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Biomedical subjects

L Hamminga

Publications and source records attributed to L Hamminga.

8 recordsLinked to original sources
PubMed1997

Ranitidine does not affect psoriasis: a multicenter, double-blind, placebo-controlled study.

BACKGROUND: Data from open studies suggest that ranitidine has a beneficial effect on psoriasis and is well tolerated. OBJECTIVE: Our purpose was to determine the effectiveness of ranitidine in a 24-week, multicenter, double-blind, placebo-controlled, dose-comparing study of 201 patients with psoriasis. METHODS: Patients with moderate to severe psoriasis who had stopped systemic antipsoriatic therapy, including PUVA and UVB, for at least 10 weeks were included. After a washout period of 2 weeks, patients were randomly allocated to use either ranitidine, 150 mg twice a day; ranitidine, 300 mg twice a day; or placebo for up to 24 weeks. Assessment with the Psoriasis Area and Severity Index was performed at weeks 3, 6, 9, 12, 18, and 24 after randomization. Reduction of the Psoriasis Area and Severity Index score by 70% at the completion of the study was considered a treatment success. RESULTS: The success rates at week 24 in the 300 mg, 600 mg, and placebo groups were 11%, 5%, and 12%, respectively. No significant differences were observed between the three treatment groups at any stage of the study. CONCLUSION: This study provides strong evidence that ranitidine does not affect the skin disease in patients with psoriasis.

Adult↗
PubMed1982

Cutaneous T-cell lymphoma: clinicopathological relationships, therapy and survival in ninety-two patients.

Clinicopathological findings, methods of treatment and survival in ninety-two patients with cutaneous T-cell lymphoma (CTCL) (eighty-five mycosis fungoides and seven Sézary syndrome), seen in the Leiden University Hospital between 1974 and 1980, are reported. All patients were staged and treatment was given accordingly. Patients without signs of extracutaneous disease (74%) were treated with eigher total-skin electron-beam irradiation (E beam), topical mechlorethamine (HN2) or PUVA. Topical HN2 and E beam had an equal effect on survival. Electron-beam induced a higher number of initial complete remissions than HN2, but fewer patients relapsed while on maintenance treatment with HN2. In the patients with lymph node and/or visceral involvement, E beam followed by systemic chemotherapy--cyclophosphamide, vincristin (Oncovin) and prednisone (COP)--gave better results than topical therapy or COP alone. Survival was influenced most by the type of skin lesion, the presence or absence of lymph node and/or visceral involvement, and the ability to induce a complete remission initially.

Adult↗
PubMed1982

Functions of peripheral-blood monocytes and granulocytes in cutaneous T-cell lymphoma.

Granulocyte and monocyte functions (phagocytosis, intracellular killing, chemokinesis and chemotaxis) and the opsonic and chemotactic activity of the serum of twenty-two patients with cutaneous T-cell lymphoma were assessed. Granulocyte functions were within the normal control range in most cases. The monocyte functions showed more variation in the test results; in six out of twenty-two patients intracellular killing of Staphylococcus aureus was depressed and in four out of ten patients a disturbance in monocyte chemotaxis was found. Two patients with a decreased chemotactic response also had an impaired capacity to kill S. aureus. No correlation was found between the cell disturbance and susceptibility to infection, stage of the disease, or clinical course in these patients.

Adult↗
PubMed1981

Staging lymphography with respect to lymph node histology, treatment, and follow-up in patients with mycosis fungoides.

Extracutaneous involvement in mycosis fungoides (MF) is associated with a poor prognosis. Therefore, a pretreatment staging procedure is used to determine the extent of the disease. As part of the staging procedure lymphography was performed in 36 patients with MF. The radiographic findings and the correlation of these findings with the histopathologic changes in lymph nodes and the clinical course are described. Lymphography in MF shows a variety of abnormalities. However, these abnormalities correlate in only 61% of the patients with the extent and the clinical course of the disease. It is concluded that lymphography is not a useful clinical tool in the staging of MF.

Adult↗
PubMed1979

Sézary's syndrome: a clinical evaluation of eight patients.

Clinical and laboratory investigations of 8 patients with Sézary's syndrome are presented. Sézary cells were found in peripheral blood as well as in bone marrow and lymph nodes. The overall follow-up period was 8 years. Different therapeutic regimens were given. The best results were obtained with chlorambucil and prednisone orally, combined with topical application of nitrogen mustard. Three patients died of pneumonia and septicaemia.

Aged↗
PubMed1978

Abnormal circulating red blood cells in the painful bruising syndrome.

Red cells of 3 patients with the painful bruising syndrome showed morphological abnormalities. In the fraction not sedimenting in Ficoll/Isopaque gradient centrifugation, some of the cells had club-shaped processes, mitochondria, nuclear remnants, and vacuoles. In freeze-etch preparations, 90% of the red cells showed membrane elevations at pH 7.4 and 25% at pH 6.4, while in freeze-etch preparations of controls these values were 55 and 0 respectively. In addition, rouleaux formation was markedly enhanced in the preparations of blood of patients with the painful bruising syndrome.

Adult↗