Moles in Australian and British school children.
Explore the source record for details and available documents.
Australia↗
Biomedical subjects
L Hanson
Publications and source records attributed to L Hanson.
Identification of a channel catfish, Ictalurus punctatus (Rafinesque), leukocyte-specific leucine zipper protein.
Five clones isolated from a channel catfish cDNA library were each reactive with monoclonal antibodies (mAbs) C3-1 and 51A only. The size of the cDNA inserts from C3-1 and 51A positive clones was 2.5 Kb and identical based on sequence analysis. Monoclonal antibodies C3-1 and 51A specifically reacted with the expressed product of the 2.5 Kb cDNA clone. The complete DNA sequence indicated that the 2.5 Kb cDNA encoded an approximately 50 Kd protein molecule consisting of 445 amino acids. Sequence analysis showed that this putative protein was a potential leucine-zipper DNA binding protein. Comparison of the deduced amino acid sequence demonstrated homology (14.6 to 19.5%) throughout the sequence of the catfish protein with a group of cytoplasmic-leucine zipper containing proteins of humans; paraneoplastic cellebellar degeneration related (cdr) antigen 2 and 3 with 39.8 to 56.3% homology in the leucine-zipper motif (amino acids 52 through 175 in the catfish protein). This protein was detected in nuclear extracts. cytoplasmic membrane preparations and cytosolic extracts of neutrophils and lymphocytes when reacted with mAbs C3-1 and 51A in an ELISA. However, the intensity of the reactions was dependent upon the cell type and cellular component. The putative cdr protein was not detected with any appreciable intensity in preparations from other cell types. This finding strongly suggests that this protein is expressed in a leukocyte-specific manner and is unique among the cdr group in that it is being expressed in a site that is not immune privileged.
Amino Acid Sequence↗
Nurse-midwives' knowledge and promotion of lactational amenorrhea and other natural family-planning methods for child spacing.
The purpose of this study was to describe and assess certified nurse-midwives' (CNMs) knowledge and promotion of two modalities for child spacing, natural family-planning (NFP) and the lactational amenorrhea method (LAM). One thousand two hundred CNMs were randomly selected from a national membership list and mailed a 24-item questionnaire on NFP and LAM. Of the 514 respondents (42.8% return rate), 450 (87.5%) were currently practicing as CNMs. Respondents had an average age of 46 years, with an average of 10 years of practice. CNMs ranked NFP as the ninth most used and the eighth most effective family-planning method in their practice, with an average perceived method-effectiveness of 88% and use-effectiveness of 70%. Although most respondents felt somewhat prepared during their education program to provide NFP, only 22% would offer NFP as a family-planning option for child spacing.
Amenorrhea↗
Advice and dissent: rating the corporate governance compact.
The July-August 1991 HBR presented "A New Compact for Owners and Directors," a set of principles for reconciling differences between owners and managers. In "Advice and Dissent: Rating the Corporate Governance Compact," a panel of three experts evaluates the Compact--and takes issue with its fundamental recommendation. Clifton R. Wharton, Jr., chairman and CEO of TIAA-CREF, describes how his organization brings delinquent managers and directors to task. Harvard Business School professor Jay W. Lorsch explains why strengthening the role of outside directors will develop more effective corporate control. And Lord Hanson, chairman of Hanson PLC, reaffirms the importance of maintaining a unitary board of directors and maximizing shareholder value.
Administrative Personnel↗
Evaluation of DRI enzyme immunoassays for drugs-of-abuse screening on the Cobas Mira.
OBJECTIVE: To establish optimal performance parameters (ratios of sample and reagents, reaction time, and distinction of absorbance values between calibrators) on the Roche Cobas Mira analyzer for the evaluation of Diagnostic Reagents Inc enzyme immunoassay reagents for urine screening of amphetamines, cannabinoids, cocaine metabolite, opiates, and phencyclidine. SETTING: Laboratory in a physician's office. PRACTICE DESCRIPTION: Two laboratorians analyze a daily average of 25 urine samples for employment screening purposes. PRODUCT COMPARISON: DRI reagents were compared to Syva EMIT reagents. RESULTS: Within-run and between-run precision at the cutoff concentration for DRI reagents ranged from 1.1% to 1.6% CV and 2.2% to 5.7% CV respectively. Results (positive or negative) using DRI or Syva EMIT reagents were identical for cannabinoids, cocaine metabolite, opiates and PCP. Direct comparison for amphetamines was not possible because of different cutoff concentrations of the 2 reagents systems. CONCLUSION: DRI reagents are acceptable alternatives to EMIT reagents for the analysis of amphetamines, cannabinoids, cocaine metabolite, opiates and phencyclidine in urine on the Cobas Mira analyzer. Utilization of DRI reagents for more than 12 months demonstrated the reliability of the reagents and allowed cost comparison. ABBREVIATIONS: DRI = Diagnostic Reagents Inc; EMIT = enzyme multiplied immunoassay technique; d.a.u. = drugs of abuse; PCP = phencyclidine; GC/MS = gas chromatography/mass spectrometry.
Enzyme Multiplied Immunoassay Technique↗
A model for the future. Certified nurse-midwives replace residents and house staff in hospitals.
In one model of the future, certified nurse-midwives (CNMs) replace most obstetric residents and house staff in hospitals. This model offers numerous benefits, such as cost containment and quality outcomes. Furthermore, its application could open opportunities for educating CNMs and residents in a truly collaborative model in an educational setting and begin to balance the ratio of physicians to CNMs in the care of low-risk populations. This model was used with some success in the late 1980s to early 1990s at an inner-city Midwestern medical center. By definition, CNMs are educated in the two disciplines of nursing and midwifery and possess evidence of certification according to the requirements of the American College of Nurse Midwives (ACNM, 1978). Nurse-midwifery practice is the independent management of care of normal newborns and women, antepartally, intrapartally, postpartally, and/or gynecologically. Certified Nurse Midwifery practice occurs within a health care system that provides for medical consultation, collaborative management, and referral (ACNM, 1978). Physician and CNM roles differ. Certified nurse-midwives focus on supporting the process of normal birth, whereas physicians focus more on the management of complications. There are data that suggest that CNM outcomes are equivalent to those of physicians (American Nurses Association, 1992; Thompson, 1986; Wilson, 1989); that CNM costs are less than those of physicians (Bell & Mills, 1989; Cherry & Foster, 1982; Gravely & Littlefield, 1992; Rooks, 1986); and that the cost of educating CNMs is much less than the cost of educating physicians (Safriet, 1992). Within an environment of health care reform and cost containment, CNMs can replace residents and house staff in hospitals in the care of low-risk clients and work in consultation with physicians for the care of high-risk clients. This article compares medical education and nurse-midwifery education, reviews nurse-midwifery outcome data, and discusses the pros and cons of a practice model for the future.
Certification↗
Evaluation of online course discussions. Faculty facilitation of active student learning.
Graduate nursing faculty evaluated their initial experiences with online course discussions after making the transition from traditional use of weekly face-to-face classroom discussions to primarily computer-based interactions with students at distant sites. The online discussion data were analyzed qualitatively. The ways the faculty member communicated to facilitate active student involvement in the online discussions were coded. Six categories were identified that describe the ways the faculty member communicated to facilitate active student involvement in online discussions: assist with navigation, explain expectations, clarify faculty role, stimulate critical thinking, share expertise, and provide encouragement. Examples of each were provided to demonstrate ways faculty promoted student learning in online discussions.
Attitude of Health Personnel↗
Helpful hints in caring for patients receiving biotherapy. Rigors associated with outpatient tumor necrosis factor administration.
Explore the source record for details and available documents.
Clinical Trials as Topic↗
Recognition and classification of clinically dysplastic nevi from photographs: a study of interobserver variation.
The recognition of dysplastic nevi from photographs can aid in population surveys of nevi and in epidemiological studies of melanoma risk. The reproducibility of techniques for recognizing nevi as dysplastic or for scoring them according to the degree of dysplasia has not been measured. Using photographs of 300 nevi taken in the course of a case-control study of melanoma, we assessed the agreement among six clinicians in independently categorizing nevi as dysplastic and in grading the degree of dysplasia. On average, reviewers agreed with each other 77% of the time in classifying a nevus as dysplastic or normal. Pairwise agreement within one point on a six-point scale occurred 87% of the time on average. These results suggest that criteria for recognizing nevi as clinically dysplastic from photographs can be applied reproducibility.
Analysis of Variance↗