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Biomedical subjects

L Gordon

Publications and source records attributed to L Gordon.

At least 253 records · Page 14Linked to original sources
PubMed1978

Histological changes in skeletal muscle after temporary independent occlusion of arterial and venous supply.

In both replantation and transplantation, circulation is restored to ischemic muscle by vascular anastomoses. As a result, the length of time that skeletal muscle will endure ischemia is important to know clinically. Using microsurgical techniques, we shut off the blood supply to the quadriceps femoris muscle in adult Wistar rats--by occluding the artery, the vein, or both for varying time intervals. The muscle was maintained in the animal for 48 hours, and then examined histologically. Our results indicate that the period of warm ischemia should be limited to about one hour, because a longer period of arterial ischemia produces severe histological changes in muscle. The limiting factor seems to be the arterial, rather than the venous supply. The possibility of muscle regeneration after such ischemic insults was not investigated.

Animals↗
PubMed1977

The use of microvascular free groin flaps for the closure of difficult lower extremity wounds.

Proficiency with techniques of microvascular anastamoses allows the successful transfer of free composite grafts from distant sources. We have used the free groin flap in the reconstruction of defects of the lower extremity not amenable to standard methods of closure. A series of representative cases has been presented in this article to illustrate our approach and technique.

Accidents, Traffic↗
PubMed1977

Free osteocutaneous flap from a rib to the tibia.

A large bony defect of the tibia, covered with thin unstable scar, was repaired successfully with a free osteocutaneous flap composed of 10 cm of the ninth rib with a 9 X 6 cm area of overlying muscle and skin. Microvascular anatomoses were done between the intercostal vessels in the transplant and the anterior tibial vessels in the recipient area.

Adult↗
PubMed1977

Patient education and intrauterine contraception: a study of two package inserts.

In July 1975 the Food and Drug Administration proposed a patient information package insert for all women considering use of an intrauterine device. In the same year we also prepared a brochure to be given to women considering use of a specific intrauterine contraceptive, the PROGESTASERT system. To compare these information sources for the patient, we surveyed by mail 253 women who are or had been PROGESTASERT system users. Each woman received either the FDA or our own prepared version. Comprehension of the two inserts was generally comparable, but readers of our insert found its informational content more complete. The survey findings affirmed the desirability of providing the patient with an educational brochure to be read prior to IUD insertion.

Attitude↗
PubMed1977

Models and techniques for microsurgery research.

Microsurgery is used today to salvage severed parts and to reconstruct previous damage. Much remains to be learned in this field and laboratory research will direct future developments. Laboratory experience prior to clinical use is mandatory and takes several months of conscientious application. Various rat models are useful. Rat hind leg replantation and muscle autotransplantation provide experience in microdissection and vascular anastomoses with unequivocal end points. Finally, clinical cases have to be well chosen and meticulously planned.

Amputation, Traumatic↗
PubMed1975

Comparative pharmacologic effects of pilocarpine administered to normal subjects by eyedrops or by ocular therapeutic systems.

Normal volunteers used 1, 2, and 4% pilocarpine eyedrops, three times daily, or ocular therapeutic systems placed in the conjunctival cul-de-sac to control intraocular pressure. The systems continuously release 20 and 40 mug/hour of pilocarpine for one week. Although the amount of drug delivered to the eye from the ocular therapeutic system was one fifth that obtained from the eyedrops, the decrease of intraocular pressure was comparable. The ocular therapeutic systems produced small, constant effects on visual acuity, refractive error, and miosis that did not cause visual handicaps or require correction. The effects of eyedrops on these visual factors were large and varied and produced marked visual handicaps that were not correctable with spectacles. Despite its comparable hypotensive effect in normal subjects, continuous delivery of pilocarpine by means of an ocular therapeutic system elicits less severe side effects than pilocarpine eyedrops.

Adult↗
PubMed1975

The politics of birth control, 1920-1940: the impact of professionals.

Before the 1920s, a birth control movement arose in the United States out of socialist, feminist, and other radical groups concerned with women's rights and sexual freedom. After 1920 the birth control movement became gradually transformed into a respectable, nonradical reform cause, the recipient of large grants from big business, with women's rights secondary to an overriding concern with medical health and population control. This transformation was achieved through the professionalization of the birth control movement-that is, its takeover by professional experts, almost all male, in place of the radical amateur women, fighting for their own interests, who initiated it. The article examines two groups of professionals who were particularly influential in this transformation: doctors and academic eugenists. The former made birth control a medical issue, held back the development of popular sex education, and stifled a previously developing feminist approach to women's birth control needs. The later contributed racism to the birth control movement, helping to transform it into a population control movement with racist and anti-feminist overtones. Both groups, while they made contributions to the technology of contraception, simultaneously held back the spread of birth control by transforming the campaign for it from a popular, participatory cause to a professional staff lobbying operation.

Attitude↗