This is a prospective study of prenatal substance use. Women were interviewed during their fourth and seventh months of pregnancy, at delivery, and at 8, 18, and 36 months postpartum. At birth, there were 763 liveborn, singleton offspring in the sample. At each phase, the offspring were examined and measured for growth. Data are presented on the relationship between tobacco and marijuana use and the size of the offspring at birth, 8, 18, and 36 months of age. At birth, there was a significant inverse relationship between tobacco use and weight, length, and head circumference. At 8 months of age, only length continued to be associated with prenatal tobacco exposure. By 18 months of age, there was no relationship between prenatal tobacco exposure and size of the offspring. Prenatal marijuana exposure was only associated with decreased length at birth. Neither tobacco nor marijuana use predicted gestational age or morphological abnormalities.

Child, Preschool↗

PubMedDate not supplied

Effect of prenatal marijuana exposure on the cognitive development of offspring at age three.

Marijuana is the most commonly used illicit substance among pregnant women. Although there has been substantial concern about the effects of substance use during pregnancy, few studies have assessed the effects of prenatal exposure to marijuana and even fewer have provided longitudinal data on the developmental outcome of offspring. This is a report from a longitudinal study of substance use during pregnancy. The women in the cohort were of lower socioeconomic status, most were single, half were white and half were African-American. Women were interviewed at the fourth and seventh prenatal months, and women and children were assessed at delivery, 8, 18, and 36 months. Pediatric assessment included physical and cognitive development. At each study phase, mothers were interviewed about life style, living situation, current substance use, sociodemographic, and psychological status. Findings are reported on 655 women and children who were assessed at the third year. There were significant negative effects of prenatal marijuana exposure on the performance of 3-year-old children on the Stanford-Binet Intelligence Scale. The effects were associated with exposure during the first and second trimesters of pregnancy. Among the offspring of white women, these effects were moderated by the child's attendance at preschool/day-care at age three.

Adolescent↗

PubMedDate not supplied

Prenatal alcohol, marijuana, and tobacco use: infant mental and motor development.

These data are from a longitudinal study of prenatal alcohol and marijuana use in a low income sample. Half of the women were black and half were white. Women who used alcohol and/or marijuana during their pregnancies were light to moderate users; most decreased or discontinued their use after the first trimester. At the first follow-up phase, which occurred at a median age of 9 months, the children were functioning above average on the Bayley Scales of Infant Development (BSID). Prenatal alcohol and tobacco use did not predict BSID mental or motor scores at this phase. Third trimester marijuana use was associated with decreased BSID mental scores. Age at assessment was the most important predictor at this phase. The second follow-up occurred at a median age of 19 months when the group means for the BSID were lower. Prenatal alcohol and marijuana use did not predict outcome at this phase. Prenatal and current cigarette use were associated with decreased BSID mental scores. Demographic and environmental variables were important predictors at this phase.

Adolescent↗

PubMedDate not supplied

The effects of prenatal cocaine use on neonatal neurobehavioral status.

The effect of prenatal cocaine use on neonatal behavior was examined, using the Brazelton Neonatal Behavioral Assessment Scale (BNBAS), in a prospective study of women attending a prenatal clinic. Women were interviewed at the end of each trimester. Term infants were assessed with the BNBAS at day 2 (N = 165) (mean = 35.6 h) and at day 3 (N = 108) (mean = 60.1 h). Women averaged 25 years of age with 12 years of education; 48% were African-American and 20% were married. Women who used cocaine were more likely to use tobacco, alcohol, and marijuana. Regression analyses, with the Lester et al. (22) clusters as outcomes, were used to control for covariates of cocaine use such as other substance use and sociodemographic characteristics. On day 2, first, second, and third trimester cocaine/crack use were significantly related to poorer autonomic stability, second and third trimester use were related to poorer motor maturity and tone, and first and second trimester use were associated with an increased number of abnormal reflexes. These relationships were not present on day 3. These results may be transient expressions of the effect of prenatal cocaine exposure on central nervous system maturation.

Adult↗

PubMedDate not supplied

A nursing student + dementia patient = lessons learned.

Explore the source record for details and available documents.

Adaptation, Psychological↗

PubMedDate not supplied

Effects of prenatal marijuana exposure on child behavior problems at age 10.

This is a prospective study of the effects of prenatal marijuana exposure on child behavior problems at age 10. The sample consisted of low-income women attending a prenatal clinic. Half of the women were African-American and half were Caucasian. The majority of the women decreased their use of marijuana during pregnancy. The assessments of child behavior problems included the Child Behavior Checklist (CBCL), Teacher's Report Form (TRF), and the Swanson, Noland, and Pelham (SNAP) checklist. Multiple and logistic regressions were employed to analyze the relations between marijuana use and behavior problems of the children, while controlling for the effects of other extraneous variables. Prenatal marijuana use was significantly related to increased hyperactivity, impulsivity, and inattention symptoms as measured by the SNAP, increased delinquency as measured by the CBCL, and increased delinquency and externalizing problems as measured by the TRF. The pathway between prenatal marijuana exposure and delinquency was mediated by the effects of marijuana exposure on inattention symptoms. These findings indicate that prenatal marijuana exposure has an effect on child behavior problems at age 10.

Adult↗

PubMedDate not supplied

Prenatal substance exposure: effects on attention and impulsivity of 6-year-olds.

Attention and impulsivity of prenatally substance-exposed 6 year olds were assessed as part of a longitudinal study. Most of the women were light to moderate users of alcohol and marijuana who decreased their use after the first trimester of pregnancy. Tobacco was used by a majority of women and did not change during pregnancy. The women, recruited from a prenatal clinic, were of lower socio-economic status, and over half were African American. Attention and impulsivity were assessed using a Continuous Performance Task. Second and third trimester tobacco exposure and first trimester cocaine use predicted increased omission errors. Second trimester marijuana use predicted more commission errors and fewer omission errors. There were no significant effects of prenatal alcohol exposure. Lower Stanford-Binet Intelligence Scale composite scores, male gender, and an adult male in the household also predicted more errors of commission. Lower SBIS composite scores, younger child age, maternal work/ school status, and higher maternal hostility scores predicted more omission errors. These findings indicate that prenatal substance use has an effect on attentional processes.

Adult↗

PubMedDate not supplied

Telemedicine and information technology at the Veterans Administration Palo Alto Health Care System: serving patient care.

Explore the source record for details and available documents.

California↗