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Biomedical subjects

L Heller

Publications and source records attributed to L Heller.

At least 55 records · Page 3Linked to original sources
PubMed1987

Urinary continence after stroke: association with cystometric profile and computerised tomography findings.

Repeated cystometry was performed in 17 patients after a cerebrovascular accident. Cranial computerised tomography (CT) was performed in all patients. In this series, urinary continence showed a significant correlation both with cystometric bladder tone and with the CT brain findings. The most favourable prognostic factors for urinary continence were a non-hypertonic bladder and absence of extensive brain lesions.

Adult↗
PubMed1986

Evaluation of Tinel's and Phalen's signs in diagnosis of the carpal tunnel syndrome.

In 80 upper extremities clinically suspected of carpal tunnel syndrome, electromyography (EMG) was performed and the Phalen and Tinel signs were sought. These two signs showed relatively low sensitivity (60-67%) and specificity (59-77%) despite a statistically significant association with the EMG findings. These two signs are not reliable as clinical criteria for carpal tunnel syndrome.

Adult↗
PubMed1985

Early results of a trial of the Oka-strain varicella vaccine in children with leukaemia or other malignancies in Sweden.

Nineteen children with acute lymphoblastic leukaemia or other malignancies, aged 3-13 years, with negative histories of varicella-zoster virus (VZV) and of whom 5 were still on regular maintenance chemotherapy, were vaccinated with the Oka-strain varicella vaccine. Mild systemic reactions, involving low-grade fever of a few days duration, were recorded in 4 of the vaccinees. Two of them also developed an extremely sparse rash. A mild local reaction at the vaccination site was observed in 1 child. Conversion rates for circulating VZV antibody, measured at 4-6 weeks and 4-6 months after vaccination using an indirect immunofluorescence test, were 8/12 (67%) and 5/9 (56%), respectively. Markedly lower antibody conversion rates of 5/18 (28%) and 5/14 (36%) were found by means of the enzyme-linked immunosorbent assay method. Corresponding conversion rates for cell-mediated immunity against VZV, determined using a specific lymphocyte stimulation technique, were 9/17 (52%) and 12/14 (86%), respectively.

Adolescent↗
PubMed1983

Mass vaccination programme aimed at eradicating measles, mumps, and rubella in Sweden: first experience.

General vaccination with a combined measles, mumps, and rubella vaccine was introduced in Sweden in 1982. The immunisation schedule comprises two vaccine injections, given at 18 months and 12 years of age, respectively. A controlled field study was carried out in 150 children aged 18 months using two different batches of the vaccine. Seroconversion was seen in 96% against measles, 93% against mumps, and 99% against rubella--the same rates with both vaccine lots. Nevertheless, a difference was noted between the two batches with respect to postvaccination reactions. Fever and rash were recorded mainly five to 12 days after vaccination. Moderate fever (38.5-39.4 degrees C) was observed in 22 children, high fever (greater than or equal to 39.5 degrees C) in 33, and rash in 35. Preliminary results obtained by follow up of routinely vaccinated schoolchildren aged 12 indicated considerably lower rates of fever and rash during the postvaccination period, occurring in 3-10% of cases only. These findings show that complete eradication of measles, mumps, and rubella in Sweden is entirely practicable by the mass vaccination programme and that side effects of vaccination are likely to be few and mild.

Child↗
PubMed1983

The immunizing effect and reactogenicity of two live attenuated mumps virus vaccines in Swedish schoolchildren.

An evaluation of the seroconversion and booster effects after vaccination with two different mumps vaccines, the Urabe Am 9 strain and the Jeryl Lynn strain, was carried out in schoolchildren. Four hundred and fifty-four schoolchildren aged 11 to 12 years with no previous history of mumps or mumps vaccination were enrolled for the study. The antibody responses were measured by serum neutralization (SN) and haemolysis-in-gel (HIG) tests. Of the 454 subjects, 130 were found to be initially seronegative. Two lots of different strengths of each vaccine were used to evaluate the relationships. The Urabe Am 9 vaccine lots had infectivity titres of 100 000 and 19 000 TCID50 per dose and the Jeryl Lynn vaccine titres of 59 000 and 28 000 TCID50 per dose. Only slight differences in seroconversion rates were seen between the lots. The overall seroconversion rate, measured by SN, was 94% for the Urabe Am 9 vaccine and 91% for the Jeryl Lynn vaccine, whereas the geometric mean titre for virus-neutralizing antibody in seroconverting children was 7.4 with the Urabe Am 9 vaccine and 10.7 with the Jeryl Lynn vaccine. In children who were seropositive prior to vaccination, a marked rise in antibody titre was found 8 weeks after vaccine injection indicating a booster effect. The miscellaneous post-vaccination side-effects were mild and inconsequential.

Antibodies, Viral↗
PubMed1982

Maquet osteotomy for chondromalacia patellae: avoiding the pitfalls.

The authors' modification of the classic Maquet procedure of anterior displacement of the tibial tubercle allows effective decompression of the patellofemoral joint. Strict adherence to the modified technique has prevented all major complications. Forty-four patients underwent this procedure. They were divided into a retrospective group of 20 and a prospective group of 24. Nine patients in the prospective group had the modified Maquet procedure following a failed Hauser operation. All had an excellent result due to decrease in the patellofemoral compression force. The modified Maquet procedure was also valuable in those who had an extensor lag following patellectomy (two patients), failed proximal realignment (three patients) and failed patellar shaving procedures (three patients).

Adolescent↗
PubMed1982

Variation of time-distance parameters of the stride as related to clinical gait improvement in hemiplegics.

Gait improvement was evaluated in two different ways for 20 hemiplegics during an average follow-up period of 8 weeks in early rehabilitation. One way was by weekly measuring time-distance parameters of the stride on an electrical contact system walkway. The second was a clinical evaluation of gait improvement. The parameters studied were contact time, double contact time, stride length, velocity, time symmetry and distance symmetry. The variation of each of these parameters during the follow-up period was correlated with the variation in gait evaluated clinically. This correlation showed that both evaluations agreed, supporting the usage of time-distance parameters as a tool for an objective follow-up of walking ability of hemiplegics during rehabilitation.

Aged↗
PubMed1981

Replication of poliovirus and measles virus in cultures of human lymphoblastoid and of Burkitt lymphoma cell lines.

Poliovirus type 1 replicated in 4 different human lymphoblastoid cell lines (LBL) transformed in vitro by EBV virus or isolated from cases of mononucleosis. Maximum virus titers were reached 2--4 days after inoculation. There was a decrease in percentage of viable cells in the infected cultures but a considerable fraction of cells was not destroyed by virus replication. A persistent low grade replication of virus was observed and demonstrable during 56 days after inoculation in one LBL cell line. Presumably a small fraction of cells supporting virus replication is continuously recruited from refractory cells. No virus propagation was demonstrable in 4 Burkitt lymphoma (BL) cell lines. Measles virus grew efficiently in both types of cell lines. Using indirect immunofluorescent technique poliovirus and measles virus antigen could be demonstrated in the cytoplasm of LBL cells in parallel with disappearance of F-actin containing microvilli.

Burkitt Lymphoma↗
PubMed1981

Antibodies against poliomyelitis and measles viruses in immunized and unimmunized children, Ghana 1976-78.

The serological response of children to two doses of live oral poliomyelitis vaccine (the first at age 3-8 months and the second at age 9-14 months) and to one dose of measles vaccine (at age 9-14 months) was determined in two regions of Ghana. The seroconversion rates after two doses of poliomyelitis vaccine were lower than expected-24% for poliovirus type 1, 60% for type 2, and 52% for type 3; 23% of the subjects were triple negative. A third dose of the vaccine increased the seroconversion rates to 36%, 73%, and 61% for poliovirus types 1, 2, and 3, respectively; the rate for triple negatives fell to 8%. In the course of the study it was found that there was an intensive circulation of wild polioviruses and that a high proportion of 3-8 month-old infants had maternal antibodies.The seroconversion rate following one dose of measles vaccine was about 90%, a response similar to that obtained in temperate climates. The two main conclusions drawn from the study were: (1) two doses of poliomyelitis vaccine are inadequate to provide protection against poliomyelitis in developing countries; and (2) in developing countries measles vaccine should be given as soon as possible after the age of 8 months.

Antibodies, Viral↗