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Biomedical subjects

L H Kimmel

Publications and source records attributed to L H Kimmel.

9 recordsLinked to original sources
PubMed2001

Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases.

Janus kinases comprise carboxyterminal kinase, pseudokinase, SH2-like, and N-terminal FERM domains. We identified three patient-derived mutations in the FERM domain of Jak3 and investigated the functional consequences of these mutations. These mutations inhibited receptor binding and also abrogated kinase activity, suggesting interactions between the FERM and kinase domains. In fact, the domains were found to physically associate, and coexpression of the FERM domain enhanced activity of the isolated kinase domain. Conversely, staurosporine, which alters kinase domain structure, disrupted receptor binding, even though the catalytic activity of Jak3 is dispensable for receptor binding. Thus, the Jak FERM domain appears to have two critical functions: receptor interaction and maintenance of kinase integrity.

Adenosine Triphosphate↗
PubMed1998

Just got your pin?

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Career Mobility↗
PubMed1994

Identification of a binding site in the disintegrin domain of fertilin required for sperm-egg fusion.

Fertilization and certain later stages in mammalian embryonic development require fusion between membranes of individual cells. The mechanism of eukaryotic cell-cell fusion is unknown, and no surface molecules required for this process have been unequivocally identified. The role of the sperm surface protein fertilin in sperm-egg fusion was tested by using peptide analogues of a potential integrin binding site in the fertilin beta subunit. Peptide analogues that include a TDE sequence from the disintegrin region of fertilin beta are able to bind to the egg plasma membrane and strongly inhibit sperm-egg fusion. These results show that the disintegrin domain of fertilin beta binds to the egg plasma membrane and that this binding is required for membrane fusion.

ADAM Proteins↗
PubMed1994

Educating the paraprofessional staff on the psychiatric unit. A neglected topic.

Upon deinstitutionalization, a mentally ill person's awareness of the stigma attached to his or her illness can negatively influence any effort to become a productive member of society. Support systems are vital in that they facilitate such efforts. The family is perhaps the most important support system because it provides emotional support, which is crucial because it promotes a sense of self-esteem and decreases depression, anxiety, sickness, and mortality. An awareness of stigma on the part of the family could undermine its role as a support system for a relative with mental illness.

Adaptation, Psychological↗
PubMed1993

Molecular cloning of the human and monkey sperm surface protein PH-20.

The guinea pig sperm surface protein PH-20 has an essential function in sperm adhesion to the zona pellucida of guinea pig eggs. Fully effective contraception has been achieved by immunizing either male or female guinea pigs with purified guinea pig PH-20. Here we report the isolation of human and cynomolgus monkey PH-20 cDNAs as a key step toward testing the function of primate PH-20 and the contraceptive efficacy of PH-20 immunization in primates. The deduced amino acid sequence of human PH-20 has 509 residues and is 59% identical with guinea pig PH-20, suggesting they may have a conserved function and immunogenicity. Southern blots show that there is a single PH-20 gene in the human genome and Northern blots of human testis poly(A)+ RNA show a 2.4-kb message. Northern blots of tissues other than testis are negative for PH-20, indicating that human PH-20 is testis-specific.

Algorithms↗
PubMed1991

The concept of elastic boundaries applied to group therapy with veterans over 60 years old.

This article develops the concept of elastic boundaries within a supportive model of group therapy for elderly patients with chronic medical and psychiatric illnesses in a Veterans Affairs Medical Center outpatient service. The rationale for deviating from established group boundaries in therapist and patient behavior is discussed in relation to group goals and Veterans Affairs culture. Systems issues in an external decision-making environment is explained as a negative influence. Vignettes are liberally shared to demonstrate how elastic boundaries as a concept developed within the group.

Age Factors↗
PubMed1990

Therapeutic groups.

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Combined Modality Therapy↗
PubMed1989

Guiding the way: acting as a preceptor for graduate students.

This article has conceptualized and discussed clinical preceptorship of graduate students in psychiatric nursing, an area poorly represented in the literature. While grounded firmly in the nursing process, it is flexible to accommodate other frameworks as the student participates in various learning activities to meet her course objectives. Many issues have been addressed to guide the preceptor in helping the student approach her new role with realistic expectations, increased confidence, and visions of a future filled with promise.

Education, Nursing, Graduate↗