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Biomedical subjects

L Gothefors

Publications and source records attributed to L Gothefors.

61 records · Page 4Linked to original sources
PubMed1975

Breast feeding and biological properties of faecal E. coli strains.

Human milk may contribute to protection against gram-negative infection by promoting intraluminal agglutination or killing of bacteria or by preventing bacterial attachment to epithelial surfaces. This paper explores the effect of human milk on the sensitivity of faecal E. coli to serum bactericidal activity and agglutination specificity, factors which have been regarded as related to virulence. Faecal E. coli isolated from breast-fed infants differed from those from formula-fed infants in two respects: They were more sensitive to the bactericidal effect of human serum and more often spontaneously agglutinating. E. coli strains isolated from sources outside the gastro-intestinal tract, that is the prepuce and female peri-urethral region, were in breast-fed babies less sensitive than faecal strains. The findings are compatible with the hypothesis that a breast-milk factor favours the proliferation of mutant strains. The observed effects of breast-milk might be associated with decreased bacterial virulence, and be one of the ways in which breast-feeding protects against infection.

Agglutination Tests↗
PubMed1975

Lactoperoxidase activity in human milk and in saliva of newborn infants.

Human milk and saliva from newborn infants were analyzed for their content of lactoperoxidase and thiocyanate. The activity of lactoperoxidase in infant saliva was variable but generally higher than that found in calf saliva. In contrast, the activity in human colostrum was low ( approximately 5%) compared with that found in cow's milk. The enzyme was resistant to gastric juice. Thiocyanate was demonstrated in infant saliva in concentrations about one-third of that in adult saliva. The amounts of lactoperoxidase and thiocyanate in infant saliva are quite sufficient to inhibit bacterial growth in in vitro systems. The importance of this system in vivo has not yet been demonstrated. The availability of this system to both newborn calves and humans (in calves provided largely by colostrum and in human babies by saliva) might be indirect evidence of its importance.

Adult↗
PubMed1975

Transmission of Lactobacillus jensenii and Lactobacillus acidophilus from mother to child at time of delivery.

The presence of Lactobacillus jensenii and Lactobacillus acidophilus has been studied in specimens from the rectum and vagina of the mother, from the mouth of the infant at the time of delivery, and from the mouth and rectum of infants six days of age. L. jensenii could be differentiated from other species of lactobacilli by the following combination of characteristics: production of only D-lactate, hydrolysis of arginine, and fermentation of cellobiose, galactose, and ribose, but not of lactose. L. jensenii and L. acidophilus were common inhabitants of the vagina. In spite of a contamination of the infant's mouth by L. jensenii and L. acidophilus during delivery, neither of these organisms became established in the mouth of the newborn infants.

Adult↗
PubMed1975

The nitroblue tetrazolium (NBT) test and white blood cell count in acute throat infections.

The clinical value of the NBT test and of leucocyte counts in the aetiological differentiation of acute throat infections was investigated. In our hands a frequency of less than 13% NBT positive neutrophils is considered as normal and a test value above 19% as "positive", i.e. indicating a bacterial infection. More than 19% or more than 1 800 NBT positive neutrophils per mm-3 blood were found in 10 of 18 patients with an infection caused by beta-haemolytic streptococci, in 1 of 2 patients with a Mycoplasma pneumoniae infection and in 1 patient with both a streptococcal and mycoplasmal infection, but in none of 19 patients with a viral infection. Since 8 of 18 patients with streptococcal throat infection had normal NBT test results, the NBT test apparently is of limited value in the early recognition of these infections. A high NBT test value would however support the diagnosis. The white blood cell and neutrophil counts were of little value in the differentiation between streptococcal and viral throat infection.

Acute Disease↗