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Biomedical subjects

L H Storlien

Publications and source records attributed to L H Storlien.

121 records · Page 7Linked to original sources
PubMed1982

Developmental study of adipose cellularity in lateral hypothalamic-lesioned Zucker obese rats.

Ten-week-old lean and obese Zucker rats were sham lesioned or received bilateral, electrolytic lesions of the lateral hypothalamus (LH). They were maintained on a wet mash diet until killing at 15 or 32 wk of age; control lean and obese rats were also killed at 6 and 10 wk. Body composition analyses were performed and adipocyte cellularity of epididymal, retroperitoneal, and subcutaneous depots were calculated. Changes in body composition of LH-lesioned rats, though similar in the two genotypes on an absolute basis, differed on a percentage basis due to the extreme adiposity of the obese rats. Retarded development of protein depots in both lesioned lean and obese rats was apparent at 15 but not 32 wk. Relative to genotypic controls, lesioned lean and obese rats had smaller adipose depots by 32 wk due to decreased adipocyte size in lean rats and reduced adipocyte number in the obese. This genotype-specific response was probably due to the chronic hyperplasia of adipocytes unique to the obese rats. This distinctive developmental pattern of the epididymal depot is discussed.

Adipose Tissue↗
PubMed1981

Oxygen consumption and locomotor activity during restricted feeding and realimentation.

Both the resting rate of O2 consumption and the heat increment in response to an intubated meal were measured in male rats following periods of food restriction and during realimentation. In one experiment, resting rates of O2 consumption were significantly reduced below control values after food consumption had been restricted and during a substantial part of an 11-day period of controlled realimentation. In a second experiment, the heat increment in response to an intubated meal was also significantly less following an interval of food restriction and during the early stages of realimentation. The reduction in O2 consumption was not related to reduced locomotor activity. These results obtained whether O2 consumption was measured in absolute amount or was referenced to an estimate of the animal's metabolically active tissue (kg body wt0.75). It is suggested that these metabolic adaptations contribute significantly to the enhanced efficiency of food utilization reported in food-restricted animals during controlled realimentation.

Animals↗
PubMed1980

Effect of lateral hypothalamic lesions on regulation of body weight and adiposity in rats.

Obese and lean Zucker rats received bilateral electrolytic lesions of the lateral hypothalamus (LH) at 10 wk of age; control obese and lean rats were sham lesioned. After lesioning the body weights of both obese and lean animals were first reduced and then maintained until being killed (32 wk) at a stable percentage of the nonlesioned control levels (74.5 and 78.3%, respectively). Carcass analysis revealed that the adipose tissue mass was significantly lowered by LH lesions in both the obese and lean animals. Percent carcass fat of lesioned lean rats was less than that of controls (15.0 vs. 23.5%) due to the presence of slightly, but not significantly, smaller and fewer adipocytes. Though absolute levels of fat were likewise lowered in obese rats, their percent carcass fat remained at control levels (52.0 vs. 53.0%) due to equivalent decreases in other body compartments. In the lesioned rats the reduced levels of adipose tissue were associated with a significant reduction in adipocyte number; adipocyte size was unchanged. It is concluded that the lateral hypothalamus of obese Zucker rats participates in the regulation of body weight in the same manner as in lean rats. The differences noted in percent carcass fat between LH lesioned lean and obese Zucker rats are apparently related to the obese animal's known propensity to sequester energy in the form of lipid.

Adipose Tissue↗
PubMed1969

Hyperphagia in rats with cuts between the ventromedial and lateral hypothalamus.

Bilateral cuts between the ventromedial and lateral hypothalamus in female rats consistently produced hyperphagia. Hyperphagia occurred slightly less reliably when one of the cuts entered the ventromedial hypothalamus and only infrequently if one entered the lateral hypothalamus. The results are consistent with other evidence that suggests that fibers originating medially stop eating by inhibiting cells in the lateral hypothalamus.

Animals↗