Search PubMed⌕ Search

Biomedical subjects

L Gorini

Publications and source records attributed to L Gorini.

43 records · Page 3Linked to original sources
PubMed1965

Amino acid changes provoked by streptomycin in a polypeptide synthesized in vitro.

The misincorporation of isoleucine provoked by streptomycin in a polyuridylate-directed incorporating system from Escherichia coli has been examined by a double-labeling technique with phenylalanine-(3)H and isoleucine-(14)C. The polypeptides synthesized are associated with 70S ribosomes and contain only phenylalanine in the absence of streptomycin, and both phenylalanine and isoleucine in the presence of the antibiotic. Results of acid hydrolysis and subsequent chymotryptic digestion of the polypeptides indicate that the misincorporated amino acid is inserted by peptide bonding with phenylalanine and is randomly distributed along the chain.

Carbon Isotopes↗
PubMedDate not supplied

[Agranulocytosis caused by dipyrone. Case reports].

Two cases of dipyrone-induced agranulocytosis are described. In the first one, the disease was due to a single administration, in the second one, to prolonged therapy. The possible pathogenic mechanism is discussed, which can be immunologic and/or toxic. The effectiveness of some of the drugs and general supportive measures applied is discussed. Health education of the patient, in conjunction with careful attention by the physician, may play an important role in the prevention of this pathological condition.

Agranulocytosis↗