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Biomedical subjects

L Hartley

Publications and source records attributed to L Hartley.

66 records · Page 4Linked to original sources
PubMed1979

Carcinoma of the oesophagus.

A survey of carcinoma of the oesophagus at Kalafong Hospital revealed a greater incidence of the disease in males, being highest in the age group 50 - 59 years, with the middle third of the oesophagus the most prevalent site and with oesophagotracheal or oesophagobronchial fistulae a common complication.

Adolescent↗
PubMed1978

Paradoxical effects in sleep and performance of two doses of chlorpromazine.

Twenty-four subjects were given placebo, 25 mg, and 75 mg of chlorpromazine on three separate occasions. Twelve subjects were treated in the morning and tested for performance during the day. Twelve other subjects received the drug treatments in the evening. Both groups had their EEG stages of sleep recorded during the subsequent night. The low dose of drug shortened the REM/non-REM cycle length in comparison to the high dose, and placebo values were intermediate. In performance tests, visual integration time was impaired by the high dose of the drug. Logical reasoning was slowed by the high dose of the drug in comparison to the low dose, with placebo values intermediate between the two.

Adult↗
PubMed1978

Chlorpromazine and serial reaction performance.

The effect of 25 mg or 75 mg of chlorpromazine on the serial reaction performance of 12 male human subjects was studied. Speed or number of correct responses was reduced by the high dose of chlorpromazine and errors of commission and omission were increased. The adverse effect of the drug upon speed appeared only at the end of the half-hour test. By contrast the adverse effect upon gaps and errors was apparent throughout the test and there was no interaction with test duration.

Administration, Oral↗
PubMed1977

Behavioural antagonism between chlorpromazine and noise in man.

The effects of 25 mg and 75 mg of chlorpromazine and of 95 dBA of white noise were studied separately and together in 12 male human subjects. Performance, analysed by signal detection theory, showed that both noise and chlorpromazine applied separately caused impairment in similar ways. Suspended judgements were reduced and negative decisions correspondingly increased at low levels of evidence. When applied together, chlorpromazine and noise cancelled out each other's adverse effects. It is concluded that chlorpromazine is a specific behavioural antagonist of the stressful effects of noise.

Arousal↗
PubMedDate not supplied

UK physicians' attitudes and practices in long-term non-invasive ventilation of Duchenne Muscular Dystrophy.

Previous studies have shown that long-term non-invasive ventilation (NIV) is not always routinely offered by all physicians in Duchenne Muscular Dystrophy (DMD), despite evidence that this treatment improves quality of life and survival. This study examined UK physicians' practices related to respiratory follow-up and DMD ventilation. A mailed questionnaire was used. Thirty-eight of the 59 (64%) UK physicians identified via the Muscular Dystrophy Campaign (MDC) responded. Eighty-one per cent of respondents felt ethically obliged to discuss NIV with families while 13% believed that NIV results in poor quality of life. Forty-seven per cent of physicians discuss in-depth the use of NIV when the patient is in respiratory failure. Eighty-four ventilated DMD patients in the respondents' practice use NIV (via Bi-Pap Nasal mask). Nearly 66% of physicians do not consider the public cost to be an impediment to offering NIV, despite significant problems with resources' allocation in their area. While the majority of UK physicians have comparable attitudes and practices regarding NIV, the questionnaire highlighted that not all specialists were aware of the existence of consensus guidelines regarding respiratory monitoring. In addition, different practices of disclosure of life-prolonging ventilation options were used by different physicians. Seventy-one per cent of physicians wished for national consensus guidelines for different DMD age groups.

Adult↗