Search PubMed⌕ Search

Biomedical subjects

L H Sobin

Publications and source records attributed to L H Sobin.

At least 145 records · Page 8Linked to original sources
PubMed1982

The World Health Organization's Histological Classification of Lung Tumors: a comparison of the first and second editions.

Revision of the WHO Histological Classification of Lung Tumors of 1967 has resulted in the 1981 publication of the second edition. The main features of the revisions have been summarized. Squamous cell carcinoma (epidermoid carcinoma) has the same definition as in the original version, ie, the identification of keratin and/or intercellular bridges by light microscopy. Three degrees of histological differentiation have been described. Dysplasia and carcinoma in situ have been discussed. Small cell carcinoma has been divided into oat cell carcinoma, an intermediate cell type and a category for oat cell carcinomas combined with other major types. Adenocarcinoma includes the acinar, papillary and bronchiolo-alveolar forms, and the solid carcinomas with mucus formation (previously part of the large cell carcinoma group). A number of less common tumors and tumor-like lesions have been defined. None of the changes in the revision are considered to be a major departure from the original classification. This is intended in order to preserve comparability between data collected with each edition. The need for utilizing standardized nomenclature, diagnostic criteria, and tabulation formats is stressed.

Adenocarcinoma↗
PubMed1981

The international histological classification of tumours.

This article reviews the development of the WHO project on the histological classification of tumours, which has included the establishment of several collaborating centres and has involved more than 300 pathologists in over 50 countries. The project has resulted in the publication, over the last 14 years, of 25 volumes in the first series of the International Histological Classification of Tumours (IHCT), each giving a classification of tumours specific to a certain site. The classifications are based primarily on the microscopic characteristics of the tumours and are concerned with morphologically identifiable cell types and histological patterns as seen by means of light microscopy and conventional staining techniques. The article also describes the relationship between IHCT and other classification and coding systems and assesses possible future developments that may result from new approaches to diagnosis.

Humans↗
PubMed1980

Human lymph node morphology as a function of age and site.

Cervical, axillary, cubital, inguinal, popliteal, and mesenteric lymph nodes from subjects of various ages who had died a sudden death were examined histologically. Care was taken to establish by morphometry the proportional distribution in lymph node cross-sections of cortical, paracortical, and medullary areas. In addition, numbers and surface areas of cross-sectioned germinal centres were registered. Important differences related to age and anatomical site of lymph nodes were established by this survey. Germinal centre formation, particularly evident in infants and children, less so in young adults, and often absent in ageing individuals, was most impressive in lymph nodes normally exposed to antigenic stimulation (mesenteric and cervical lymph nodes). Paracortical and medullary areas exhibited a slight but gradual reduction with advancing age. Replacement of lymphatic parenchyma by fat tissue (lipomatous atrophy) was a characteristic of more peripheral lymph nodes usually subjected to little antigenic stimulation, that is, cubital, axillary, and popliteal nodes. It should be emphasised that both age-related and regional differences have to be taken into account in a meaningful functional interpretation of lymph node morphology.

Adipose Tissue↗
PubMed1980

Precancerous conditions and epithelial dysplasia in the stomach.

A distinction can be made between a precancerous condition and a precancerous lesion. The former is a clinical state associated with a significantly increased risk of cancer, whereas a precancerous lesion is a histopathological abnormality in which cancer is more likely to occur than in its apparently normal counterpart. Up to the present time atrophic gastritis, gastric ulcer, pernicious anaemia, gastric stumps, gastric polyps, and Ménétrier's disease have all been considered as precancerous conditions and lesions of the stomach. Of these, only atrophic gastritis, pernicious anaemia, gastric stumps, and certain types of gastric polyp can now be regarded as having any really significant malignant potential. The precancerous lesion common to these is epithelial dysplasia which can occur in ordinary (foveolar) gastric epithelium as well as in intestinal metaplasia. The criteria for grading dysplasia in gastric epithelium into mild, moderate, and severe grades are given, and attention is drawn to the problems of differentiating inflammatory or regenerative change from mild dysplasia and intramucosal carcinoma from severe dysplasia. The clinical and epidemiological implications of gastric dysplasia are discussed with suggestions for further research.

Anemia, Pernicious↗
PubMed1980

Incidence of prostatic carcinoma.

Prostatic carcinoma is a common cancer. It shows geographical differences in incidence which may help in the search for its etiology. It differs from lung cancer in age distribution. Recent studies on latent carcinoma show unexpected geographical trends. A number of biases must be kept in mind when studying prostatic cancer incidence and mortality figures.

Adult↗
PubMed1978

The WHO histological classification of urinary bladder tumours.

The WHO histological classification of urinary bladder tumours was formulated to promote better international communication and more reliable statistical comparisons. The axes of classification concern histological type, grade of anaplasia and growth pattern.

Humans↗
PubMed1978

The morphology of cirrhosis. Recommendations on definition, nomenclature, and classification by a working group sponsored by the World Health Organization.

This memorandum provides guidelines on the definition, nomenclature, and classification of cirrhosis, chronic hepatitis, and hepatic fibrosis. These are considered according to morphological characteristics and aetiology. It is hoped that this system will serve as a standard for diagnostic, research, and epidemiological purposes. The relationship of cirrhosis to liver cell carcinoma is briefly discussed and the possible morphological markers of an increased risk of malignancy are defined.

Chronic Disease↗
PubMed1977

Standardization and the histopathology of tumours.

Standardization of tumor classifications is a prerequisite in facilitating international communication in cancer research. Standardized classifications are not meant to replace, or compete with, conceptual classifications. The World Health Organization's efforts in this field give consideration to definitions of tumour types, terminology, formats of categorization, and codes.

Neoplasms↗