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Biomedical subjects

L Gozariu

Publications and source records attributed to L Gozariu.

65 records · Page 4Linked to original sources
PubMedDate not supplied

Effect of magnesium ion upon the calcitonin content of rat thyroid.

Thyroid calcitonin level was assayed in male rats after administration of magnesium gluconolactate. The resulting acute hypermagnesemia caused a significant decrease in calcitonin. However, calcemia showed unimportant changes, which suggests that the inhibitory action of magnesium is exerted directly on calcitonin secretion and is not affected by the calcium ion.

Animals↗
PubMedDate not supplied

Adrenal function in early and metastatic breast cancer: dexamethasone suppression of plasma cortisol.

Plasma cortisol, 17-hydroxyprogesterone (17-OH-P), progesterone, FSH, LH and prolactin were determined by RIA, in 14 cancer patients without metastases aged between 40 and 74 years (6 cases of breast cancer: T123, N01, M0 and 8 with other forms of cancer). The cancer patients were investigated: (A) under basal conditions, (B) after three days' adrenal suppression by dexamethasone, 3 mg/day and (C) immediately after local radiation therapy (4500 rads). The basal mean hormonal values in these patients showed increased cortisol, decrease 17-OH-P and normal values of progesterone, FSH, LH and prolactin. Plasma cortisol was significantly reduced by adrenal suppression with a percentage reduction of 19.44 without differences between breast cancer patients and patients with other forms of cancer; adrenal suppression induced an increase of 17-OH-P only in male cancer patients. The only significant hormonal changes after local radiation therapy were increased plasma 17-OH-P values in both female and male cancer patients. A second group investigated in the present study consisted of 11 patients (6 castrated and 5 postmenopausal women) with metastatic breast cancer and presented increased plasma cortisol values, decreased 17-OH-P values, and a great scatter in the estrone values, some of them being very high.

Adrenal Glands↗
PubMedDate not supplied

45Ca uptake in tooth germs: effects of parathormone, calcitonin and propranolol.

Tooth germs harvested from 6-day-old rats were incubated in a 45Ca-containing medium for 6 hours. The addition of PTH consistently stimulated the increase in 45Ca uptake, while calcitonin significantly reduced both the PTH-stimulated incorporation and the spontaneous one. Dibutyrul CAMP (3.5 mM) had no effects. Propranolol significantly inhibited the spontaneous and stimulated 45Ca uptake. Results obtained support the concept that the two hormones have a clear influence on calcium entering the tooth germs in full calcification process probably by early membrane effect.

Animals↗
PubMedDate not supplied

Calcitonin secretion in hyperthyroidism.

The level of circulatory calcitonin was determined by the RIA method in 45 hyperthyroid patients in evolution, before and after calcium stimulation or after pentagastrin injection. The basal calcitonin secretion was increased in only 7 of the 45 patients studied, exceeding 500 pg/ml. After a slow calcium loading the mean of calcitonin increased, but with variable individual values. The rapid calcium loading was not followed by significant increases after 30 minutes. After pentagastrin a secretory peak of over 1,800 pg/ml was obtained in 4/5 cases. Results point out the state of the calcitonin-secreting system in hyperthyroidism and its possible role in the skeleton protection in these patients.

Adolescent↗
PubMedDate not supplied

Effect of thyroid hormones on osteolysis "in vitro".

The effect of triiodothyronine and thyroxine no the stimulation of the release of 45Ca was followed up in rat calvaria incubated "in vitro" and compared with the effect produced by parathormone. Both triiodothyronine and thyroxine stimulated osteolysis. The response was dependent on dose. Triiodothyronine may intensify the effect of parathormone if added to the incubation medium, whereas thyroxine does not exert the same effect. The results obtained demonstrated a well defined osteolytic effect of both thyroid hormones.

Animals↗
PubMedDate not supplied

Calcitonin secretion in chronic renal patients treated with hemodialysis.

Calcitonin levels were studied in 18 patients with chronic renal insufficiency periodically hemodialysed, comparatively with 9 only drug-treated uremic patients. Calcitonin was radioimmunologically assayed before and after hemodialysis and repeated 5 months later in some of the patients. Serum calcitonin was increased in most of the studied patients, especially in the dialysed ones and with a creatinine clearance below 10 ml/min. Calcitonin concentration was all the more increased as the dialytic treatment lasted longer. Considering the increasing role of calcitonin as osteoprotector, these findings might be of interest in the treatment of renal osteopathy.

Adult↗
PubMedDate not supplied

Skeletal calcium retention in hyperthyroidism and in vitro calcitonin inactivation.

Studies on patients with severe hyperthyroidism revealed an increased skeletal avidity for calcium, expressed in terms of net retention, after a three-hour i.v. load of 10mg Ca/kg body weight. For the same hyperthyroid subjects the calcitonin inactivating potency of the sera was tested in vitro. The results were expressed as restant hypocalcemic potency of the calcitonin after incubation with the serum fractions. In hyperthyroid subjects two fractions in dilutions of 1:10 reduced the hypocalcemic activity of calcitonin by 75%. In normals this activity appeared only in one fraction. All these results suggest a prompt calcitonin release during calcium infusion which is however less efficient, probably because of the increased amount of calcitonin inactivating factor present in sera. The serum inactivating factor generally contributes to the short-time activity of calcitonin both in normals and in some clinical states with bone calcium imbalance.

Bone and Bones↗