological basis. A radio immunoassay was performed which demonstrated common antigens in the virus-like particles isolated from psoriatic urines, immune complexes and cell cultures.

Adult↗
PubMed1983

Tromantadine hydrochloride in the treatment of herpes simplex. Results of a double-blind therapeutic trial and an open prophylactic investigation.

In a randomised, double-blind trial on 20 patients with herpes simplex, tromantadine hydrochloride (TH) ointment had a significant therapeutic effect. No side effects were observed. 12 lesions were treated with the active drug and 13 with placebo. In an open study on 19 patients with recurrent herpes simplex, the prophylactic effect of the drug was good in most patients. During long-term treatment, 2 patients developed eczematous lesions. It is concluded that TH is a valuable topical agent for the treatment of herpes simplex.

Administration, Oral↗
PubMed1982

The ultrastructure of the human bulbo-urethral gland.

The first ultrastructural description of the human bulbo-urethral gland (Cowper's gland) is presented. In light microscopy the secretory cells are cuboidal or cylindrical with a clear cytoplasm and a peripherally located round, rather dense nucleus. Myoepithelial cells are demonstrated in the secretory tissue. The electron microscopy reveals numerous membrane bound secretory granules with dense cored matrix in the cytoplasm. This special composition of the secretory granules corresponds to the analogue glands in ram and bull. The secretory activities seem to be correlated to the development of the gland as a function of sexual maturity of the individual. Secretory granules are found also in surrounding capillaries, which suggests that this gland also has an endocrine function.

Adult↗
PubMed1981

Prostaglandin-like substances in Propionibacterium acnes. VI. Characterization of the lipid fraction by gas chromatography in conjunction with mass spectrometry.

The lipid fraction of P. acnes was submitted to stepwise purification followed by bioassay in order to localize the prostaglandin-like material. GC-MS analysis revealed the occurrence of substances having a part but not a total molecule in common with the prostaglandin family, suggesting that prostaglandin-like substances represent a new group of prostaglandin compounds.

Gas Chromatography-Mass Spectrometry↗
PubMed1981

Lipolytic activity of some dermatophytes. II. Isolation and characterisation of the lipase of Epidermophyton floccosum.

The physicochemical properties, stability and localisation of lipase from the anthropophilic dermatophyte Epidermophyton floccosum have been investigated. The lipase was best secreted by older cultures at an optimum pH of 6.5-7 in the temperature range 40-45 degrees C. Neither the skin-surface lipids nor the body temperature of man significantly affected the activity of the lipase.

Drug Stability↗
PubMed1981

Effect of systemic erythromycin stearate on the inflammatory lesions and skin surface fatty acids in acne vulgaris.

In a 6-week and double-blind study the efficacy of systemic administered erythromycin stearate and doxycycline was compared in 56 patients with facial acne vulgaris. With both antibiotics a statistically significant improvement was demonstrated without any difference between the two groups. No patient had to withdraw therapy due to side-effects. Another part of this investigation correlates the degree of inflammation in acne vulgaris with the fatty acid level in human skin surface lipids before and after systemic erythromycin stearate therapy. This antibiotic reduced the amount of fatty acids 25--50% after a month of medication. The reduction was correlated with a definite clinical improvement in 14 of the 17 patients.

Acne Vulgaris↗
PubMed1980

Antibodies against extractable components from Propionibacterium acnes in humans with and without acne vulgaris.

Acidic polysaccharides (AP) are released from Propionibacterium acnes I and II during growth. Similar antigens are released from two strains of P. avidum, but in a smaller amount. Furthermore, prostaglandin-like substances (PLS) have been isolated from the lipid fraction of P. acnes. The AP antigens give rise to a precipitation reaction against a large proportion of normal sera. However, significantly higher antibody titre levels towards the AP fraction were found in patients with severe acne vulgaris. No rise of antibodies was found towards PLS. These findings suggest that AP's may contribute to the inflammatory response in acne vulgaris as antigens, whereas PLS, as one of the potential mediators trigger development of the initial lesions.

Acne Vulgaris↗