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Biomedical subjects

L H Brown

Publications and source records attributed to L H Brown.

At least 37 records · Page 2Linked to original sources
PubMed1994

Adverse lighting condition effects on the assessment of capillary refill.

In 1989, Champion et al recommended revising the Trauma Score to exclude capillary refill because it is "difficult to assess at night. . . ." However, a literature search produced no studies evaluating the effect of lighting conditions on the assessment of capillary refill. This study was undertaken to determine if any such effect exists. Three hundred nine participants at an emergency medical services (EMS) seminar were asked to assess each others' capillary refill in both light and dark environments. The participants were nurses, emergency medical technicians (EMTs), and paramedics who had been instructed in the assessment of capillary refill. In daylight conditions (partly cloudy day, lux meter = 15 to 16), capillary refill was reported as normal in 94.2% of the participants, delayed in 1.9% of the participants, and undetected in 3.9% of the participants. In dark conditions (moonlight or street lamp, lux meter = 4 to 6), capillary refill was reported as normal in 31.7% of the participants, delayed in 1.6% of the participants, and undetected in 66.7% of the participants. chi 2 analysis demonstrated a statistically significant difference between capillary refill assessment in light versus dark environments (P < .001).

Adolescent↗
PubMed1990

Study of the teratogenic potential of FD & C Yellow No. 5 when given by gavage to rats.

FD & C Yellow No. 5 (tartrazine) was given to Osborne-Mendel rats by gavage at dose levels of 0, 60, 100, 200, 400, 600 or 1000 mg/kg body weight/day on days 0-19 of gestation. No maternal or developmental toxicity was observed when the rats were killed on day 20. The mean daily food consumption for the entire period of gestation was significantly greater in the females given 1000 mg/kg body weight/day than in the controls, but maternal body-weight gain was not affected. No dose-related effects were observed in implantations, foetal viability or external foetal development. Foetal skeletal and visceral development was similar among foetuses from all groups. At the doses given, FD & C Yellow No. 5 was neither toxic nor teratogenic.

Abnormalities, Drug-Induced↗
PubMed1989

Study of the teratogenic potential of FD & C Red No. 40 when given by gavage to rats.

Osborne-Mendel rats were intubated with FD & C Red No. 40 at dose levels of 0, 30, 75, 150, 300, 600, or 1000 mg/kg body weight/day on days 0-19 of gestation. No developmental toxicity was observed when the animals were killed on day 20 of gestation. No dose-related changes were seen in maternal daily observations, food consumption, body-weight gain or implantations, or in foetal viability, body weight, body length, sex distribution or external variations. Skeletal and soft-tissue development appeared similar in foetuses of all groups. The isolated increases that occurred in the number of male foetuses, number of females with two or more resorptions, number of litters with three or more sternebral variations and incidence of 14th rib bud are considered random occurrences and were not related to dosage.

Administration, Oral↗
PubMed1989

Study of the teratogenic potential of FD&C Red No. 40 when given in drinking water.

FD&C Red No. 40 in the drinking water at a level of 0, 0.2, 0.4, or 0.7% was available ad libitum to female Osborne-Mendel rats throughout gestation. The treated females consumed 273.6, 545.7, and 939.3 mg FD&C Red No. 40 per kg body weight per day, respectively, for the three dose levels. The animals were sacrificed on gestation day 20. No fetal terata were seen. There were no dose-related changes in maternal findings, number of fetuses, fetal viability, or external or visceral variations. Skeletal development appeared similar to that of the control animals with the exception of the incidence of fetuses with reduced ossification of the hyoid, which was increased significantly at the 0.7% dose level. A dose-related increase occurred in the number of litters containing fetuses with at least two skeletal variations, but the numbers of litters with fetuses with at least one and at least three variations were not different from control values.

Abnormalities, Drug-Induced↗
PubMed1989

Reestablishing patency in an occluded central venous access device.

Nurses in a full range of settings from acute to home care are increasingly exposed to the use and maintenance of central VADs. Although the advantages of central VADs are well recognized, the incidence and potential for complications associated with these devices should not be minimized. The major complication of catheter occlusion has the potential of inducing significant morbidity and mortality. The purpose of the following care plan is to familiarize the nurse with the information needed to restore catheter patency efficiently, safely, and effectively, thereby reducing the potential complications and enhancing the quality of patient care.

Catheters, Indwelling↗
PubMed1987

Study of the teratogenic potential of gum arabic.

Gum arabic in the diet at 0, 1, 2, 4, 7.5 or 15% was available ad lib. to male and female Osborne-Mendel rats during premating and mating and throughout gestation. During gestation, the treated females consumed from 683 mg gum/kg body weight/day in the 1% group to 10,647 mg gum/kg/day in the 15% group. The animals were killed on gestation day 20. There were no dose-related changes in maternal findings, number of foetuses, foetal viability or external, visceral or skeletal variations. No terata were seen.

Abnormalities, Drug-Induced↗
PubMed1987

Scatter dose for wedged fields.

The behaviour of scatter dose in 4 and 8 MV wedged x-ray beams has been studied by calculating scatter-to-primary dose ratios (SPR) and comparing these with SPR for non-wedged beams. On the central axis the SPR for wedged and non-wedged beams differ only by a few per cent, a difference which increases slightly with wedge angle and field size. In other points within the field the differences are larger but generally less than 3% of the total dose on the central axis at the same depth. The product rule for points that do not lie in a principal plane is valid within the same limits as for non-wedged beams.

Cobalt Radioisotopes↗
PubMed1983

Rapid identification of enterococci.

Enterococci were identified in 4 h with bile esculin agar and the Autobac system (General Diagnostics, Warner-Lambert Co., Morris Plains, N.J.), which was used to incubate and monitor salt broth for growth. Of 86 group D streptococci tested, 41 enterococci grew in salt broth and were bile esculin positive within 4 h; none of 45 group D nonenterococcal streptococci exhibited growth in the salt broth, and only 38 of them were bile esculin positive within 4 h.

Agar↗
PubMed1967

The amino acid sequence of Pseudomonas fluorescens azurin.

The amino acid sequence of Pseudomonas fluorescens azurin has been determined. The protein consists of a single peptide chain of 128 residues. There is one intra-chain disulphide bridge. The sequence was determined by isolation of the soluble tryptic peptides, and by exhaustive examination of the products of chymotryptic and peptic digestion. The sequence has been confirmed by the purification and analysis of the seven fragments obtained by cyanogen bromide treatment of the protein.

Amino Acid Sequence↗
PubMed1967

Rhinophyma.

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Adult↗