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Biomedical subjects

L Guillevin

Publications and source records attributed to L Guillevin.

At least 397 records · Page 22Linked to original sources
PubMed1983

[Etiology and precipitating factors of necrotizing angiitis with respiratory manifestations. 5 case reports].

Five cases of periarteritis nodosa or Churg and Strauss angeitis are reported. They all had one feature in common, their onset after desensitivity procedures, an injection of gammaglobulin or vaccination. These factors were found either at the onset or before a relapse of the disease. None of the patients had HBS antigen, which supports the hypothesis of a multiple antigenic etiology of periarteritis nodosa, some of which may cause respiratory symptoms, especially asthmatic attacks. The authors emphasise the importance of prohibiting desensitivity procedures and vaccinations in patients with severe asthma.

Adult↗
PubMed1983

Treatment of progressive systemic sclerosis with plasma exchange. Seven cases.

Seven patients, 4 women and 3 men afflicted with severe progressive systemic sclerosis (PSS) were treated with Plasma Exchange after failure of different other treatment. All patients presented Raynaud phenomenon and arthritis, 6 patients presented extensive skin lesions, 5 of them digestive manifestations, 3 pulmonary fibrosis. In one case PSS was associated with polymyositis, one patient presented bilateral recurrent cornea ulcerations, (Sjögren Syndrome++) and one patient numerous skin ulcerations. In 5 patients adjuvant corticosteroid therapy was given during the course of PE. In 3 patients PE must be stopped after one or two sessions because of insufficient venous access. Among the 4 other patients 8 to 20 PE were performed: the patient with cornea ulcerations became blind during the treatment, skin ulcerations and severe Raynaud phenomenon did not improved in two other patients. Benefit of PE was noted in only one patient with regressive myositis, and improvement of articular and cutaneous symptoms. Therefore, PE are not useful in most patients afflicted with PSS, they are difficult to realize in numerous patients and did not improve clinical symptoms in most cases.

Adolescent↗
PubMed1982

[Value of plasma exchange in necrotizing angeitis. 11 cases].

Plasma exchanges proved useful in a series of 11 patients with necrotizing angeitis resistant to conventional treatment (corticosteroids alone in 6 cases and combined with cyclophosphamide in 5 cases). Among the 9 patients alive after 18 months' follow-up, 5 were in remission without treatment. The only disturbing complication of plasma exchanges was hepatitis B in 3 of the 4 survivors who received frozen fresh plasma as substitute. It is suggested that these immuno-compromized patients should receive diluted albumin instead of fresh frozen plasma.

Adolescent↗
PubMed1982

[Thrombophlebitis of the superior sagittal sinus in patient with systemic lupus erythematosus (author's transl)].

The case reported here is the first observation of thrombophlebitis of the superior sagittal and left transverse sinuses in a patient with systemic lupus erythematosus. Thrombophlebitis occurred thirty-six years after onset of SLE. The patient had neither nephrotic syndrome nor serum anti-coagulants. Various hypotheses concerning pathogenesis are suggested. The opportunity for heparin therapy is discussed.

Adolescent↗
PubMed1982

[Proliferative glomerulopathy in pneumococcal septicemia in a patient with lupus (author's transl)].

Acute glomerulopathy due to pneumococcal infection occurred in a patient with chronic discoid lupus. The onset of renal involvement in this context suggested that cutaneous lupus may have developed into systemic lupus erythematosus. Renal biopsy established the correct diagnosis. The physiopathology of glomerular involvement in lupus and infections is discussed. Attention is drawn to the significance of complement activation, either by the classical or the alternative pathways according to the etiology.

Adult↗
PubMed1982

[The renin-angiotensin system in hypertensive patients with scleroderma and polyarteritis nodosa (author's transl)].

The renin-angiotensin system was studied in 14 normotensive and hypertensive patients with scleroderma and polyarteritis nodosa (PAN). The variations in blood pressure, plasma renin activity (PRA) and serum aldosterone were compared after the Captopril test. Mean arterial pressure fell 15,7 +/- 2,6 p. 100 (p less than 0,01) in hypertensive patients, but no change was observed in normotensive subjects. PRA and serum aldosterone did not change significantly in hypertensives with scleroderma. Large variations in blood pressure, PRA and serum aldosterone were observed in 2 out of 3 patients with PAN, the third one presenting a fall in blood pressure without significant changes in PRA or serum aldosterone. These results suggest that other mechanisms are responsible for hypertension in these patients and that the Captopril acted on other factors than the renin-angiotensin system.

Blood Pressure↗
PubMed1982

[Sclerodermic cardiomyopathy : prospective study employing phonocardiography and echocardiography. Value of diastolic parameters of ventricular function (author's transl)].

A prospective study in 30 patients with systemic sclerosis included phonocardiographic (PCG) recordings in all cases and an echocardiogram (ECHO) in 18 patients. A specific diagnosis of myocardial fibrosis was established in 2 cases, based on anatomical criteria, and was suspected in 5 patients from combined clinical, electrical, and radiological findings. Ventricular diameters, the slope of mitral valve closure, and systolic parameters of ventricular function (haemodynamic quotient, left ventricle ejection fraction, and mean rate of circumferential shortening) were rarely abnormal, and did not correlate with possible myocardial fibrosis. Diastolic pick-up (PCG) was abnormal in 30 p. cent of the cases but this is not specific to myocardial fibrosis. Total myocardial relaxation interval, as measured by PCG, was significantly increased to 146 +/- 23 ms (mean +/- one standard deviation) in relation to a control group (p less than 0.001). A relaxation interval (measured by PCG and/or ECHO) superior to 150 ms is suggestive of myocardial fibrosis. The rate of thinning of the left ventricular posterior wall was diminished in the 14 cases in which it was measured. These results are in favour of a myocardial relaxation disorder during scleroderma.

Adult↗