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Biomedical subjects

L Guize

Publications and source records attributed to L Guize.

195 records · Page 11Linked to original sources
PubMedDate not supplied

[Evaluation of nonpharmacologic invasive treatment in cardiology: the example of implantable automatic defibrillators].

Substantial therapeutic advances have been achieved in cardiology in the last fifteen years. They are due to the progress of cardiovascular pharmacology and interventional cardiology. Many devices are now competing with drugs. In France, the evaluation procedures of these two types of treatment are highly different. The benefit/risk ratio is not evaluated sufficiently before the marketing authorization of the devices. The procedures leading to reimbursement by Social Security are completely different for the drugs and the devices, and harmonization of these procedures is essential. It could allow the avoidance of paradoxical situations such as that of the automatic implantable defibrillator whose efficacy is now validated by controlled studies; but payment for which is not reimbursed by Social Security. The consequence is a serious dearth of this item, the implantation ratio per million residents in France being lower than that of all neighbouring countries.

Defibrillators, Implantable↗
PubMedDate not supplied

Contribution of the high amplitude electrocardiography to the detection of ventricular late potentials in several cardiovascular diseases.

The criteria for detection of ventricular late potentials (VLP) by high amplitude electrocardiography (ECG) in the frequency domain were evaluated in 75 patients with cardiovascular diseases, mostly men (85%), with a mean age of 57 years, distributed by disease type into three subgroups: (1) with a history of myocardial infarction (MI)--53 cases; (2) with syncopes, episodes of prolonged ventricular arrhythmias--18 cases; (3) with unobstructive, primary cardiomyopathies--4 cases. Complete clinical examination, standard ECG, continuous 24 hr Holter ECG, high amplitude ECG (Corazonix system) for detection of VLP by analyses in the time domain (TD) and in the frequency one (FD) were performed in all the cases. The VLP incidence was evidently high in all the cases. By association of the analyses in TD and FD, the accuracy of VLP detection increased by 17.3% in the whole group (from 64% to 81.3%). The incidence of severe ventricular arrhythmias (class 4-5 Lown, i.e., doubled and/or trebled ventricular extrasystoles, salvos of unsustained ventricular tachycardia) was evidently higher in the patients with VLP (88% compared with 77% in the absence of VLP), thus demonstrating the presence, in most of the patients studied, of an arrhythmogenic mechanism by ventricular reentry.

Adolescent↗
PubMedDate not supplied

[Distribution and correlations of serum uric-acid in two French adult populations: 13,885 men and 6,861 women (author's transl)].

Distributions and correlations of serum uric acid (SUA) were studied in 13,885 men and 6,861 women who were between the ages of 20 and 90. In men and women the distribution of SUA is unimodal. The average SUA value is 6,28 mg/100 ml SD: 1,19) in men and 5,05 mg/100 ml (SD: 1,10) in women, 27% of the men and 4% of the women have a SUA level above 7 mg/100 ml. In men and in women correlations of SUA with an obesity index is strong (r = 0,272; r = 0,311). In men partial correlations between SUA and age, blood pressure, cholesterolemia, glycemia and hemoglobinemia diminish when obesity index is fixed. In women these correlations are stronger and do not vary when obesity index is fixed. In men and women the correlation between SUA and creatininemia is strong and do not vary when obesity index is fixed.

Adult↗